Tomivosertib_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tomivosertib perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tomivosertib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.163223
HDAC9 histone deacetylase 9 0.115923
VCAN versican 0.0902882
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0782164
RPS12 ribosomal protein S12 0.0750753
EEF2 eukaryotic translation elongation factor 2 0.0683196
ZFP36L1 ZFP36 ring finger protein-like 1 0.0663598
MT2A metallothionein 2A 0.066019
APLP2 amyloid beta (A4) precursor-like protein 2 0.060932
B2M beta-2-microglobulin 0.0606178
CD44 CD44 molecule (Indian blood group) 0.0569295
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.054542
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0513911
RPS6 ribosomal protein S6 0.0512219
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0499441
VMP1 vacuole membrane protein 1 0.0466788
RPS2 ribosomal protein S2 0.0430516
RPS3 ribosomal protein S3 0.0424704
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.039925
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0381407
SOX9 SRY (sex determining region Y)-box 9 0.0362306
BICC1 BicC family RNA binding protein 1 0.0345535
BIRC3 baculoviral IAP repeat containing 3 0.034339
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0339721
SYNJ2 synaptojanin 2 0.0323605
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0322824
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0316778
BRD2 bromodomain containing 2 0.0315573
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0310614
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0307387
RACK1 receptor for activated C kinase 1 0.0305143
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0303544
CREB5 cAMP responsive element binding protein 5 0.0302085
GPBP1 GC-rich promoter binding protein 1 0.0299792
RPL37A ribosomal protein L37a 0.0299143
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0296421
OPTN optineurin 0.0289748
IRAK2 interleukin-1 receptor-associated kinase 2 0.0282734
IGFBP7 insulin-like growth factor binding protein 7 0.0280439
AHR aryl hydrocarbon receptor 0.0280412
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0280114
SAMD9 sterile alpha motif domain containing 9 0.0277843
RPS8 ribosomal protein S8 0.0277631
NAP1L1 nucleosome assembly protein 1-like 1 0.0275459
POTEF POTE ankyrin domain family, member F 0.0274693
LDHA lactate dehydrogenase A 0.0272759
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0272515
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0264761
DSTN destrin (actin depolymerizing factor) 0.0264668
LIMA1 LIM domain and actin binding 1 0.0264299
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0261462
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0254337
GOLGB1 golgin B1 0.0252071
WEE1 WEE1 G2 checkpoint kinase 0.0248967
MBNL1 muscleblind-like splicing regulator 1 0.0247886
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0243048
RPL26 ribosomal protein L26 0.0238512
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0237489
MCFD2 multiple coagulation factor deficiency 2 0.0236244
KYNU kynureninase 0.0235502
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0235169
STC1 stanniocalcin 1 0.0233695
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.023091
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0230429
HLA-A major histocompatibility complex, class I, A 0.0228696
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.02273
SRGN serglycin 0.0226089
CXCL8 chemokine (C-X-C motif) ligand 8 0.0220891
ANKRD28 ankyrin repeat domain 28 0.021547
TLE4 transducin-like enhancer of split 4 0.0214663
SVIL supervillin 0.0213261
ZSWIM6 zinc finger, SWIM-type containing 6 0.0212703
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0206991
ZFP36 ZFP36 ring finger protein 0.0205966
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.020541
ALCAM activated leukocyte cell adhesion molecule 0.0205259
RPS17 ribosomal protein S17 0.0203757
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0203151
CENPF centromere protein F, 350/400kDa 0.020298
EEF1G eukaryotic translation elongation factor 1 gamma 0.0201311
FOS FBJ murine osteosarcoma viral oncogene homolog 0.020067
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0199201
SP100 SP100 nuclear antigen 0.0198117
SQSTM1 sequestosome 1 0.0195023
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0192706
GADD45B growth arrest and DNA-damage-inducible, beta 0.0192135
CBX3 chromobox homolog 3 0.0191449
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0188635
SMAD3 SMAD family member 3 0.0186945
BHLHE40 basic helix-loop-helix family, member e40 0.0185835
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 0.0184243
IFITM3 interferon induced transmembrane protein 3 0.0183462
JMJD1C jumonji domain containing 1C 0.0181444
AKAP9 A kinase (PRKA) anchor protein 9 0.0178522
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0177945
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0176605
