| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tomivosertib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tomivosertib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.104792 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0787714 |
| CDH13 | cadherin 13 | 0.0699778 |
| VEGFA | vascular endothelial growth factor A | 0.05386 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0536074 |
| GOLGB1 | golgin B1 | 0.052973 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0491756 |
| VIM | vimentin | 0.0478163 |
| RPS6 | ribosomal protein S6 | 0.0460765 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0459127 |
| ENO1 | enolase 1, (alpha) | 0.0427219 |
| RPS8 | ribosomal protein S8 | 0.0415458 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0413304 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0409519 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0395224 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0356736 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0354192 |
| INHBA | inhibin, beta A | 0.0326944 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0326073 |
| VCAN | versican | 0.0323328 |
| EGFR | epidermal growth factor receptor | 0.0316122 |
| IL6 | interleukin 6 | 0.0299177 |
| RPL37A | ribosomal protein L37a | 0.0295786 |
| HDAC9 | histone deacetylase 9 | 0.0294216 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.029206 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0290013 |
| SQSTM1 | sequestosome 1 | 0.028181 |
| RPS12 | ribosomal protein S12 | 0.0277074 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0264517 |
| RACK1 | receptor for activated C kinase 1 | 0.0253363 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0253114 |
| HLA-A | major histocompatibility complex, class I, A | 0.0252797 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0250874 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0250557 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0249217 |
| VMP1 | vacuole membrane protein 1 | 0.0246792 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0241645 |
| B2M | beta-2-microglobulin | 0.0236729 |
| ASPH | aspartate beta-hydroxylase | 0.0235967 |
| BRD2 | bromodomain containing 2 | 0.0235545 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0234353 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0228789 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0216407 |
| CD44 | CD44 molecule (Indian blood group) | 0.0213542 |
| SP100 | SP100 nuclear antigen | 0.0211313 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0210539 |
| MTDH | metadherin | 0.0210205 |
| POTEF | POTE ankyrin domain family, member F | 0.0202649 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0197962 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0196058 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0194439 |
| ATXN1 | ataxin 1 | 0.0189656 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.018879 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0186354 |
| RPS2 | ribosomal protein S2 | 0.0181436 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0181307 |
| RPS3 | ribosomal protein S3 | 0.0181265 |
| DSTN | destrin (actin depolymerizing factor) | 0.0180814 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0180804 |
| RND3 | Rho family GTPase 3 | 0.0178763 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0177755 |
| CADM1 | cell adhesion molecule 1 | 0.016554 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0165524 |
| NAV1 | neuron navigator 1 | 0.0164995 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0162039 |
| PRRC2C | proline-rich coiled-coil 2C | 0.016088 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0160184 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0160142 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0159253 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0158252 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0156414 |
| ATF4 | activating transcription factor 4 | 0.0156307 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0155963 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0154333 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0154235 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.015368 |
| ANXA1 | annexin A1 | 0.0153286 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0153079 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0152349 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0151276 |
| MYO10 | myosin X | 0.0151254 |
| NLRP1 | NLR family, pyrin domain containing 1 | 0.0151254 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0147477 |
| RPS17 | ribosomal protein S17 | 0.014682 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0144525 |
| STC2 | stanniocalcin 2 | 0.0144237 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0142462 |
| RPL9 | ribosomal protein L9 | 0.0142227 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0141829 |
| SON | SON DNA binding protein | 0.0140714 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0139737 |
| FOXP1 | forkhead box P1 | 0.0139667 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0137808 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.013754 |
| EFNA5 | ephrin-A5 | 0.0137014 |
| CUX1 | cut-like homeobox 1 | 0.0136999 |
| UBXN4 | UBX domain protein 4 | 0.0136798 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0136002 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0134427 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0132448 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.33051 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.193733 |
| COL1A1 | collagen, type I, alpha 1 | -0.130403 |
| COL6A3 | collagen, type VI, alpha 3 | -0.12994 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0546351 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0522586 |
| LOX | lysyl oxidase | -0.0507544 |
| ATP13A3 | ATPase type 13A3 | -0.0456126 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0376874 |
| SPAG9 | sperm associated antigen 9 | -0.0373515 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0373169 |
| AHNAK | AHNAK nucleoprotein | -0.0370467 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0368646 |
| ANXA2 | annexin A2 | -0.0362314 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0331563 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0310212 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0304711 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0299279 |
| POSTN | periostin, osteoblast specific factor | -0.0299051 |
| MT1X | metallothionein 1X | -0.0298074 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0296782 |
| PTMA | prothymosin, alpha | -0.028504 |
| USP3 | ubiquitin specific peptidase 3 | -0.0282689 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0260642 |
| HMGA2 | high mobility group AT-hook 2 | -0.0246889 |
| FLNA | filamin A, alpha | -0.0237419 |
| LOXL2 | lysyl oxidase-like 2 | -0.0234828 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0234306 |
| RBM39 | RNA binding motif protein 39 | -0.0233984 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.023173 |
| SMAD3 | SMAD family member 3 | -0.0228648 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0227837 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0226493 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.02171 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0216663 |
| TFG | TRK-fused gene | -0.021289 |
| COL1A2 | collagen, type I, alpha 2 | -0.0210404 |
| CALR | calreticulin | -0.0210257 |
| FBN1 | fibrillin 1 | -0.0209192 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0207911 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0204861 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0202998 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0201446 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0198834 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.019619 |
| TMSB10 | thymosin beta 10 | -0.0194778 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0194333 |
| PLEC | plectin | -0.019383 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0193512 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0193117 |
| ZNF292 | zinc finger protein 292 | -0.0189713 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0188901 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0187499 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0184541 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0182021 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.018188 |
| RHEB | Ras homolog enriched in brain | -0.0181759 |
| APP | amyloid beta (A4) precursor protein | -0.017911 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0178869 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.01786 |
| FSTL1 | follistatin-like 1 | -0.0175776 |
| RASA2 | RAS p21 protein activator 2 | -0.0174793 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0171658 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0167159 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0164104 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0160647 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0157605 |
| CANX | calnexin | -0.0154935 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0152069 |
| PGK1 | phosphoglycerate kinase 1 | -0.0151039 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0150628 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0150626 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | -0.0150136 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.014939 |
| COL4A1 | collagen, type IV, alpha 1 | -0.014924 |
| WDR45B | WD repeat domain 45B | -0.0149193 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0143102 |
| CALM3 | calmodulin 3 (phosphorylase kinase, delta) | -0.0140777 |
| AFAP1 | actin filament associated protein 1 | -0.0139299 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0138403 |
| SDC4 | syndecan 4 | -0.0138315 |
| HMGB2 | high mobility group box 2 | -0.0138064 |
| OGA | O-GlcNAcase | -0.0137759 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0136852 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0136759 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.013528 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0133998 |
| TSC22D2 | TSC22 domain family, member 2 | -0.013297 |
| PXDN | peroxidasin | -0.0132647 |
| QKI | QKI, KH domain containing, RNA binding | -0.0131858 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | -0.0131253 |
| COL3A1 | collagen, type III, alpha 1 | -0.0131132 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0130456 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0129244 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0129117 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0129077 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.0127109 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0124181 |
| GOLT1B | golgi transport 1B | -0.0123859 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | -0.0122836 |
