| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tomivosertib perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tomivosertib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0721264 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0609799 |
| ANXA1 | annexin A1 | 0.0540812 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0531572 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0490935 |
| RPL37A | ribosomal protein L37a | 0.0453812 |
| B2M | beta-2-microglobulin | 0.0452385 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0450359 |
| RNF145 | ring finger protein 145 | 0.041808 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0417049 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0412239 |
| RPL26 | ribosomal protein L26 | 0.0411998 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.0407049 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0399475 |
| TXNRD1 | thioredoxin reductase 1 | 0.0391903 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0389185 |
| ZFR | zinc finger RNA binding protein | 0.0387498 |
| VMP1 | vacuole membrane protein 1 | 0.0382568 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0381719 |
| SON | SON DNA binding protein | 0.0366082 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0362048 |
| RPL9 | ribosomal protein L9 | 0.0357812 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0355362 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0351911 |
| RBM25 | RNA binding motif protein 25 | 0.0346727 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0343151 |
| TPI1 | triosephosphate isomerase 1 | 0.033469 |
| SET | SET nuclear proto-oncogene | 0.0320488 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0315987 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0312049 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0304825 |
| CDK6 | cyclin-dependent kinase 6 | 0.0298525 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0298153 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0297874 |
| RPS17 | ribosomal protein S17 | 0.0297863 |
| SQSTM1 | sequestosome 1 | 0.0295694 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0289003 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0288146 |
| RPS12 | ribosomal protein S12 | 0.0288017 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.028158 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0281005 |
| TPR | translocated promoter region, nuclear basket protein | 0.0280624 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.02794 |
| RPS14 | ribosomal protein S14 | 0.0273141 |
| TASOR2 | transcription activation suppressor family member 2 | 0.0272209 |
| RPS2 | ribosomal protein S2 | 0.0271806 |
| SIK3 | SIK family kinase 3 | 0.0271189 |
| ANGPTL4 | angiopoietin-like 4 | 0.0259522 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.0259344 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0256763 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0256713 |
| GOLGA4 | golgin A4 | 0.0255086 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0250919 |
| SNRPB2 | small nuclear ribonucleoprotein polypeptide B | 0.0250074 |
| PPIL4 | peptidylprolyl isomerase (cyclophilin)-like 4 | 0.0249942 |
| USP47 | ubiquitin specific peptidase 47 | 0.0249896 |
| DENND4A | DENN/MADD domain containing 4A | 0.0248876 |
| DDX18 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | 0.024804 |
| PITPNB | phosphatidylinositol transfer protein, beta | 0.0247637 |
| WBP11 | WW domain binding protein 11 | 0.0246799 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | 0.024376 |
| RPS3 | ribosomal protein S3 | 0.0242873 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0242301 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0241451 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0239264 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0238816 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0234082 |
| KIF5B | kinesin family member 5B | 0.0232413 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | 0.0231935 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0231643 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0226729 |
| YY1 | YY1 transcription factor | 0.0226184 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0226136 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0225467 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0225422 |
| NSD1 | nuclear receptor binding SET domain protein 1 | 0.0224091 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0223214 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0220159 |
| CUL5 | cullin 5 | 0.0217839 |
| PRPF4B | pre-mRNA processing factor 4B | 0.0217506 |
| WWOX | WW domain containing oxidoreductase | 0.0216994 |
| CHKA | choline kinase alpha | 0.0216815 |
| NOL10 | nucleolar protein 10 | 0.0215288 |
| TOP1 | topoisomerase (DNA) I | 0.0214796 |
| CKAP2 | cytoskeleton associated protein 2 | 0.0213649 |
| TJP1 | tight junction protein 1 | 0.020999 |
| TGOLN2 | trans-golgi network protein 2 | 0.0209682 |
| LRRC58 | leucine rich repeat containing 58 | 0.0209566 |
| PLEKHM3 | pleckstrin homology domain containing, family M, member 3 | 0.0209375 |
| TMEM245 | transmembrane protein 245 | 0.0208278 |
| LARP4 | La ribonucleoprotein domain family, member 4 | 0.0208229 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0207673 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.020657 |
| AHI1 | Abelson helper integration site 1 | 0.0204807 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0204664 |
