| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tomivosertib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tomivosertib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.154619 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0786447 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0671117 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0639748 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0572392 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0499853 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0486409 |
| HLA-A | major histocompatibility complex, class I, A | 0.0472974 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0444171 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0422891 |
| FLNB | filamin B, beta | 0.0404287 |
| HLA-B | major histocompatibility complex, class I, B | 0.0401033 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.039363 |
| FMNL2 | formin-like 2 | 0.0393117 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0389689 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0378662 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0375002 |
| PYGL | phosphorylase, glycogen, liver | 0.0371877 |
| RPL37A | ribosomal protein L37a | 0.0358065 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0354455 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0329057 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0314695 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0313766 |
| NDRG1 | N-myc downstream regulated 1 | 0.030709 |
| EGFR | epidermal growth factor receptor | 0.0293759 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0287131 |
| FAM107B | family with sequence similarity 107, member B | 0.0283676 |
| GOLGB1 | golgin B1 | 0.027882 |
| HLA-E | major histocompatibility complex, class I, E | 0.0278521 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0272124 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0271745 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0271428 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0261834 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0261146 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0256742 |
| MYO1E | myosin IE | 0.0255974 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0254377 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0253579 |
| RPS6 | ribosomal protein S6 | 0.025071 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0250351 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0246758 |
| RPS8 | ribosomal protein S8 | 0.0245697 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0244076 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0241183 |
| ATXN1 | ataxin 1 | 0.0239186 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0236777 |
| IER3 | immediate early response 3 | 0.023547 |
| MT1F | metallothionein 1F | 0.0233823 |
| ANGPTL4 | angiopoietin-like 4 | 0.0233478 |
| CDCP1 | CUB domain containing protein 1 | 0.0233056 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0232247 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0229735 |
| IL6 | interleukin 6 | 0.0229512 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.02292 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0228517 |
| CTBP2 | C-terminal binding protein 2 | 0.0220358 |
| SVIL | supervillin | 0.0219311 |
| GOLGA4 | golgin A4 | 0.0218796 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.021712 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.021666 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0214999 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0212648 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0211687 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0210351 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0210272 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0207878 |
| CYTH1 | cytohesin 1 | 0.0206678 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0206487 |
| CD44 | CD44 molecule (Indian blood group) | 0.0205193 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0204599 |
| INHBA | inhibin, beta A | 0.0202528 |
| INTS6 | integrator complex subunit 6 | 0.0199027 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0197642 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.01957 |
| MED13 | mediator complex subunit 13 | 0.0195626 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0195337 |
| USP36 | ubiquitin specific peptidase 36 | 0.0194156 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0193307 |
| LAMC2 | laminin, gamma 2 | 0.0192983 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0188754 |
| ATF4 | activating transcription factor 4 | 0.0187183 |
| KIF13A | kinesin family member 13A | 0.0186085 |
| RPL31 | ribosomal protein L31 | 0.0185073 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0184904 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0182556 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0180783 |
| NUMB | numb homolog (Drosophila) | 0.0179149 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0177572 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0175955 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0173811 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0171218 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 0.0169658 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0169647 |
| NF1 | neurofibromin 1 | 0.0169405 |
| COPA | coatomer protein complex, subunit alpha | 0.016799 |
| MCL1 | myeloid cell leukemia 1 | 0.0167563 |
| SBF2 | SET binding factor 2 | 0.016401 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0163157 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | 0.0159549 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.0157828 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.21821 |
| FTL | ferritin, light polypeptide | -0.204781 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.196942 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.183648 |
| TMSB10 | thymosin beta 10 | -0.183329 |
| TXNRD1 | thioredoxin reductase 1 | -0.151894 |
| PM20D1 | peptidase M20 domain containing 1 | -0.1372 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.116085 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0898404 |
| PTMA | prothymosin, alpha | -0.0814023 |
| FGB | fibrinogen beta chain | -0.0812654 |
| GRAMD1B | GRAM domain containing 1B | -0.0809421 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0779623 |
| RTN4 | reticulon 4 | -0.0753889 |
| RPL19 | ribosomal protein L19 | -0.0665416 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.064876 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0638803 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0585776 |
| PFN1 | profilin 1 | -0.0565218 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0558986 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0529922 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0526408 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0522026 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0521911 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0512843 |
| YBX1 | Y box binding protein 1 | -0.0484215 |
| RPLP0 | ribosomal protein, large, P0 | -0.0476102 |
| HMGA1 | high mobility group AT-hook 1 | -0.0470637 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0470595 |
| PKM | pyruvate kinase, muscle | -0.0446644 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0434398 |
| TPM3 | tropomyosin 3 | -0.0429815 |
| ACTG1 | actin gamma 1 | -0.0426904 |
| TMEM123 | transmembrane protein 123 | -0.0426778 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0411152 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0404675 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0398047 |
| USP3 | ubiquitin specific peptidase 3 | -0.0395628 |
| VIM | vimentin | -0.0387987 |
| RPL8 | ribosomal protein L8 | -0.0379925 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0371631 |
| ASPH | aspartate beta-hydroxylase | -0.03708 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0369942 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0366684 |
| RPL23 | ribosomal protein L23 | -0.0360998 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0358502 |
| ANXA2 | annexin A2 | -0.0352787 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0347732 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0347596 |
| RPS5 | ribosomal protein S5 | -0.0347209 |
| TAGLN2 | transgelin 2 | -0.0344263 |
| HMGB1 | high mobility group box 1 | -0.0343651 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0343366 |
| ECT2 | epithelial cell transforming 2 | -0.0342671 |
| CHN1 | chimerin 1 | -0.0340716 |
| FGG | fibrinogen gamma chain | -0.0336362 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0335308 |
| YBX3 | Y box binding protein 3 | -0.0334751 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0331975 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0331044 |
| ERBIN | erbb2 interacting protein | -0.0330052 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0329342 |
| ENAH | enabled homolog (Drosophila) | -0.0317288 |
| BICC1 | BicC family RNA binding protein 1 | -0.031574 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0314191 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0313646 |
| RPS21 | ribosomal protein S21 | -0.0313342 |
| RBM39 | RNA binding motif protein 39 | -0.031146 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0311158 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0309404 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0308512 |
| RPS19 | ribosomal protein S19 | -0.030846 |
| ANLN | anillin, actin binding protein | -0.0302808 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0299363 |
| SERF2 | small EDRK-rich factor 2 | -0.0292268 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0290768 |
| PFDN2 | prefoldin subunit 2 | -0.0289608 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.02883 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0287382 |
| RHOA | ras homolog family member A | -0.0286826 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0279362 |
| RHEB | Ras homolog enriched in brain | -0.0279359 |
| CALR | calreticulin | -0.0279102 |
| TUBB | tubulin, beta class I | -0.0278133 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0276841 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0276524 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0276327 |
| TPX2 | TPX2, microtubule-associated | -0.0275935 |
| TNPO1 | transportin 1 | -0.0275097 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0272038 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | -0.0271575 |
| RPL7 | ribosomal protein L7 | -0.0266897 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0266598 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0265487 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0265105 |
| WWOX | WW domain containing oxidoreductase | -0.0257296 |
| LDHB | lactate dehydrogenase B | -0.0255509 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0254495 |
| MORF4L1 | mortality factor 4 like 1 | -0.0254139 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0253613 |
