| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tomivosertib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tomivosertib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.143108 |
| VIM | vimentin | 0.136543 |
| LAMA4 | laminin, alpha 4 | 0.114927 |
| MT2A | metallothionein 2A | 0.114427 |
| B2M | beta-2-microglobulin | 0.112458 |
| IGF2 | insulin-like growth factor 2 | 0.105949 |
| FTL | ferritin, light polypeptide | 0.098195 |
| RPS6 | ribosomal protein S6 | 0.0930037 |
| NDRG1 | N-myc downstream regulated 1 | 0.0821796 |
| KYNU | kynureninase | 0.0820057 |
| TMSB10 | thymosin beta 10 | 0.0818624 |
| TXNRD1 | thioredoxin reductase 1 | 0.0798503 |
| POTEF | POTE ankyrin domain family, member F | 0.0795348 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0749768 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0726033 |
| RACK1 | receptor for activated C kinase 1 | 0.0691887 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0686069 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0683283 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0664404 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0647099 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0640442 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0637281 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0633199 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0626065 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0625028 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.061985 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0613913 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0612845 |
| KRT17 | keratin 17, type I | 0.0612122 |
| SP100 | SP100 nuclear antigen | 0.0608714 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0602759 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0596275 |
| PERP | PERP, TP53 apoptosis effector | 0.0583382 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0582538 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0571798 |
| INHBA | inhibin, beta A | 0.0565057 |
| RPS8 | ribosomal protein S8 | 0.0549629 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0544343 |
| USP34 | ubiquitin specific peptidase 34 | 0.054161 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.053422 |
| RPL31 | ribosomal protein L31 | 0.053218 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0528992 |
| RPL37 | ribosomal protein L37 | 0.052558 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0509332 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0509134 |
| RPL15 | ribosomal protein L15 | 0.0502264 |
| RBM25 | RNA binding motif protein 25 | 0.0500524 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0497302 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0489803 |
| ENO1 | enolase 1, (alpha) | 0.0488856 |
| BPTF | bromodomain PHD finger transcription factor | 0.0483852 |
| NSRP1 | nuclear speckle splicing regulatory protein 1 | 0.0479071 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.04635 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.046162 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0458792 |
| RPS12 | ribosomal protein S12 | 0.04567 |
| RNF145 | ring finger protein 145 | 0.0448585 |
| RIGI | RNA sensor RIG-I | 0.0441434 |
| GOLGA4 | golgin A4 | 0.0440074 |
| RPS3 | ribosomal protein S3 | 0.0439532 |
| WTAP | Wilms tumor 1 associated protein | 0.0435655 |
| RPL37A | ribosomal protein L37a | 0.0435254 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0423191 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0411072 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0408591 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0407576 |
| RPL26 | ribosomal protein L26 | 0.0406902 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0403191 |
| RPL23 | ribosomal protein L23 | 0.0400476 |
| INTS6 | integrator complex subunit 6 | 0.0397264 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0390096 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0389289 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0387449 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0384364 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0383923 |
| EFNA5 | ephrin-A5 | 0.0379532 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0373957 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0372835 |
| RPS27 | ribosomal protein S27 | 0.0369494 |
| COG5 | component of oligomeric golgi complex 5 | 0.0369172 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.036813 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.036138 |
| RPS20 | ribosomal protein S20 | 0.036067 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0358693 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0351657 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0350881 |
| ABLIM1 | actin binding LIM protein 1 | 0.0348619 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0347751 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0347239 |
| RUNX1 | runt-related transcription factor 1 | 0.0344228 |
| FLNB | filamin B, beta | 0.0342522 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.034167 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0338062 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0336029 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0333905 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0332747 |
| RPLP2 | ribosomal protein, large, P2 | 0.0332067 |
| LIMA1 | LIM domain and actin binding 1 | 0.0331688 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0330358 |
