| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tomivosertib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tomivosertib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS12 | ribosomal protein S12 | 0.0705164 |
| TP63 | tumor protein p63 | 0.0629198 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0593529 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0528935 |
| RPL37A | ribosomal protein L37a | 0.0493439 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.0459691 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0453733 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0393836 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0382907 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0335739 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0329676 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0327099 |
| HLA-A | major histocompatibility complex, class I, A | 0.0319774 |
| SP100 | SP100 nuclear antigen | 0.0308487 |
| JUN | jun proto-oncogene | 0.0299114 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0296936 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0292173 |
| VMP1 | vacuole membrane protein 1 | 0.0262884 |
| HLA-B | major histocompatibility complex, class I, B | 0.0262624 |
| POTEF | POTE ankyrin domain family, member F | 0.0260924 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0257447 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0255389 |
| CAPRIN2 | caprin family member 2 | 0.0250154 |
| HOMER1 | homer scaffolding protein 1 | 0.024653 |
| TRIM56 | tripartite motif containing 56 | 0.0246502 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0242772 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.024028 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0238332 |
| B2M | beta-2-microglobulin | 0.0233835 |
| RPS6 | ribosomal protein S6 | 0.0223089 |
| RPS3 | ribosomal protein S3 | 0.0222718 |
| RPS2 | ribosomal protein S2 | 0.0220987 |
| RPS8 | ribosomal protein S8 | 0.0220159 |
| RPS17 | ribosomal protein S17 | 0.0219655 |
| RPL31 | ribosomal protein L31 | 0.0218122 |
| PDE10A | phosphodiesterase 10A | 0.021728 |
| GOLGB1 | golgin B1 | 0.0216278 |
| HDAC9 | histone deacetylase 9 | 0.0210174 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0207993 |
| DST | dystonin | 0.0207344 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0202413 |
| RACK1 | receptor for activated C kinase 1 | 0.0202189 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0200588 |
| ANGPTL4 | angiopoietin-like 4 | 0.019961 |
| PCDH1 | protocadherin 1 | 0.0197751 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0197423 |
| DDX41 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | 0.0196586 |
| INTS6 | integrator complex subunit 6 | 0.01948 |
| TGM2 | transglutaminase 2 | 0.0190689 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0188416 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0187873 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0186759 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0181871 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0181826 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0179515 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0178982 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.017711 |
| EGR1 | early growth response 1 | 0.0176406 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0173744 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0173514 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0171921 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0166291 |
| PLSCR1 | phospholipid scramblase 1 | 0.0165781 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0163882 |
| UBC | ubiquitin C | 0.0163124 |
| RNF213 | ring finger protein 213 | 0.0162728 |
| EHBP1 | EH domain binding protein 1 | 0.0162606 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.0158283 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0157492 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0156301 |
| LYST | lysosomal trafficking regulator | 0.0156181 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0155725 |
| ARFGEF3 | ARFGEF family member 3 | 0.0155587 |
| PRELID2 | PRELI domain containing 2 | 0.0152513 |
| SQSTM1 | sequestosome 1 | 0.0151716 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.015021 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0149002 |
| VEGFA | vascular endothelial growth factor A | 0.0147916 |
| OFD1 | oral-facial-digital syndrome 1 | 0.0146729 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0146192 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0145399 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 0.0144845 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0144395 |
| WDR27 | WD repeat domain 27 | 0.0141738 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0141375 |
| TNS3 | tensin 3 | 0.0141138 |
| MCL1 | myeloid cell leukemia 1 | 0.0139844 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0139278 |
| HLA-E | major histocompatibility complex, class I, E | 0.0139072 |
| LRRC49 | leucine rich repeat containing 49 | 0.0138894 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0136105 |
| RAD51B | RAD51 paralog B | 0.013592 |
| OPTN | optineurin | 0.0135085 |
| ECE1 | endothelin converting enzyme 1 | 0.0133697 |
| ZNF638 | zinc finger protein 638 | 0.0133609 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0133486 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0133341 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0133146 |
| BRD2 | bromodomain containing 2 | 0.0133129 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.013266 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.322073 |
| PTMA | prothymosin, alpha | -0.217359 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.210241 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.172075 |
| VIM | vimentin | -0.140101 |
| TMSB4X | thymosin beta 4, X-linked | -0.11457 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.111507 |
| TMSB10 | thymosin beta 10 | -0.0914855 |
| CANX | calnexin | -0.0894965 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0865099 |
| AHNAK | AHNAK nucleoprotein | -0.0809866 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0794934 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0749133 |
| RAI1 | retinoic acid induced 1 | -0.073391 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0686898 |
| PGK1 | phosphoglycerate kinase 1 | -0.062789 |
| CENPF | centromere protein F, 350/400kDa | -0.0622108 |
| APP | amyloid beta (A4) precursor protein | -0.0619844 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0608262 |
| RBM39 | RNA binding motif protein 39 | -0.058943 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0586936 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0573238 |
| ACTG1 | actin gamma 1 | -0.0566682 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0552568 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0551621 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0532491 |
| ZNF217 | zinc finger protein 217 | -0.0513659 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0512937 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0508908 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0493622 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0482367 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0458121 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0456657 |
| TMEM123 | transmembrane protein 123 | -0.0453114 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0445556 |
| SPAG9 | sperm associated antigen 9 | -0.0433045 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0418627 |
| OGA | O-GlcNAcase | -0.0413871 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0413344 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.041065 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0408485 |
| WDR45B | WD repeat domain 45B | -0.0408395 |
| ZNF292 | zinc finger protein 292 | -0.0407893 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0400071 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0399093 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0394032 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0391655 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0383792 |
| ANLN | anillin, actin binding protein | -0.038343 |
| RTN4 | reticulon 4 | -0.0382817 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0382158 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0381144 |
| RPL35A | ribosomal protein L35a | -0.0377851 |
| SRPK2 | SRSF protein kinase 2 | -0.037145 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0368158 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0368005 |
| XPO1 | exportin 1 | -0.0359091 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0359026 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | -0.0356742 |
| CALR | calreticulin | -0.0355805 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0348509 |
| MATR3 | matrin 3 | -0.0348175 |
| YBX1 | Y box binding protein 1 | -0.0348113 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0347197 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0345915 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0345057 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0341772 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0335738 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0330276 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0328157 |
| ANXA2 | annexin A2 | -0.0325475 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0318121 |
| YBX3 | Y box binding protein 3 | -0.0316941 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0312002 |
| FUS | FUS RNA binding protein | -0.0311189 |
| TOP1 | topoisomerase (DNA) I | -0.0308804 |
| SRGN | serglycin | -0.0308477 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0305867 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0305733 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0305295 |
| MT1X | metallothionein 1X | -0.0302311 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0302179 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0301132 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0299443 |
| RPS24 | ribosomal protein S24 | -0.0297704 |
| S100A10 | S100 calcium binding protein A10 | -0.0295121 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0294349 |
| MTF2 | metal response element binding transcription factor 2 | -0.0293453 |
| OLA1 | Obg-like ATPase 1 | -0.0293366 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0293287 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0293203 |
| RLF | rearranged L-myc fusion | -0.0292606 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.029152 |
| HMGB2 | high mobility group box 2 | -0.0291254 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0290127 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0289727 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0289333 |
| STAG2 | stromal antigen 2 | -0.0289148 |
| TNPO1 | transportin 1 | -0.0289117 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0285292 |
