| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tomivosertib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tomivosertib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.283081 |
| POTEF | POTE ankyrin domain family, member F | 0.183398 |
| FTL | ferritin, light polypeptide | 0.144702 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.129687 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.117031 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.114963 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0987607 |
| RACK1 | receptor for activated C kinase 1 | 0.0738851 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0707238 |
| RPS3 | ribosomal protein S3 | 0.0702742 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0660802 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0637665 |
| ARRDC3 | arrestin domain containing 3 | 0.0615679 |
| RPS12 | ribosomal protein S12 | 0.0548541 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.053292 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.052283 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0492869 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0484306 |
| RPS6 | ribosomal protein S6 | 0.0461787 |
| BRD2 | bromodomain containing 2 | 0.0459767 |
| MT2A | metallothionein 2A | 0.0453265 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0433492 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0432646 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0431763 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0415766 |
| RPS2 | ribosomal protein S2 | 0.0405412 |
| EGR1 | early growth response 1 | 0.0387657 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.037464 |
| RPS8 | ribosomal protein S8 | 0.0369714 |
| TXNIP | thioredoxin interacting protein | 0.0368147 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0359092 |
| VMP1 | vacuole membrane protein 1 | 0.0353923 |
| RPS17 | ribosomal protein S17 | 0.0342149 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0340008 |
| RBM25 | RNA binding motif protein 25 | 0.0338653 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0338113 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0335383 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.033391 |
| SGMS2 | sphingomyelin synthase 2 | 0.0329254 |
| CBX3 | chromobox homolog 3 | 0.0323645 |
| AREG | amphiregulin | 0.0315611 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0310928 |
| RPLP0 | ribosomal protein, large, P0 | 0.0310724 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0307376 |
| DSTN | destrin (actin depolymerizing factor) | 0.0302882 |
| TXNRD1 | thioredoxin reductase 1 | 0.0292202 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0291485 |
| GPX4 | glutathione peroxidase 4 | 0.0284713 |
| RPS19 | ribosomal protein S19 | 0.0283976 |
| RPL37 | ribosomal protein L37 | 0.0277705 |
| RPLP2 | ribosomal protein, large, P2 | 0.0275392 |
| RPL9 | ribosomal protein L9 | 0.0273306 |
| CLDN4 | claudin 4 | 0.027012 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0269563 |
| G0S2 | G0/G1 switch 2 | 0.0269275 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0264982 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0263914 |
| RPL12 | ribosomal protein L12 | 0.0263755 |
| RPL37A | ribosomal protein L37a | 0.0259537 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.025947 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0258411 |
| RPL18 | ribosomal protein L18 | 0.0253435 |
| ENO1 | enolase 1, (alpha) | 0.0252656 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.025257 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0252193 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0249574 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.024931 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0247459 |
| RPS14 | ribosomal protein S14 | 0.0246533 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0244318 |
| IFI44L | interferon-induced protein 44-like | 0.0243061 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0241693 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0234255 |
| TPI1 | triosephosphate isomerase 1 | 0.0231367 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0230956 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0229485 |
| SON | SON DNA binding protein | 0.0224575 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0222205 |
| PLP2 | proteolipid protein 2 (colonic epithelium-enriched) | 0.0218836 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0218585 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0217815 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0217626 |
| PCBP2 | poly(rC) binding protein 2 | 0.0215132 |
| LDHB | lactate dehydrogenase B | 0.020947 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.0206557 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0206501 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.0203905 |
| COX6C | cytochrome c oxidase subunit VIc | 0.0198891 |
| GRAMD2B | GRAM domain containing 2B | 0.0198724 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0198235 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0196697 |
| RPL30 | ribosomal protein L30 | 0.0196213 |
| RPL5 | ribosomal protein L5 | 0.0195524 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0193664 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0190984 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0190801 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0190581 |
| TJP1 | tight junction protein 1 | 0.0188906 |