| RPL5 | ribosomal protein L5 | 0.032805 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.163538 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.155696 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.146104 |
| MYO1E | myosin IE | -0.121582 |
| LAMC2 | laminin, gamma 2 | -0.115782 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0920026 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0779762 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0779303 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0706099 |
| ATOSA | atos homolog A | -0.0704753 |
| IGF1R | insulin-like growth factor 1 receptor | -0.065424 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0644651 |
| SVIL | supervillin | -0.0635763 |
| AHNAK | AHNAK nucleoprotein | -0.0635046 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.0612752 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0608567 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0588333 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0582513 |
| MMP1 | matrix metallopeptidase 1 | -0.0555245 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0541538 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0539803 |
| PARD3 | par-3 family cell polarity regulator | -0.0536521 |
| TC2N | tandem C2 domains, nuclear | -0.053167 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0509606 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0505352 |
| ANXA2 | annexin A2 | -0.0500147 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0489953 |
| RESF1 | retroelement silencing factor 1 | -0.0480767 |
| SMYD3 | SET and MYND domain containing 3 | -0.046634 |
| RORA | RAR-related orphan receptor A | -0.0455466 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0448236 |
| SETX | senataxin | -0.0442577 |
| GPC6 | glypican 6 | -0.0438027 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0434107 |
| PLEC | plectin | -0.0420168 |
| OXR1 | oxidation resistance 1 | -0.0417763 |
| RBM39 | RNA binding motif protein 39 | -0.0416417 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0416342 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0412027 |
| CMIP | c-Maf inducing protein | -0.0407925 |
| ZNF217 | zinc finger protein 217 | -0.0405536 |
| TAOK3 | TAO kinase 3 | -0.0404911 |
| C1D | C1D nuclear receptor corepressor | -0.0402635 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0402057 |
| SDCBP2 | syndecan binding protein (syntenin) 2 | -0.0400975 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0400513 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0400195 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0394195 |
| TMCC3 | transmembrane and coiled-coil domain family 3 | -0.0393943 |
| CNKSR3 | CNKSR family member 3 | -0.0392792 |
| SEPTIN10 | septin 10 | -0.039093 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0389368 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0389275 |
| DIAPH2 | diaphanous-related formin 2 | -0.0384304 |
| MYO10 | myosin X | -0.0380551 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0379404 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0379025 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0376181 |
| ZNF185 | zinc finger protein 185 (LIM domain) | -0.0374044 |
| NUMB | numb homolog (Drosophila) | -0.0372704 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0370509 |
| MUC16 | mucin 16, cell surface associated | -0.0369667 |
| RBM47 | RNA binding motif protein 47 | -0.0369654 |
| TBL1X | transducin (beta)-like 1X-linked | -0.0369606 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0366878 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0365061 |
| FOXO1 | forkhead box O1 | -0.0363058 |
| RLIM | ring finger protein, LIM domain interacting | -0.0360522 |
| WASL | Wiskott-Aldrich syndrome-like | -0.0358393 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0354337 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.035243 |
| EMP1 | epithelial membrane protein 1 | -0.0350483 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | -0.0348262 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0345847 |
| ITGB4 | integrin, beta 4 | -0.0344692 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0344268 |
| SDC4 | syndecan 4 | -0.03439 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0342894 |
| NSD3 | nuclear receptor binding SET domain protein 3 | -0.034222 |
| CD9 | CD9 molecule | -0.0341566 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0341547 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0340889 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | -0.0335871 |
| TPCN1 | two pore segment channel 1 | -0.0333851 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0333318 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0331257 |
| AK1 | adenylate kinase 1 | -0.0330476 |
| HMGA2 | high mobility group AT-hook 2 | -0.0329461 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.0327859 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | -0.0327714 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0327308 |
| EXOC1 | exocyst complex component 1 | -0.0326766 |
| NABP1 | nucleic acid binding protein 1 | -0.0324326 |
| SH3PXD2A | SH3 and PX domains 2A | -0.0322972 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0321565 |
| TRIP11 | thyroid hormone receptor interactor 11 | -0.0317156 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0316051 |
| CDK13 | cyclin-dependent kinase 13 | -0.031552 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.031399 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0313029 |