| GPHN | gephyrin | 0.0204621 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0204607 |
| SFSWAP | splicing factor, suppressor of white-apricot family | 0.0204208 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0203149 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.02031 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.133603 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.132698 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.120738 |
| AHNAK | AHNAK nucleoprotein | -0.114127 |
| HMGA2 | high mobility group AT-hook 2 | -0.102295 |
| SDC4 | syndecan 4 | -0.0955418 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0940508 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.088849 |
| PTMA | prothymosin, alpha | -0.0839191 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0754608 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.06916 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0690241 |
| NDRG1 | N-myc downstream regulated 1 | -0.0663343 |
| ATXN1 | ataxin 1 | -0.0661289 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0626421 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0615073 |
| ANXA2 | annexin A2 | -0.059437 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0582324 |
| ACTG1 | actin gamma 1 | -0.0575277 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0563965 |
| SPAG9 | sperm associated antigen 9 | -0.0534202 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0514517 |
| RAI14 | retinoic acid induced 14 | -0.0511824 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0507151 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0485273 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0479939 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.047818 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0473486 |
| TPM4 | tropomyosin 4 | -0.0461288 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0460614 |
| PRELID2 | PRELI domain containing 2 | -0.0456065 |
| OSMR | oncostatin M receptor | -0.0454115 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0442438 |
| CAPRIN2 | caprin family member 2 | -0.0430522 |
| MCL1 | myeloid cell leukemia 1 | -0.0428748 |
| FBXO11 | F-box protein 11 | -0.0428318 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0427344 |
| PYGL | phosphorylase, glycogen, liver | -0.0419886 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0411385 |
| LDHA | lactate dehydrogenase A | -0.0407091 |
| CANX | calnexin | -0.0406273 |
| FMN1 | formin 1 | -0.0401402 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0398238 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0396143 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0395059 |
| PRKCA | protein kinase C, alpha | -0.0393137 |
| TMEM123 | transmembrane protein 123 | -0.0385015 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0379681 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.037778 |
| FLNB | filamin B, beta | -0.0376111 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0373895 |
| TAOK1 | TAO kinase 1 | -0.0371508 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0369959 |
| COL5A1 | collagen, type V, alpha 1 | -0.0367783 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0367659 |
| PGK1 | phosphoglycerate kinase 1 | -0.0363345 |
| LMO7 | LIM domain 7 | -0.0361647 |
| FLNA | filamin A, alpha | -0.0357618 |
| ACTN1 | actinin, alpha 1 | -0.0353744 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0348451 |
| ARFGEF3 | ARFGEF family member 3 | -0.0346919 |
| PKM | pyruvate kinase, muscle | -0.034576 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0344777 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0340866 |
| APP | amyloid beta (A4) precursor protein | -0.0338107 |
| SETD5 | SET domain containing 5 | -0.03351 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0334456 |
| NF1 | neurofibromin 1 | -0.0334339 |
| PODXL | podocalyxin-like | -0.0330418 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0328864 |
| ZNF292 | zinc finger protein 292 | -0.0328128 |
| RNF130 | ring finger protein 130 | -0.0327811 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0323917 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0322783 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.032273 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0320418 |
| RNF213 | ring finger protein 213 | -0.0319211 |
| DNER | delta/notch-like EGF repeat containing | -0.0316944 |
| VIM | vimentin | -0.0316679 |
| RORA | RAR-related orphan receptor A | -0.0316484 |
| CALU | calumenin | -0.0314789 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0313969 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | -0.0313776 |
| PARD3 | par-3 family cell polarity regulator | -0.0313622 |
| RANBP17 | RAN binding protein 17 | -0.0312741 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0312359 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0311434 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0310962 |
| GPC6 | glypican 6 | -0.0307842 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0307522 |
| PTK2 | protein tyrosine kinase 2 | -0.0305463 |
| ZNF609 | zinc finger protein 609 | -0.0305014 |
| MEF2A | myocyte enhancer factor 2A | -0.0304036 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0303138 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0298842 |
| MAP1B | microtubule-associated protein 1B | -0.0298785 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0296279 |
| TMSB10 | thymosin beta 10 | -0.0295815 |
| NUP58 | nucleoporin 58 | -0.0293844 |
| LAMB1 | laminin, beta 1 | -0.0293834 |
