| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tomivosertib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tomivosertib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HDAC9 | histone deacetylase 9 | 0.0252562 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0215773 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0178554 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0172309 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0163702 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0160379 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0155053 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0154362 |
| COL5A2 | collagen, type V, alpha 2 | 0.0128789 |
| FOXP2 | forkhead box P2 | 0.0128549 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0127696 |
| GPHN | gephyrin | 0.0125282 |
| RPS2 | ribosomal protein S2 | 0.0122859 |
| CDC73 | cell division cycle 73 | 0.0121585 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0120874 |
| USP53 | ubiquitin specific peptidase 53 | 0.0118041 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0114366 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0113994 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.0113988 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0108703 |
| JUN | jun proto-oncogene | 0.0105743 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0105666 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0104992 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.0102081 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0101279 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0101134 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0100276 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.00996237 |
| INTS6 | integrator complex subunit 6 | 0.00989552 |
| NOTCH2 | notch 2 | 0.00982774 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.00978097 |
| NCKAP1 | NCK-associated protein 1 | 0.00973514 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.00965879 |
| DENND4C | DENN/MADD domain containing 4C | 0.00965628 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.00942185 |
| BRD2 | bromodomain containing 2 | 0.00940664 |
| PCDH18 | protocadherin 18 | 0.00939478 |
| ZNF146 | zinc finger protein 146 | 0.00929904 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.00928115 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.00922281 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.00922218 |
| ZFP36 | ZFP36 ring finger protein | 0.00917003 |
| ASPH | aspartate beta-hydroxylase | 0.00912885 |
| HBP1 | HMG-box transcription factor 1 | 0.00909599 |
| SYDE2 | synapse defective 1, Rho GTPase, homolog 2 (C. elegans) | 0.00908966 |
| IWS1 | IWS1 homolog (S. cerevisiae) | 0.00899562 |
| RB1 | retinoblastoma 1 | 0.00872815 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0086851 |
| FNDC3A | fibronectin type III domain containing 3A | 0.00856446 |
| SUCO | SUN domain containing ossification factor | 0.00854937 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.00853486 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 0.00853013 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.00844979 |
| IFRD1 | interferon-related developmental regulator 1 | 0.00831505 |
| NKTR | natural killer cell triggering receptor | 0.00826253 |
| GOLGB1 | golgin B1 | 0.00822124 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.00820849 |
| BBX | bobby sox homolog (Drosophila) | 0.00818464 |
| RIGI | RNA sensor RIG-I | 0.00810416 |
| CGAS | cyclic GMP-AMP synthase | 0.00804176 |
| PDLIM5 | PDZ and LIM domain 5 | 0.00801711 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.00794827 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.00790626 |
| FMNL2 | formin-like 2 | 0.00788716 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.00787586 |
| PM20D1 | peptidase M20 domain containing 1 | 0.00785725 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.00781307 |
| SNAPC1 | small nuclear RNA activating complex, polypeptide 1, 43kDa | 0.00779718 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | 0.00778822 |
| ANO6 | anoctamin 6 | 0.00778087 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.00774007 |
| TMEM131 | transmembrane protein 131 | 0.0077069 |
| DNAJC10 | DnaJ (Hsp40) homolog, subfamily C, member 10 | 0.00769654 |
| RCOR3 | REST corepressor 3 | 0.00761561 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.00761109 |
| UBN2 | ubinuclein 2 | 0.00758283 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0075645 |
| RCOR1 | REST corepressor 1 | 0.00752609 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.00750731 |
| CCNYL1 | cyclin Y-like 1 | 0.00739623 |
| KPNA1 | karyopherin alpha 1 (importin alpha 5) | 0.00739552 |
| OGA | O-GlcNAcase | 0.00739448 |
| LMO7 | LIM domain 7 | 0.00739009 |
| RAD21 | RAD21 homolog (S. pombe) | 0.00734987 |
| SMAD4 | SMAD family member 4 | 0.00732845 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.00730316 |
| HSPA4L | heat shock 70kDa protein 4-like | 0.00728086 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.00719528 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.00718825 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.00717732 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.00710322 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.00707063 |
| SECISBP2L | SECIS binding protein 2-like | 0.00700783 |
| ERBIN | erbb2 interacting protein | 0.0069752 |
| SUZ12 | SUZ12 polycomb repressive complex 2 subunit | 0.00696847 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.00693157 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.00692177 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.00691637 |
