| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tomivosertib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tomivosertib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.315913 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.16226 |
| MT2A | metallothionein 2A | 0.138057 |
| TXNRD1 | thioredoxin reductase 1 | 0.0893034 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0873416 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.084929 |
| SLTM | SAFB-like, transcription modulator | 0.0769918 |
| RPS3 | ribosomal protein S3 | 0.0733345 |
| B2M | beta-2-microglobulin | 0.0624852 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0622948 |
| AREG | amphiregulin | 0.061151 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0561067 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0541386 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0517848 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0489109 |
| RPS12 | ribosomal protein S12 | 0.0485835 |
| FTL | ferritin, light polypeptide | 0.0483232 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0468883 |
| SEC61G | Sec61 gamma subunit | 0.0468329 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.046615 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0464204 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0461312 |
| STC1 | stanniocalcin 1 | 0.0449531 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0436249 |
| SIK3 | SIK family kinase 3 | 0.0429602 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0409764 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0397213 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0390943 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0378278 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0374401 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.036374 |
| YBX3 | Y box binding protein 3 | 0.0360722 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0353082 |
| ANKRD12 | ankyrin repeat domain 12 | 0.03509 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.035066 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0347894 |
| VMP1 | vacuole membrane protein 1 | 0.034641 |
| DSCAM | Down syndrome cell adhesion molecule | 0.034594 |
| HOMER1 | homer scaffolding protein 1 | 0.0340838 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0327302 |
| ENO1 | enolase 1, (alpha) | 0.0317946 |
| RPS6 | ribosomal protein S6 | 0.0313344 |
| SON | SON DNA binding protein | 0.0312771 |
| RPLP1 | ribosomal protein, large, P1 | 0.031034 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.030848 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0308269 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0305502 |
| CPE | carboxypeptidase E | 0.0301774 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0298994 |
| RPS8 | ribosomal protein S8 | 0.0298443 |
| IRS2 | insulin receptor substrate 2 | 0.0297583 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.029655 |
| SP100 | SP100 nuclear antigen | 0.0294382 |
| BRD2 | bromodomain containing 2 | 0.0292938 |
| CST3 | cystatin C | 0.0290717 |
| RPS2 | ribosomal protein S2 | 0.0290476 |
| TOP1 | topoisomerase (DNA) I | 0.0287803 |
| RACK1 | receptor for activated C kinase 1 | 0.0284071 |
| ARRDC3 | arrestin domain containing 3 | 0.0276239 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0275528 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0273254 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0270976 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0269314 |
| RPLP0 | ribosomal protein, large, P0 | 0.0268406 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0265108 |
| FOSL1 | FOS-like antigen 1 | 0.026331 |
| RPL37A | ribosomal protein L37a | 0.0261223 |
| PCBP2 | poly(rC) binding protein 2 | 0.0260123 |
| SYAP1 | synapse associated protein 1 | 0.0259712 |
| JMJD1C | jumonji domain containing 1C | 0.0249964 |
| DTNA | dystrobrevin, alpha | 0.0241759 |
| GOLGB1 | golgin B1 | 0.0241641 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0241306 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0240195 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0237961 |
| ZNF292 | zinc finger protein 292 | 0.0237597 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0236862 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0231884 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0231654 |
| RBM25 | RNA binding motif protein 25 | 0.0230184 |
| GPHN | gephyrin | 0.022915 |
| FAM13A | family with sequence similarity 13, member A | 0.0224863 |
| BPTF | bromodomain PHD finger transcription factor | 0.0223829 |
| RPL30 | ribosomal protein L30 | 0.0223336 |
| GPATCH2L | G patch domain containing 2-like | 0.0223191 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0221841 |
| RPS17 | ribosomal protein S17 | 0.0221076 |
| RUNX1 | runt-related transcription factor 1 | 0.0214583 |
| TPI1 | triosephosphate isomerase 1 | 0.0208902 |
| MT1X | metallothionein 1X | 0.0207899 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0205033 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0204266 |
| IFI44L | interferon-induced protein 44-like | 0.0203426 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0197806 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0196287 |
| MYO1B | myosin IB | 0.0195486 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0195181 |
| MLF1 | myeloid leukemia factor 1 | 0.0194485 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.019355 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0193398 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.219255 |
| ASPH | aspartate beta-hydroxylase | -0.190805 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.188623 |
| EGFR | epidermal growth factor receptor | -0.17073 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.129855 |
| AHNAK | AHNAK nucleoprotein | -0.110514 |
| LAMC2 | laminin, gamma 2 | -0.109127 |
| ACTG1 | actin gamma 1 | -0.10285 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0882545 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0825564 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0708935 |
| TMSB10 | thymosin beta 10 | -0.0707603 |
| H1-0 | H1.0 linker histone | -0.069274 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0670459 |
| KRT18 | keratin 18, type I | -0.0652628 |
| NDRG1 | N-myc downstream regulated 1 | -0.0633248 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0620053 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0573451 |
| LMO7 | LIM domain 7 | -0.0564156 |
| SCEL | sciellin | -0.0559532 |
| KRT7 | keratin 7, type II | -0.0542951 |
| ANXA2 | annexin A2 | -0.053734 |
| FLNB | filamin B, beta | -0.0537233 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0528445 |
| KRT8 | keratin 8, type II | -0.0524934 |
| HDLBP | high density lipoprotein binding protein | -0.051667 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0512986 |
| PTMA | prothymosin, alpha | -0.0486237 |
| PGK1 | phosphoglycerate kinase 1 | -0.0475449 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0471014 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.046759 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0453439 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0444484 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0413753 |
| PLEC | plectin | -0.0398595 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0398318 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0391469 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0389446 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0380363 |
| CANX | calnexin | -0.0373433 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0371746 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0366267 |
| VCL | vinculin | -0.0361113 |
| PRKCA | protein kinase C, alpha | -0.0357086 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.035522 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0353367 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0347573 |
| CUX1 | cut-like homeobox 1 | -0.0341472 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0339215 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0327568 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0325374 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0319279 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0317193 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0315707 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0315381 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0313638 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0311838 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0304633 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0302634 |
| DSPP | dentin sialophosphoprotein | -0.0300188 |
| USP34 | ubiquitin specific peptidase 34 | -0.0298566 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0297182 |
| DSG2 | desmoglein 2 | -0.0296945 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.029581 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0293074 |
| GOLGA3 | golgin A3 | -0.0288772 |
| RPS24 | ribosomal protein S24 | -0.0288597 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0285896 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0285407 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0285156 |
| NABP1 | nucleic acid binding protein 1 | -0.0284171 |
| CCND1 | cyclin D1 | -0.0280186 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0280118 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0278645 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0278218 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | -0.0276873 |
| AGR2 | anterior gradient 2 | -0.0270205 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0268224 |
| APP | amyloid beta (A4) precursor protein | -0.0267824 |
| EHBP1 | EH domain binding protein 1 | -0.0266724 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0263787 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0263575 |
| SDC4 | syndecan 4 | -0.0261315 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0260815 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | -0.0260474 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.025843 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0253365 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0251466 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0251339 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0244768 |
| FRYL | FRY-like | -0.0243924 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0243317 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0241136 |
| TPM4 | tropomyosin 4 | -0.0240268 |
| RAB10 | RAB10, member RAS oncogene family | -0.0238979 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0238072 |
| PTK2 | protein tyrosine kinase 2 | -0.0237923 |
| RIN2 | Ras and Rab interactor 2 | -0.023639 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0235532 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0234638 |
