| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tomivosertib perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tomivosertib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.156495 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.12161 |
| ENO1 | enolase 1, (alpha) | 0.112458 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.104453 |
| AREG | amphiregulin | 0.0909429 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.084791 |
| VMP1 | vacuole membrane protein 1 | 0.0832883 |
| NAV1 | neuron navigator 1 | 0.0790352 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0755815 |
| TPM4 | tropomyosin 4 | 0.0746042 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0744887 |
| THOC2 | THO complex 2 | 0.0743305 |
| GOLGB1 | golgin B1 | 0.0736264 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0727555 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0711712 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.071081 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0709335 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0686126 |
| DTNA | dystrobrevin, alpha | 0.0682298 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0682079 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0676222 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0674999 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0657918 |
| SSH2 | slingshot protein phosphatase 2 | 0.0632304 |
| BPTF | bromodomain PHD finger transcription factor | 0.0629866 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0623152 |
| RPL31 | ribosomal protein L31 | 0.0614394 |
| ATP13A3 | ATPase type 13A3 | 0.0603604 |
| SERINC5 | serine incorporator 5 | 0.0598868 |
| RNF145 | ring finger protein 145 | 0.0591683 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0582395 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0581911 |
| RBM39 | RNA binding motif protein 39 | 0.058059 |
| NBAS | neuroblastoma amplified sequence | 0.0568513 |
| OGA | O-GlcNAcase | 0.0561252 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0558953 |
| GOLGA4 | golgin A4 | 0.0557087 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0551265 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0540432 |
| FLNB | filamin B, beta | 0.0537261 |
| POTEF | POTE ankyrin domain family, member F | 0.0533183 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0530753 |
| IGF1R | insulin-like growth factor 1 receptor | 0.051789 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0515786 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0513079 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0505779 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0499385 |
| RUNX1 | runt-related transcription factor 1 | 0.049838 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0488879 |
| TPR | translocated promoter region, nuclear basket protein | 0.0483207 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0468408 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0462644 |
| MT2A | metallothionein 2A | 0.0462451 |
| NDRG1 | N-myc downstream regulated 1 | 0.0456939 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0446128 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.0445225 |
| VCL | vinculin | 0.0440602 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0436781 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0408839 |
| RPS8 | ribosomal protein S8 | 0.0402676 |
| ATXN1 | ataxin 1 | 0.0397965 |
| TMEM87A | transmembrane protein 87A | 0.0381975 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0376314 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0371629 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0352613 |
| SPAG9 | sperm associated antigen 9 | 0.0350334 |
| HELZ | helicase with zinc finger | 0.0345764 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0344101 |
| BRD2 | bromodomain containing 2 | 0.0342325 |
| B2M | beta-2-microglobulin | 0.0331937 |
| RPS6 | ribosomal protein S6 | 0.0323432 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0321691 |
| EFNA5 | ephrin-A5 | 0.03162 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0303804 |
| TENM3 | teneurin transmembrane protein 3 | 0.0285582 |
| FAM13A | family with sequence similarity 13, member A | 0.0279817 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0277101 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0267985 |
| ACTG1 | actin gamma 1 | 0.0261869 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0248 |
| NF1 | neurofibromin 1 | 0.0247166 |
| RPL26 | ribosomal protein L26 | 0.0236381 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0225284 |
| TOP1 | topoisomerase (DNA) I | 0.0216482 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0200413 |
| RPL37A | ribosomal protein L37a | 0.0197522 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0193947 |
| SLTM | SAFB-like, transcription modulator | 0.0186724 |
| RPL11 | ribosomal protein L11 | 0.017851 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0167291 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0154718 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0154004 |
| DST | dystonin | 0.0153397 |
| RPS12 | ribosomal protein S12 | 0.0145614 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0134571 |
| ZNF292 | zinc finger protein 292 | 0.0131965 |
| HMGA2 | high mobility group AT-hook 2 | 0.0128167 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.012028 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0116363 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0115669 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.32083 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.126772 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.11858 |
| EGFR | epidermal growth factor receptor | -0.107424 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.104227 |
| IGF2 | insulin-like growth factor 2 | -0.104046 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.103837 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0955304 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0943377 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0941154 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0838616 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0725149 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0703462 |
| PARD3 | par-3 family cell polarity regulator | -0.068957 |
| RIGI | RNA sensor RIG-I | -0.0672264 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0648264 |
| BBX | bobby sox homolog (Drosophila) | -0.0632775 |
| APP | amyloid beta (A4) precursor protein | -0.062589 |
| RORA | RAR-related orphan receptor A | -0.0622016 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0595955 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0594214 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.057711 |
| AOPEP | aminopeptidase O (putative) | -0.056051 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0553345 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0548939 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0544322 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0543323 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0527905 |
| CDH13 | cadherin 13 | -0.0524272 |
| GPC6 | glypican 6 | -0.0505956 |
| SMYD3 | SET and MYND domain containing 3 | -0.0459829 |
| RPL35A | ribosomal protein L35a | -0.0445533 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.043782 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0436099 |
| PDE10A | phosphodiesterase 10A | -0.0424072 |
| SETD5 | SET domain containing 5 | -0.0411881 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0396249 |
| ASPH | aspartate beta-hydroxylase | -0.0386647 |
| CTBP2 | C-terminal binding protein 2 | -0.0382459 |
| RAB10 | RAB10, member RAS oncogene family | -0.0370642 |
| MCL1 | myeloid cell leukemia 1 | -0.0369809 |
| MAP4 | microtubule-associated protein 4 | -0.0364122 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0362434 |
| SMAD3 | SMAD family member 3 | -0.0361342 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.034897 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.033998 |
| PTMA | prothymosin, alpha | -0.0336809 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0336167 |
| SQSTM1 | sequestosome 1 | -0.030637 |
| CANX | calnexin | -0.0292074 |
| TLK1 | tousled-like kinase 1 | -0.0286253 |
| ERBIN | erbb2 interacting protein | -0.0284941 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0281163 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0281116 |
| PGK1 | phosphoglycerate kinase 1 | -0.0279766 |
| TCF12 | transcription factor 12 | -0.0279593 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0275265 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0272346 |
| VIM | vimentin | -0.0268722 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0267323 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0258244 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.025679 |
| SRPK2 | SRSF protein kinase 2 | -0.0252471 |
| TXNRD1 | thioredoxin reductase 1 | -0.0246355 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0241037 |
| DOCK4 | dedicator of cytokinesis 4 | -0.023079 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0213472 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0211471 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0201425 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0188388 |
| PRKCA | protein kinase C, alpha | -0.0175084 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0168479 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0161861 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0157716 |
| ADIPOR2 | adiponectin receptor 2 | -0.0155199 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0150367 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0150361 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0150075 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | -0.0143202 |
| PKM | pyruvate kinase, muscle | -0.0142157 |
| FN1 | fibronectin 1 | -0.0137701 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0135501 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0132035 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0120635 |
| COPA | coatomer protein complex, subunit alpha | -0.0118396 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0117687 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0112235 |
| CERS6 | ceramide synthase 6 | -0.0103709 |
| CUL4A | cullin 4A | -0.00960001 |
| FMNL2 | formin-like 2 | -0.00915747 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.00908459 |
| NFIA | nuclear factor I/A | -0.00880146 |
| NBEAL1 | neurobeachin-like 1 | -0.00869432 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.00839903 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0079202 |
| EXOC6B | exocyst complex component 6B | -0.0078519 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.00767131 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.00750072 |
| RAD51B | RAD51 paralog B | -0.00719114 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.00645201 |
