| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tomivosertib perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tomivosertib_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.166357 |
| LMO7 | LIM domain 7 | 0.163224 |
| MYOF | myoferlin | 0.0980501 |
| B2M | beta-2-microglobulin | 0.095805 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0942991 |
| TMC5 | transmembrane channel-like 5 | 0.0881366 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0860536 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0807663 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.06999 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.06786 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0676291 |
| EZR | ezrin | 0.063417 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0630305 |
| DSPP | dentin sialophosphoprotein | 0.0625298 |
| SEPTIN9 | septin 9 | 0.0588263 |
| TJP1 | tight junction protein 1 | 0.0557384 |
| GDA | guanine deaminase | 0.054919 |
| POTEF | POTE ankyrin domain family, member F | 0.054818 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0528641 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.052424 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0509567 |
| LIMA1 | LIM domain and actin binding 1 | 0.0501472 |
| PLSCR1 | phospholipid scramblase 1 | 0.0493338 |
| RPL23 | ribosomal protein L23 | 0.0476234 |
| MYO1E | myosin IE | 0.0475485 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0473151 |
| RPS19 | ribosomal protein S19 | 0.0461906 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0459962 |
| AREG | amphiregulin | 0.0458934 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0458496 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0455887 |
| RPS6 | ribosomal protein S6 | 0.0448582 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.043706 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0422987 |
| DSTN | destrin (actin depolymerizing factor) | 0.0421132 |
| VMP1 | vacuole membrane protein 1 | 0.0418433 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0417773 |
| ASPH | aspartate beta-hydroxylase | 0.0412986 |
| RPLP1 | ribosomal protein, large, P1 | 0.0403907 |
| KLF6 | Kruppel-like factor 6 | 0.0402501 |
| SP100 | SP100 nuclear antigen | 0.0401811 |
| SMAD3 | SMAD family member 3 | 0.0396374 |
| ANXA2 | annexin A2 | 0.0390803 |
| MCU | mitochondrial calcium uniporter | 0.0387273 |
| LIPH | lipase, member H | 0.0385715 |
| LAMA4 | laminin, alpha 4 | 0.0385593 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0383975 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0379376 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0372625 |
| FTL | ferritin, light polypeptide | 0.0365356 |
| RPS8 | ribosomal protein S8 | 0.035595 |
| RPS12 | ribosomal protein S12 | 0.0351396 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0342791 |
| CLDN4 | claudin 4 | 0.0339256 |
| RPS2 | ribosomal protein S2 | 0.0329526 |
| SNX9 | sorting nexin 9 | 0.0328904 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0327926 |
| RBM47 | RNA binding motif protein 47 | 0.0327539 |
| LCN2 | lipocalin 2 | 0.0326367 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0326089 |
| TXNRD1 | thioredoxin reductase 1 | 0.0322179 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0319207 |
| ATP11A | ATPase, class VI, type 11A | 0.0318407 |
| C6ORF132 | chromosome 6 open reading frame 132 | 0.0310667 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0307242 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.0303598 |
| PRSS3 | protease, serine, 3 | 0.030043 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | 0.0293116 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0288277 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0288179 |
| STK24 | serine/threonine kinase 24 | 0.0286572 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | 0.0285044 |
| VCL | vinculin | 0.0284135 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.028374 |
| SIK3 | SIK family kinase 3 | 0.0281507 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0281486 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0281478 |
| RASEF | RAS and EF-hand domain containing | 0.0278205 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0277424 |
| GOLGB1 | golgin B1 | 0.0277066 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0276327 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.027454 |
| COBL | cordon-bleu WH2 repeat protein | 0.0271842 |
| ANXA11 | annexin A11 | 0.0268244 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0268107 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0265466 |
| BPTF | bromodomain PHD finger transcription factor | 0.0264638 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0264154 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0262149 |
| TMEM45B | transmembrane protein 45B | 0.0253792 |
| PDLIM5 | PDZ and LIM domain 5 | 0.025341 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.025274 |
| CAPN8 | calpain 8 | 0.0250565 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0249656 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.024462 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0242087 |
| RPS17 | ribosomal protein S17 | 0.0241358 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0240718 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0240609 |
| HLA-A | major histocompatibility complex, class I, A | 0.024014 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.250141 |