LOC102724023 ES1 protein homolog, mitochondrial 0.0175979
SERINC1 serine incorporator 1 0.0174144
CRY1 cryptochrome circadian clock 1 0.0172647
MAST4 microtubule associated serine/threonine kinase family member 4 0.017217

decreased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial -0.246371
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.183657
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.128381
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.10672
IGFBP3 insulin-like growth factor binding protein 3 -0.0964481
FN1 fibronectin 1 -0.0943098
NAMPT nicotinamide phosphoribosyltransferase -0.0931249
PGK1 phosphoglycerate kinase 1 -0.0929834
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0860908
AHNAK AHNAK nucleoprotein -0.0819571
ELL2 elongation factor, RNA polymerase II, 2 -0.0809288
NDRG1 N-myc downstream regulated 1 -0.0797626
FRMD4A FERM domain containing 4A -0.0776438
CADM1 cell adhesion molecule 1 -0.0688498
ZMYND8 zinc finger, MYND-type containing 8 -0.0682222
TPT1 tumor protein, translationally-controlled 1 -0.0630738
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.063017
KDM3A lysine (K)-specific demethylase 3A -0.0599933
COL6A3 collagen, type VI, alpha 3 -0.0597476
IER3 immediate early response 3 -0.0593953
CANX calnexin -0.0588703
FNDC3B fibronectin type III domain containing 3B -0.0587838
WSB1 WD repeat and SOCS box containing 1 -0.0571445
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0570545
DIAPH2 diaphanous-related formin 2 -0.0553664
ZFAND3 zinc finger, AN1-type domain 3 -0.0549628
HLA-B major histocompatibility complex, class I, B -0.0535333
SMYD3 SET and MYND domain containing 3 -0.0527284
PTMA prothymosin, alpha -0.0524637
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0523623
PDE10A phosphodiesterase 10A -0.0496432
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0479807
MYH9 myosin, heavy chain 9, non-muscle -0.0474267
TMSB10 thymosin beta 10 -0.0462074
RBM39 RNA binding motif protein 39 -0.0450459
ACTG1 actin gamma 1 -0.0448184
AFF4 AF4/FMR2 family, member 4 -0.0444858
CTSD cathepsin D -0.0439218
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0439062
RAB1A RAB1A, member RAS oncogene family -0.0438812
CTSB cathepsin B -0.0430354
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0429704
VIM vimentin -0.0422317
FRMPD4 FERM and PDZ domain containing 4 -0.041938
AFF3 AF4/FMR2 family, member 3 -0.0416458
MAP4 microtubule-associated protein 4 -0.0406375
CALR calreticulin -0.0404576
IQGAP1 IQ motif containing GTPase activating protein 1 -0.039999
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0394293
LOX lysyl oxidase -0.0384074
GNAS GNAS complex locus -0.0380544
FOXO3 forkhead box O3 -0.0378013
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0376471
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0374445
MMP12 matrix metallopeptidase 12 -0.0364767
FTH1 ferritin, heavy polypeptide 1 -0.0364357
SDK1 sidekick cell adhesion molecule 1 -0.0357397
TNS3 tensin 3 -0.0355539
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0349501
BTG1 B-cell translocation gene 1, anti-proliferative -0.034845
WTAP Wilms tumor 1 associated protein -0.0347843
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0347781
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0346351
RPS24 ribosomal protein S24 -0.0338004
KPNB1 karyopherin (importin) beta 1 -0.0332263
ADAM12 ADAM metallopeptidase domain 12 -0.0329571
RTN4 reticulon 4 -0.0329392
WDR45B WD repeat domain 45B -0.0324263
FAM20C family with sequence similarity 20, member C -0.032221
HDLBP high density lipoprotein binding protein -0.0321155
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0318281
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.031809
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0318031
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0316851
PLIN2 perilipin 2 -0.031422
RAI14 retinoic acid induced 14 -0.0311956
THBS2 thrombospondin 2 -0.0306678
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0304295
NPEPPS aminopeptidase puromycin sensitive -0.0303524
DST dystonin -0.0299999
OGA O-GlcNAcase -0.0299879
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0294603
ANXA2 annexin A2 -0.0293445
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0291222
FBXO11 F-box protein 11 -0.0288601
NT5C2 5'-nucleotidase, cytosolic II -0.0285851
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0282388
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0281695
COL5A1 collagen, type V, alpha 1 -0.0279605
TUBB tubulin, beta class I -0.0279178
SDCBP syndecan binding protein (syntenin) -0.0279116
SBF2 SET binding factor 2 -0.0278715
DLG1 discs, large homolog 1 (Drosophila) -0.0278591
PPARD peroxisome proliferator-activated receptor delta -0.0277361
VCL vinculin -0.0276896
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0276494
SLC38A2 solute carrier family 38, member 2 -0.0271844
STAG2 stromal antigen 2 -0.0266965
ANKRD10 ankyrin repeat domain 10 -0.0265166
LOXL2 lysyl oxidase-like 2 -0.0263792