| SCFD1 | sec1 family domain containing 1 | 0.0188551 |
| DUSP6 | dual specificity phosphatase 6 | 0.0187217 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.302634 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.136396 |
| AHNAK | AHNAK nucleoprotein | -0.128552 |
| PTMA | prothymosin, alpha | -0.126423 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.122516 |
| GRB10 | growth factor receptor-bound protein 10 | -0.108779 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.103362 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0945198 |
| ACTG1 | actin gamma 1 | -0.0928146 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0815586 |
| CANX | calnexin | -0.0795749 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0723323 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0693612 |
| FBXO32 | F-box protein 32 | -0.0669427 |
| PGK1 | phosphoglycerate kinase 1 | -0.0665409 |
| PLEC | plectin | -0.0642983 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0642212 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0622478 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0615931 |
| LAMC2 | laminin, gamma 2 | -0.0600337 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0596359 |
| ANXA2 | annexin A2 | -0.0591884 |
| PTK2 | protein tyrosine kinase 2 | -0.0582937 |
| RBM39 | RNA binding motif protein 39 | -0.0571339 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0559843 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0550412 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.054459 |
| TMEM123 | transmembrane protein 123 | -0.0524715 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0521857 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0520979 |
| FLNB | filamin B, beta | -0.0513307 |
| CCND1 | cyclin D1 | -0.0508842 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0508418 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.050681 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0494254 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.049244 |
| ASPH | aspartate beta-hydroxylase | -0.0484823 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0467087 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0464886 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0455486 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0452881 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0441541 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0431281 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0425616 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.042488 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0418591 |
| MSI2 | musashi RNA-binding protein 2 | -0.0412989 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0409653 |
| KRT8 | keratin 8, type II | -0.0401198 |
| NDRG1 | N-myc downstream regulated 1 | -0.0400442 |
| S100A10 | S100 calcium binding protein A10 | -0.0391787 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0389381 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0384463 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0383894 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0379339 |
| CD2AP | CD2-associated protein | -0.0369003 |
| DSG2 | desmoglein 2 | -0.036834 |
| FBXO34 | F-box protein 34 | -0.0366845 |
| NAV2 | neuron navigator 2 | -0.0359495 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0355794 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0351161 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | -0.0347685 |
| SPAG9 | sperm associated antigen 9 | -0.0347369 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0345852 |
| OGA | O-GlcNAcase | -0.0344868 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0344046 |
| ZNF207 | zinc finger protein 207 | -0.0343568 |
| RHOA | ras homolog family member A | -0.0342646 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0339701 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0335779 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0333962 |
| ZNF217 | zinc finger protein 217 | -0.03291 |
| HDLBP | high density lipoprotein binding protein | -0.0323036 |
| RAI14 | retinoic acid induced 14 | -0.0317685 |
| CALR | calreticulin | -0.0317544 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0315604 |
| PARD3 | par-3 family cell polarity regulator | -0.031408 |
| TPM4 | tropomyosin 4 | -0.0312806 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0312603 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0309891 |
| KRT18 | keratin 18, type I | -0.0308295 |
| RCOR1 | REST corepressor 1 | -0.0306346 |
| CTSD | cathepsin D | -0.0304329 |
| LAMB3 | laminin, beta 3 | -0.0303431 |
| CTSB | cathepsin B | -0.0302785 |
| CTBP2 | C-terminal binding protein 2 | -0.0299949 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0299901 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.029971 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.0297412 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0296542 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0295712 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0294054 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0291471 |
| CAB39 | calcium binding protein 39 | -0.0290779 |
| ERBIN | erbb2 interacting protein | -0.0290096 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0289627 |
| IRF6 | interferon regulatory factor 6 | -0.0288538 |
| MCU | mitochondrial calcium uniporter | -0.0288384 |
| STAG2 | stromal antigen 2 | -0.0287875 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0286933 |