| FGFR2 | fibroblast growth factor receptor 2 | -0.135901 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.118673 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0903372 |
| NDRG1 | N-myc downstream regulated 1 | -0.0680629 |
| TMEM123 | transmembrane protein 123 | -0.0639385 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0638916 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0593046 |
| PGK1 | phosphoglycerate kinase 1 | -0.0590459 |
| FAT1 | FAT atypical cadherin 1 | -0.0587397 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0547423 |
| WDR45B | WD repeat domain 45B | -0.0518202 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0510222 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0508602 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0496372 |
| AUTS2 | autism susceptibility candidate 2 | -0.0481535 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0476518 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0473984 |
| PTMA | prothymosin, alpha | -0.0458959 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0458671 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0457837 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0443176 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0438323 |
| EHBP1 | EH domain binding protein 1 | -0.0427338 |
| RBM39 | RNA binding motif protein 39 | -0.0418748 |
| VEGFA | vascular endothelial growth factor A | -0.0406344 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0402203 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.040017 |
| FLNB | filamin B, beta | -0.0392909 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0381288 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | -0.0381059 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0372307 |
| KRT7 | keratin 7, type II | -0.036539 |
| ITGB4 | integrin, beta 4 | -0.0360577 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0356081 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.035186 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0343629 |
| PTK2 | protein tyrosine kinase 2 | -0.0339074 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0338935 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0338323 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0337456 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0335573 |
| KRT8 | keratin 8, type II | -0.0334748 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0333279 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0325913 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0325499 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0322131 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0321753 |
| ARHGAP6 | Rho GTPase activating protein 6 | -0.0321619 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | -0.0313807 |
| ANLN | anillin, actin binding protein | -0.0302311 |
| XYLT1 | xylosyltransferase I | -0.0298832 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0297462 |
| FAM13A | family with sequence similarity 13, member A | -0.0296624 |
| TPD52 | tumor protein D52 | -0.029457 |
| CCNY | cyclin Y | -0.0291996 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0291494 |
| KLHL29 | kelch-like family member 29 | -0.0287076 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0279878 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0279115 |
| PRKCA | protein kinase C, alpha | -0.0278976 |
| RNF43 | ring finger protein 43 | -0.0278248 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0276183 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0273887 |
| CDK6 | cyclin-dependent kinase 6 | -0.0273853 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0270435 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0270017 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.025963 |
| TFRC | transferrin receptor | -0.0258618 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0258067 |
| COG5 | component of oligomeric golgi complex 5 | -0.0255606 |
| CCND1 | cyclin D1 | -0.025501 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0254673 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0254506 |
| TNIK | TRAF2 and NCK interacting kinase | -0.0253426 |
| CANX | calnexin | -0.0252504 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.0249614 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0249205 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.0248183 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0247697 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0246817 |
| EHF | ets homologous factor | -0.0245381 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0245177 |
| AXIN2 | axin 2 | -0.0243923 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.024391 |
| NFIA | nuclear factor I/A | -0.024379 |
| USP34 | ubiquitin specific peptidase 34 | -0.0243559 |
| NEK6 | NIMA-related kinase 6 | -0.0242529 |
| XPO1 | exportin 1 | -0.0239917 |
| TBCD | tubulin folding cofactor D | -0.0239774 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0239652 |
| H1-0 | H1.0 linker histone | -0.0237611 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0234151 |
| AHNAK | AHNAK nucleoprotein | -0.0233833 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0231904 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0231787 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0226229 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.022514 |
| ZNRF3 | zinc and ring finger 3 | -0.0224088 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0222806 |
