| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tomivosertib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tomivosertib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.325206 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.102594 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0879745 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0747244 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0718613 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0716981 |
| MT2A | metallothionein 2A | 0.0707759 |
| DSPP | dentin sialophosphoprotein | 0.0702556 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0659658 |
| SVIL | supervillin | 0.0657761 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0612804 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0589455 |
| DST | dystonin | 0.0556757 |
| C3 | complement component 3 | 0.0545534 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.054135 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0473648 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.045562 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0448979 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0435622 |
| RPS6 | ribosomal protein S6 | 0.0423503 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.03901 |
| QKI | QKI, KH domain containing, RNA binding | 0.0382795 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0382091 |
| RPS12 | ribosomal protein S12 | 0.0380193 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0376021 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0372451 |
| TLE4 | transducin-like enhancer of split 4 | 0.0370977 |
| VMP1 | vacuole membrane protein 1 | 0.0364326 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.036361 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0350817 |
| INTS6 | integrator complex subunit 6 | 0.0342833 |
| CLIC4 | chloride intracellular channel 4 | 0.0337409 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0323315 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0321994 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0312316 |
| FKTN | fukutin | 0.0307269 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0302569 |
| TOP1 | topoisomerase (DNA) I | 0.0300856 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0299767 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0293116 |
| BCL2L1 | BCL2-like 1 | 0.0291398 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0291306 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.029032 |
| PLIN2 | perilipin 2 | 0.029017 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0284822 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0283401 |
| DTNA | dystrobrevin, alpha | 0.0280463 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0277891 |
| DIAPH1 | diaphanous-related formin 1 | 0.0274338 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0272534 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0272252 |
| DSTN | destrin (actin depolymerizing factor) | 0.0270415 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0267647 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0263594 |
| BRD2 | bromodomain containing 2 | 0.02624 |
| ZFP36 | ZFP36 ring finger protein | 0.0258852 |
| FERMT2 | fermitin family member 2 | 0.0257306 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0255457 |
| FAM107B | family with sequence similarity 107, member B | 0.0249743 |
| H1-0 | H1.0 linker histone | 0.0249125 |
| CPE | carboxypeptidase E | 0.0248958 |
| RPS8 | ribosomal protein S8 | 0.0242439 |
| PHF3 | PHD finger protein 3 | 0.0241464 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.0238208 |
| RPL26 | ribosomal protein L26 | 0.0236544 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0234767 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0234519 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0233578 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0233126 |
| MT1G | metallothionein 1G | 0.0231356 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0231053 |
| POTEF | POTE ankyrin domain family, member F | 0.0230827 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.023082 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0227032 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0226297 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0222918 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.022088 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0219207 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0218892 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | 0.0216834 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0216371 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.021594 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.021503 |
| MCU | mitochondrial calcium uniporter | 0.0213084 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0212968 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0212927 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0212176 |
| KIF21A | kinesin family member 21A | 0.020786 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0206411 |
| EXOC6B | exocyst complex component 6B | 0.0206214 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0204808 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0203271 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.019944 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.019825 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0197736 |
| AHR | aryl hydrocarbon receptor | 0.0196977 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0195063 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0194944 |
| NCKAP1 | NCK-associated protein 1 | 0.0192 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0190496 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.352385 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.163129 |
| CP | ceruloplasmin (ferroxidase) | -0.108097 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.102185 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0910845 |
| APOA2 | apolipoprotein A-II | -0.0900374 |
| FNDC3B | fibronectin type III domain containing 3B | -0.089602 |
| GPC3 | glypican 3 | -0.0888811 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0850736 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.082853 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0699111 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0683325 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.065232 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0561398 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0558786 |
| RPLP1 | ribosomal protein, large, P1 | -0.051534 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0509431 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0508699 |
| FN1 | fibronectin 1 | -0.0503293 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0501743 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0500629 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0472395 |
| NDRG1 | N-myc downstream regulated 1 | -0.0461245 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0452176 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | -0.0451246 |
| RPS24 | ribosomal protein S24 | -0.0449735 |
| RPL34 | ribosomal protein L34 | -0.0444096 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0435872 |
| OSMR | oncostatin M receptor | -0.0434966 |
| RBM39 | RNA binding motif protein 39 | -0.0424757 |
| RPL35A | ribosomal protein L35a | -0.0412165 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.041078 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0399101 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0394208 |
| PEG3 | paternally expressed 3 | -0.0388858 |
| EHBP1 | EH domain binding protein 1 | -0.0377578 |
| GDF15 | growth differentiation factor 15 | -0.0375942 |
| MSI2 | musashi RNA-binding protein 2 | -0.0374164 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.037163 |
| GNAS | GNAS complex locus | -0.0361483 |
| TMSB10 | thymosin beta 10 | -0.0351703 |
| ENO1 | enolase 1, (alpha) | -0.0348258 |
| FERMT1 | fermitin family member 1 | -0.0347111 |
| NPR2 | natriuretic peptide receptor 2 | -0.034543 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0340886 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0340485 |
| PGK1 | phosphoglycerate kinase 1 | -0.0333194 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0330498 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0330385 |
| IER3 | immediate early response 3 | -0.0329246 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0319744 |
| A2M | alpha-2-macroglobulin | -0.0316876 |
| RRBP1 | ribosome binding protein 1 | -0.0304956 |
| RNASET2 | ribonuclease T2 | -0.0304525 |
| ATP10A | ATPase, class V, type 10A | -0.0303966 |
| ZFHX3 | zinc finger homeobox 3 | -0.030334 |
| WDR45B | WD repeat domain 45B | -0.0296532 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.029322 |
| RPL37 | ribosomal protein L37 | -0.0292589 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0283619 |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | -0.0282334 |
| RPL38 | ribosomal protein L38 | -0.0281117 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0276851 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0275031 |
| TMEM123 | transmembrane protein 123 | -0.0274524 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0272407 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0271091 |
| TMEM51 | transmembrane protein 51 | -0.0270063 |
| CTSB | cathepsin B | -0.0267411 |
| MALT1 | MALT1 paracaspase | -0.0267377 |
| GK | glycerol kinase | -0.0264208 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0263822 |
| ARFGEF3 | ARFGEF family member 3 | -0.0263722 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0261978 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0261685 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0261465 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0255165 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0254512 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0252141 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | -0.0248687 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0248583 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0246057 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0245169 |
| RPL11 | ribosomal protein L11 | -0.0241027 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0238372 |
| ITGA1 | integrin, alpha 1 | -0.0237806 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0237437 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0235281 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0234848 |
| RPL28 | ribosomal protein L28 | -0.0232225 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0228726 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0228014 |
| CALR | calreticulin | -0.0226731 |
| APOA1 | apolipoprotein A-I | -0.0223718 |
| NGLY1 | N-glycanase 1 | -0.0221743 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0217242 |
| HMGA1 | high mobility group AT-hook 1 | -0.0216714 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0216585 |
| PERP | PERP, TP53 apoptosis effector | -0.0215755 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0215065 |
