| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tomivosertib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tomivosertib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0876568 |
| RPS6 | ribosomal protein S6 | 0.0634 |
| RPS12 | ribosomal protein S12 | 0.0452236 |
| RPS8 | ribosomal protein S8 | 0.0408885 |
| RPL37A | ribosomal protein L37a | 0.0391699 |
| VIM | vimentin | 0.0388609 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0365473 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0323715 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.0319221 |
| RPL31 | ribosomal protein L31 | 0.0275974 |
| RPS17 | ribosomal protein S17 | 0.0262456 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.026243 |
| RGS2 | regulator of G-protein signaling 2 | 0.0250699 |
| RPS3 | ribosomal protein S3 | 0.0242819 |
| LSAMP | limbic system-associated membrane protein | 0.0238299 |
| RACK1 | receptor for activated C kinase 1 | 0.023801 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0225264 |
| SQSTM1 | sequestosome 1 | 0.0222074 |
| RPL9 | ribosomal protein L9 | 0.0220964 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0216583 |
| RPL26 | ribosomal protein L26 | 0.0215573 |
| RAD51B | RAD51 paralog B | 0.0208685 |
| RPS2 | ribosomal protein S2 | 0.0204205 |
| DST | dystonin | 0.0203167 |
| MAP7 | microtubule-associated protein 7 | 0.0194355 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0193684 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0189906 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0178559 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0177179 |
| RPS27 | ribosomal protein S27 | 0.0171249 |
| CDH13 | cadherin 13 | 0.0170758 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0169528 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.016654 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0162836 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0159755 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0158671 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0158275 |
| POTEF | POTE ankyrin domain family, member F | 0.0157903 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.01541 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0144168 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0141577 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0138623 |
| NRXN3 | neurexin 3 | 0.0135049 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0133595 |
| SVIL | supervillin | 0.0133547 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0126374 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0126166 |
| RPL37 | ribosomal protein L37 | 0.0123164 |
| INTS6 | integrator complex subunit 6 | 0.0122878 |
| SMAD2 | SMAD family member 2 | 0.0122561 |
| HLA-A | major histocompatibility complex, class I, A | 0.0119938 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0119685 |
| PRELID2 | PRELI domain containing 2 | 0.0119593 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0115312 |
| ENO1 | enolase 1, (alpha) | 0.0114467 |
| WWOX | WW domain containing oxidoreductase | 0.0113392 |
| RPL12 | ribosomal protein L12 | 0.0113282 |
| GPHN | gephyrin | 0.0111929 |
| XYLT1 | xylosyltransferase I | 0.0110842 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0110613 |
| RPL27 | ribosomal protein L27 | 0.0107355 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.010446 |
| MT2A | metallothionein 2A | 0.0102982 |
| GOLGB1 | golgin B1 | 0.0102548 |
| RPS19 | ribosomal protein S19 | 0.0102402 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0100888 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0100545 |
| RAB3B | RAB3B, member RAS oncogene family | 0.00984429 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.00979413 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.00974484 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.00933205 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.00931067 |
| RPS13 | ribosomal protein S13 | 0.00927448 |
| TENM2 | teneurin transmembrane protein 2 | 0.00922134 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.00910237 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.00905814 |
| ZFP36 | ZFP36 ring finger protein | 0.00905302 |
| FAM107B | family with sequence similarity 107, member B | 0.00903157 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.00901722 |
| PKM | pyruvate kinase, muscle | 0.00894802 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.00891547 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 0.00889871 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.00869685 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.00859031 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.00855305 |
| RPS14 | ribosomal protein S14 | 0.00853674 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.00848424 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.00847528 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.00821229 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.00816311 |
| RPS23 | ribosomal protein S23 | 0.00802241 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.00794504 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.00787491 |
| RPLP0 | ribosomal protein, large, P0 | 0.00784519 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | 0.0077661 |
| DSTN | destrin (actin depolymerizing factor) | 0.00772443 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.00771903 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.00770036 |
| SET | SET nuclear proto-oncogene | 0.00766342 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.00763123 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.144715 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.118562 |
| FN1 | fibronectin 1 | -0.112581 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0987017 |
| EFNA5 | ephrin-A5 | -0.0770305 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0750969 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0733654 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0560663 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0551093 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0528573 |
| ASPH | aspartate beta-hydroxylase | -0.0513851 |
| GDA | guanine deaminase | -0.0491135 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0467375 |
| TMSB10 | thymosin beta 10 | -0.0429735 |
| SPAG9 | sperm associated antigen 9 | -0.0419653 |
| RBM39 | RNA binding motif protein 39 | -0.037197 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0357585 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0349894 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.034262 |
| RTN4 | reticulon 4 | -0.0334244 |
| PGK1 | phosphoglycerate kinase 1 | -0.0331713 |
| OGA | O-GlcNAcase | -0.0328021 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.032551 |
| TXNRD1 | thioredoxin reductase 1 | -0.032443 |
| CANX | calnexin | -0.0322186 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0315104 |
| NEK7 | NIMA-related kinase 7 | -0.0304785 |
| PTMA | prothymosin, alpha | -0.0304765 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.0302702 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0297486 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0294819 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0275355 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0266874 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0263652 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0261229 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.025374 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.025074 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0247573 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0242082 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0238072 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0228381 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0228004 |
| WDR45B | WD repeat domain 45B | -0.0226275 |
| NRCAM | neuronal cell adhesion molecule | -0.022512 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0222732 |
| SMYD3 | SET and MYND domain containing 3 | -0.0217791 |
| PDE10A | phosphodiesterase 10A | -0.021446 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0213302 |
| USP3 | ubiquitin specific peptidase 3 | -0.0212526 |
| LAMA1 | laminin, alpha 1 | -0.0210279 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0209751 |
| PCBP3 | poly(rC) binding protein 3 | -0.0207813 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0207581 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0204404 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0203026 |
| GNAS | GNAS complex locus | -0.0200032 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0193015 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0191972 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0191723 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0191461 |
| GRAMD1B | GRAM domain containing 1B | -0.0188965 |
| MCL1 | myeloid cell leukemia 1 | -0.0188907 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0188012 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.018534 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0184931 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0184929 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0184245 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0182969 |
| IGF1R | insulin-like growth factor 1 receptor | -0.018172 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0181068 |
| SRPK2 | SRSF protein kinase 2 | -0.0180787 |
| S100A6 | S100 calcium binding protein A6 | -0.0174908 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0173423 |
| PYGL | phosphorylase, glycogen, liver | -0.0173263 |
| GOLGA4 | golgin A4 | -0.0172819 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -0.017166 |
| NUP58 | nucleoporin 58 | -0.0170817 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0169842 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0168903 |
| NDRG1 | N-myc downstream regulated 1 | -0.0164924 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0164472 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.016429 |
| HELZ | helicase with zinc finger | -0.0163421 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0163037 |
| APP | amyloid beta (A4) precursor protein | -0.0162673 |
| ZNF207 | zinc finger protein 207 | -0.0161334 |
| MATR3 | matrin 3 | -0.0160495 |
| OSMR | oncostatin M receptor | -0.0159864 |
| BMERB1 | bMERB domain containing 1 | -0.015891 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0157513 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0156392 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.015583 |
| CALR | calreticulin | -0.0155462 |
| RAI1 | retinoic acid induced 1 | -0.0155451 |
| FLNB | filamin B, beta | -0.0155159 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.0154932 |
| ATP13A3 | ATPase type 13A3 | -0.0154515 |
| MYOF | myoferlin | -0.0153165 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0153088 |
| PHF20 | PHD finger protein 20 | -0.0152833 |