| EFNA5 | ephrin-A5 | 0.00687207 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.00686231 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.132979 |
| TMSB10 | thymosin beta 10 | -0.1057 |
| PTMA | prothymosin, alpha | -0.0685591 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0527141 |
| RPS16 | ribosomal protein S16 | -0.051068 |
| COL11A1 | collagen, type XI, alpha 1 | -0.0475604 |
| CADM2 | cell adhesion molecule 2 | -0.0469169 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.043435 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0429685 |
| RPLP1 | ribosomal protein, large, P1 | -0.0389813 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0365463 |
| PFN1 | profilin 1 | -0.0364621 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0346176 |
| CENPF | centromere protein F, 350/400kDa | -0.0336007 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0324011 |
| RPL35A | ribosomal protein L35a | -0.032272 |
| HMGB1 | high mobility group box 1 | -0.0316475 |
| ACTG1 | actin gamma 1 | -0.0314319 |
| GPC3 | glypican 3 | -0.0304845 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0296747 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0293186 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0284971 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0281544 |
| RPL11 | ribosomal protein L11 | -0.0280017 |
| TMSB4X | thymosin beta 4, X-linked | -0.0257837 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0257707 |
| RPL23 | ribosomal protein L23 | -0.0256518 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0253422 |
| RPS19 | ribosomal protein S19 | -0.0250242 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0248424 |
| RAI1 | retinoic acid induced 1 | -0.024228 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0239435 |
| RPL5 | ribosomal protein L5 | -0.0238028 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0235231 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0230839 |
| ITGAV | integrin, alpha V | -0.0228563 |
| H3-3B | H3.3 histone B | -0.0226888 |
| CALR | calreticulin | -0.0225967 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0220998 |
| RPS21 | ribosomal protein S21 | -0.0219877 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0218269 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0215298 |
| RPS6 | ribosomal protein S6 | -0.0214458 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0212761 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.021261 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0212105 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.021183 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0209965 |
| RPS8 | ribosomal protein S8 | -0.0209084 |
| RPL32 | ribosomal protein L32 | -0.0208718 |
| THBS1 | thrombospondin 1 | -0.020611 |
| RTN4 | reticulon 4 | -0.0199781 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0199477 |
| S100A9 | S100 calcium binding protein A9 | -0.0198475 |
| RPLP2 | ribosomal protein, large, P2 | -0.0196631 |
| YBX1 | Y box binding protein 1 | -0.0195571 |
| TENM3 | teneurin transmembrane protein 3 | -0.0191346 |
| RPL19 | ribosomal protein L19 | -0.0189399 |
| COL1A2 | collagen, type I, alpha 2 | -0.0188018 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0185051 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0180376 |
| DEK | DEK proto-oncogene | -0.0177742 |
| S100A10 | S100 calcium binding protein A10 | -0.0177257 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0176478 |
| RPL36A | ribosomal protein L36a | -0.0176459 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0172706 |
| GNAS | GNAS complex locus | -0.0172138 |
| MAP4 | microtubule-associated protein 4 | -0.0171131 |
| RPL12 | ribosomal protein L12 | -0.016918 |
| RPL34 | ribosomal protein L34 | -0.0168364 |
| FBL | fibrillarin | -0.016714 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0164321 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0163127 |
| ACTN4 | actinin, alpha 4 | -0.0160766 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0157139 |
| PHIP | pleckstrin homology domain interacting protein | -0.0153992 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0152975 |
| NRG1 | neuregulin 1 | -0.0152775 |
| CALM3 | calmodulin 3 (phosphorylase kinase, delta) | -0.0152677 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0152315 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0151279 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0151165 |
| MKI67 | marker of proliferation Ki-67 | -0.0150023 |
| HMGB2 | high mobility group box 2 | -0.0149719 |
| AHNAK | AHNAK nucleoprotein | -0.0149642 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0146694 |
| RPL8 | ribosomal protein L8 | -0.0145989 |
| SERF2 | small EDRK-rich factor 2 | -0.0145114 |
| PCBP2 | poly(rC) binding protein 2 | -0.0143507 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0142609 |
| RPL21 | ribosomal protein L21 | -0.0142019 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.014168 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0138379 |
| RPL36 | ribosomal protein L36 | -0.0136604 |
| EMP1 | epithelial membrane protein 1 | -0.0136422 |
| PLPP1 | phospholipid phosphatase 1 | -0.0135517 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0135404 |
| EIF3K | eukaryotic translation initiation factor 3, subunit K | -0.0134797 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.013344 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0133091 |
