Tomivosertib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tomivosertib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tomivosertib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.223005
RPS6 ribosomal protein S6 0.112911
RPS8 ribosomal protein S8 0.0784098
RPS12 ribosomal protein S12 0.0758999
TPT1 tumor protein, translationally-controlled 1 0.0576576
FTL ferritin, light polypeptide 0.0545177
RPL37A ribosomal protein L37a 0.0534628
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0531849
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0481955
B2M beta-2-microglobulin 0.0450946
MT2A metallothionein 2A 0.0428259
LOC102724023 ES1 protein homolog, mitochondrial 0.0408556
RPL9 ribosomal protein L9 0.0379018
RPS3 ribosomal protein S3 0.0370527
VEGFA vascular endothelial growth factor A 0.0353711
POTEF POTE ankyrin domain family, member F 0.0347019
RPS19 ribosomal protein S19 0.0346253
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.031145
SYNE2 spectrin repeat containing, nuclear envelope 2 0.030296
TFF1 trefoil factor 1 0.029974
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.029539
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.029402
KTN1 kinectin 1 (kinesin receptor) 0.0291815
RPS17 ribosomal protein S17 0.0266032
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0265171
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.025525
RPL31 ribosomal protein L31 0.0249685
RPS2 ribosomal protein S2 0.0242808
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0242632
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0230772
ISG15 ISG15 ubiquitin-like modifier 0.0230384
RPS26 ribosomal protein S26 0.0223941
EXT1 exostosin glycosyltransferase 1 0.022322
ENO2 enolase 2 (gamma, neuronal) 0.0223092
RPS27 ribosomal protein S27 0.0220048
ALCAM activated leukocyte cell adhesion molecule 0.0217772
DSTN destrin (actin depolymerizing factor) 0.0217055
RPL35A ribosomal protein L35a 0.0214964
SIK3 SIK family kinase 3 0.0213382
EGFR epidermal growth factor receptor 0.0210722
TPM4 tropomyosin 4 0.0207261
MUC13 mucin 13, cell surface associated 0.0207156
IFI27 interferon, alpha-inducible protein 27 0.0207118
SOX4 SRY (sex determining region Y)-box 4 0.0206149
APLP2 amyloid beta (A4) precursor-like protein 2 0.0199575
RPL36 ribosomal protein L36 0.0199543
RPL37 ribosomal protein L37 0.0199529
TUBA1B tubulin, alpha 1b 0.0199094
SVIL supervillin 0.0198641
RPL26 ribosomal protein L26 0.0197711
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0191416
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0190976
TMSB10 thymosin beta 10 0.01909
MBNL1 muscleblind-like splicing regulator 1 0.0188257
ENO1 enolase 1, (alpha) 0.0188125
EEF1G eukaryotic translation elongation factor 1 gamma 0.018802
EZR ezrin 0.0182686
RPS27A ribosomal protein S27a 0.0177085
MARCHF3 membrane associated ring-CH-type finger 3 0.0175878
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0174145
NUCB2 nucleobindin 2 0.0171894
RPL23 ribosomal protein L23 0.0169401
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0169202
ANXA1 annexin A1 0.0169112
RPS13 ribosomal protein S13 0.0167748
RPS14 ribosomal protein S14 0.0166533
JUN jun proto-oncogene 0.0163906
RIGI RNA sensor RIG-I 0.0163164
VCAN versican 0.0162152
RPLP1 ribosomal protein, large, P1 0.0161602
LMNA lamin A/C 0.0158388
HLA-A major histocompatibility complex, class I, A 0.0156274
CRY1 cryptochrome circadian clock 1 0.0155922
ACTG1 actin gamma 1 0.0155775
BRD2 bromodomain containing 2 0.0153855
ZFP36 ZFP36 ring finger protein 0.0153132
TXNIP thioredoxin interacting protein 0.0152962
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0152604
CXCL8 chemokine (C-X-C motif) ligand 8 0.0151927
AFF1 AF4/FMR2 family, member 1 0.0151863
GPBP1 GC-rich promoter binding protein 1 0.0150712
GOLGB1 golgin B1 0.0149206
HDGF hepatoma-derived growth factor 0.0148905
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0148805
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.0148173
CSTB cystatin B (stefin B) 0.0147764
SQSTM1 sequestosome 1 0.0147318
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0146565
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0146345
ZFP36L1 ZFP36 ring finger protein-like 1 0.0146344
PRDX2 peroxiredoxin 2 0.0144244
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0142831
TPI1 triosephosphate isomerase 1 0.0142382
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0141372
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0140349
RPL18 ribosomal protein L18 0.0139552
FBXO11 F-box protein 11 0.0138885
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0138421
IFIH1 interferon induced with helicase C domain 1 0.0138378
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.013827

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.15309
CEMIP cell migration inducing protein, hyaluronan binding -0.139389
