| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tomivosertib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tomivosertib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.27268 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0981137 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0947079 |
| RPL37A | ribosomal protein L37a | 0.064029 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0617971 |
| RPS3 | ribosomal protein S3 | 0.0611455 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0605788 |
| RPS12 | ribosomal protein S12 | 0.0509546 |
| RPS8 | ribosomal protein S8 | 0.0507599 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0484546 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0469533 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0450534 |
| GOLGB1 | golgin B1 | 0.0415686 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0404456 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0395173 |
| INTS6 | integrator complex subunit 6 | 0.0393945 |
| HOMER1 | homer scaffolding protein 1 | 0.0389955 |
| BRD2 | bromodomain containing 2 | 0.0380982 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0368915 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0367201 |
| RPS17 | ribosomal protein S17 | 0.0366876 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0364565 |
| RPS2 | ribosomal protein S2 | 0.0346787 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0340955 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0340913 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0340814 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0340237 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0334587 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0332433 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0318497 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0317876 |
| POTEF | POTE ankyrin domain family, member F | 0.0316875 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0307611 |
| WDR43 | WD repeat domain 43 | 0.0290065 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0287742 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0286707 |
| RPS6 | ribosomal protein S6 | 0.0284127 |
| RACK1 | receptor for activated C kinase 1 | 0.0282988 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.028038 |
| DST | dystonin | 0.0273875 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0271362 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0270071 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0263098 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0262819 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0258831 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0253959 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | 0.0251248 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.024968 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0245666 |
| TOP1 | topoisomerase (DNA) I | 0.0243137 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0240095 |
| NRG1 | neuregulin 1 | 0.0235815 |
| IER3 | immediate early response 3 | 0.0232931 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0231234 |
| SVIL | supervillin | 0.0230253 |
| AEBP2 | AE binding protein 2 | 0.0228213 |
| TPI1 | triosephosphate isomerase 1 | 0.0226818 |
| RPS26 | ribosomal protein S26 | 0.0225966 |
| PTBP1 | polypyrimidine tract binding protein 1 | 0.0223081 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0223032 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.0221546 |
| SIK3 | SIK family kinase 3 | 0.0220737 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0214999 |
| RPL5 | ribosomal protein L5 | 0.0210768 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0210173 |
| RPL31 | ribosomal protein L31 | 0.0209763 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.020962 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0207143 |
| WWOX | WW domain containing oxidoreductase | 0.0201561 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0200681 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0199371 |
| ATF6 | activating transcription factor 6 | 0.0198841 |
| FNDC3A | fibronectin type III domain containing 3A | 0.019484 |
| RPS27 | ribosomal protein S27 | 0.0192139 |
| RPL27 | ribosomal protein L27 | 0.0191684 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0191311 |
| SQSTM1 | sequestosome 1 | 0.0190947 |
| THOC2 | THO complex 2 | 0.0189874 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0189713 |
| HLA-A | major histocompatibility complex, class I, A | 0.018842 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0188198 |
| RPL36 | ribosomal protein L36 | 0.0187142 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0185745 |
| RPL9 | ribosomal protein L9 | 0.018212 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0181743 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0181211 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0179254 |
| RPL26 | ribosomal protein L26 | 0.0178935 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0178809 |
| B2M | beta-2-microglobulin | 0.0177782 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.017614 |
| PRDX1 | peroxiredoxin 1 | 0.0175953 |
| IER2 | immediate early response 2 | 0.017538 |
| NEK10 | NIMA-related kinase 10 | 0.0175288 |
| ZC3H13 | zinc finger CCCH-type containing 13 | 0.01741 |
| RBM25 | RNA binding motif protein 25 | 0.0173768 |
| TRIM59 | tripartite motif containing 59 | 0.0172839 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0172222 |
| MYO10 | myosin X | 0.0171397 |
| CREM | cAMP responsive element modulator | 0.0168845 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.212553 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.181517 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0925858 |
| RBM39 | RNA binding motif protein 39 | -0.0847546 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0798819 |
| PTMA | prothymosin, alpha | -0.0770222 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.076846 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0767568 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0718401 |
| RAD51B | RAD51 paralog B | -0.0699548 |
| BBX | bobby sox homolog (Drosophila) | -0.0677545 |
| PHIP | pleckstrin homology domain interacting protein | -0.0666954 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0653313 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0642847 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0596273 |
| OGA | O-GlcNAcase | -0.0581109 |
| XPO1 | exportin 1 | -0.0579535 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0570556 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0564412 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0560354 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0554867 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0540584 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0537747 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0524749 |
| TMEM165 | transmembrane protein 165 | -0.0523985 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0499214 |
| PGK1 | phosphoglycerate kinase 1 | -0.0493019 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0479319 |
| SBF2 | SET binding factor 2 | -0.0476862 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0471529 |
| PFN1 | profilin 1 | -0.0467231 |
| RTN4 | reticulon 4 | -0.0465868 |
| ZNF207 | zinc finger protein 207 | -0.0463629 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.045949 |
| USP34 | ubiquitin specific peptidase 34 | -0.0458251 |
| PHF20 | PHD finger protein 20 | -0.0456848 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0454311 |
| AHNAK | AHNAK nucleoprotein | -0.045185 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0451508 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0449848 |
| CD2AP | CD2-associated protein | -0.0445636 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0445179 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0440594 |
| TNPO3 | transportin 3 | -0.043997 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0438761 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.043678 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0422756 |
| MED13L | mediator complex subunit 13-like | -0.0418877 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0414503 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0413274 |
| TFG | TRK-fused gene | -0.0410563 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0397892 |
| CCNL1 | cyclin L1 | -0.0397077 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0379804 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0377483 |
| IGF2 | insulin-like growth factor 2 | -0.0374812 |
| COG5 | component of oligomeric golgi complex 5 | -0.0370318 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0366705 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.036632 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.036482 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0363579 |
| HMGA1 | high mobility group AT-hook 1 | -0.0363371 |
| RSF1 | remodeling and spacing factor 1 | -0.0362156 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0362106 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0361232 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0360596 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0359247 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0358978 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0350905 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.035083 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0348002 |
| ETNK1 | ethanolamine kinase 1 | -0.0347582 |
| PHF21A | PHD finger protein 21A | -0.0346188 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0343852 |
| KRT18 | keratin 18, type I | -0.0343625 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0343015 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0342458 |
| SETD5 | SET domain containing 5 | -0.0342249 |
| WASF2 | WAS protein family, member 2 | -0.034177 |
| CEP192 | centrosomal protein 192kDa | -0.0340791 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0339934 |
| H1-0 | H1.0 linker histone | -0.0339007 |
| PCNX1 | pecanex 1 | -0.0336733 |
| WDR45B | WD repeat domain 45B | -0.0335751 |
| PCBP2 | poly(rC) binding protein 2 | -0.0334303 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0334145 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0333257 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0333226 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0330352 |
| TMSB10 | thymosin beta 10 | -0.0330038 |
| RPLP0 | ribosomal protein, large, P0 | -0.032731 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0323812 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0322307 |
| KPNB1 | karyopherin (importin) beta 1 | -0.032015 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0318247 |
| CANX | calnexin | -0.0317871 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0316084 |
| DENND5B | DENN/MADD domain containing 5B | -0.0312883 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0310104 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0309991 |