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.133443
RNF43 ring finger protein 43 -0.0888688
ANXA2 annexin A2 -0.0844234
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0838907
FAT1 FAT atypical cadherin 1 -0.0822597
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0767054
AHNAK AHNAK nucleoprotein -0.0700269
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0679961
NALF1 NALCN channel auxiliary factor 1 -0.0642449
PIGR polymeric immunoglobulin receptor -0.0617124
TNS4 tensin 4 -0.0616091
ZFAND3 zinc finger, AN1-type domain 3 -0.0591582
KRT8 keratin 8, type II -0.0589437
GPHN gephyrin -0.0574529
NFIA nuclear factor I/A -0.0531379
RBM39 RNA binding motif protein 39 -0.0526686
ACTN4 actinin, alpha 4 -0.0525925
MED13L mediator complex subunit 13-like -0.0517232
CADPS Ca++-dependent secretion activator -0.0511632
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0508891
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0491803
ITGA6 integrin, alpha 6 -0.0483054
ARHGAP32 Rho GTPase activating protein 32 -0.048009
NCOR1 nuclear receptor corepressor 1 -0.047919
PRSS3 protease, serine, 3 -0.0469538
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0463794
ONECUT3 one cut homeobox 3 -0.0450927
OGA O-GlcNAcase -0.0448294
H1-0 H1.0 linker histone -0.0446134
KDM3A lysine (K)-specific demethylase 3A -0.0428854
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0427344
FLNB filamin B, beta -0.042123
SMYD3 SET and MYND domain containing 3 -0.0421046
MON2 MON2 homolog (S. cerevisiae) -0.0419679
HDLBP high density lipoprotein binding protein -0.0404602
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.040128
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0399848
ETNK1 ethanolamine kinase 1 -0.0394918
CANX calnexin -0.0393417
GMDS GDP-mannose 4,6-dehydratase -0.0388478
ANTXR2 anthrax toxin receptor 2 -0.0384084
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0379551
PKP2 plakophilin 2 -0.0376593
ANKRD17 ankyrin repeat domain 17 -0.0367784
SHROOM3 shroom family member 3 -0.0366563
RAB10 RAB10, member RAS oncogene family -0.0360125
KDM7A lysine (K)-specific demethylase 7A -0.0360122
GSK3B glycogen synthase kinase 3 beta -0.0359205
SETD5 SET domain containing 5 -0.0357894
CDH17 cadherin 17, LI cadherin (liver-intestine) -0.0354979
MYH9 myosin, heavy chain 9, non-muscle -0.0352882
MBD5 methyl-CpG binding domain protein 5 -0.0352367
GOLGA4 golgin A4 -0.0349489
PUM2 pumilio RNA-binding family member 2 -0.0349428
PNISR PNN-interacting serine/arginine-rich protein -0.0349293
DLG1 discs, large homolog 1 (Drosophila) -0.0345555
EPCAM epithelial cell adhesion molecule -0.0341543
COG5 component of oligomeric golgi complex 5 -0.0341465
MACF1 microtubule-actin crosslinking factor 1 -0.0340672
FOXO1 forkhead box O1 -0.0339928
VCL vinculin -0.0336227
USP34 ubiquitin specific peptidase 34 -0.0334478
CD44 CD44 molecule (Indian blood group) -0.0330626
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0329961
MBNL2 muscleblind-like splicing regulator 2 -0.0328956
TRIM2 tripartite motif containing 2 -0.0328869
NF1 neurofibromin 1 -0.0328488
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0328461
CLTC clathrin, heavy chain (Hc) -0.0325598
RAB1A RAB1A, member RAS oncogene family -0.0324871
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0320336
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0319324
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0319061
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0319054
BIRC6 baculoviral IAP repeat containing 6 -0.0317668
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.031744
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0317045
ITPRID2 ITPR interacting domain containing 2 -0.0315049
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0313882
SERINC5 serine incorporator 5 -0.0311111
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0306814
ABHD2 abhydrolase domain containing 2 -0.0302654
IARS1 isoleucyl-tRNA synthetase 1 -0.0302024
TBC1D5 TBC1 domain family, member 5 -0.0301877
PTBP3 polypyrimidine tract binding protein 3 -0.0299885
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0296925
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0295935
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0294769
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0294695
ANKRD10 ankyrin repeat domain 10 -0.0294511
MARCHF6 membrane associated ring-CH-type finger 6 -0.0292745
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0292322
TFRC transferrin receptor -0.0290069
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0289925
METTL15 methyltransferase like 15 -0.0288359
SREBF2 sterol regulatory element binding transcription factor 2 -0.028779
CD46 CD46 molecule, complement regulatory protein -0.0287165
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0287122