Tonsillitis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur. (Human Disease Ontology, DOID_10456)
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Genes

230 genes co-occuring with the disease Tonsillitis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
CRP C-reactive protein, pentraxin-related 2.636
CD4 CD4 molecule 2.294
TNF tumor necrosis factor 2.251
MYOM2 myomesin 2 2.245
IL6 interleukin 6 2.235
IFNG interferon, gamma 2.192
IL1B interleukin 1, beta 2.168
CD8A CD8a molecule 2.126
CXCL8 chemokine (C-X-C motif) ligand 8 2.005
IL10 interleukin 10 1.982
CD19 CD19 molecule 1.981
IL4 interleukin 4 1.971
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.947
ALB albumin 1.945
IL2 interleukin 2 1.929
IL17A interleukin 17A 1.905
C1GALT1C1 C1GALT1-specific chaperone 1 1.863
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 1.858
JCHAIN joining chain of multimeric IgA and IgM 1.852
HORMAD2 HORMA domain containing 2 1.851
IL1A interleukin 1, alpha 1.819
TLR4 toll-like receptor 4 1.736
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 1.735
MEFV Mediterranean fever 1.732
CR2 complement component (3d/Epstein Barr virus) receptor 2 1.71
NCAM1 neural cell adhesion molecule 1 1.672
DEFB1 defensin, beta 1 1.641
CD38 CD38 molecule 1.636
TLR9 toll-like receptor 9 1.631
IL5 interleukin 5 1.629
CD27 CD27 molecule 1.615
PIGR polymeric immunoglobulin receptor 1.607
C3 complement component 3 1.593
CAMP cathelicidin antimicrobial peptide 1.578
CD40LG CD40 ligand 1.571
ACE angiotensin I converting enzyme 1.569
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 1.565
IFNA1 interferon, alpha 1 1.557
CD68 CD68 molecule 1.547
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.546
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.544
MVK mevalonate kinase 1.543
DEFB4A defensin, beta 4A 1.539
F2 coagulation factor II (thrombin) 1.534
MPO myeloperoxidase 1.531
TGFB1 transforming growth factor, beta 1 1.528
CXCR5 chemokine (C-X-C motif) receptor 5 1.523
TLR2 toll-like receptor 2 1.521
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 1.511
CSF3 colony stimulating factor 3 (granulocyte) 1.506
CD40 CD40 molecule, TNF receptor superfamily member 5 1.503
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.495
PTPRC protein tyrosine phosphatase, receptor type, C 1.493
IL13 interleukin 13 1.493
HLA-C major histocompatibility complex, class I, C 1.493
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 1.485
NLRP3 NLR family, pyrin domain containing 3 1.476
DEFB112 defensin, beta 112 1.476
FOXP3 forkhead box P3 1.472
ERVW-1 endogenous retrovirus group W, member 1 1.472
BCL6 B-cell CLL/lymphoma 6 1.47
KSR1 kinase suppressor of ras 1 1.467
LTF lactotransferrin 1.466
PLG plasminogen 1.463
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.462
F3 coagulation factor III (thromboplastin, tissue factor) 1.457
FCAR Fc fragment of IgA receptor 1.449
PXDNL peroxidasin-like 1.449
PXDN peroxidasin 1.448
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 1.435
IFNB1 interferon, beta 1, fibroblast 1.419
ACE2 angiotensin I converting enzyme 2 1.416
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.412
ERV3-1 endogenous retrovirus group 3, member 1 1.409
ERVFRD-1 endogenous retrovirus group FRD, member 1 1.408
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.406
INS insulin 1.401
IL18 interleukin 18 1.398
IL22 interleukin 22 1.396
LTA lymphotoxin alpha 1.393
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 1.393
IL36RN interleukin 36 receptor antagonist 1.391
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 1.389
BCL2 B-cell CLL/lymphoma 2 1.389
AICDA activation-induced cytidine deaminase 1.388
TLR7 toll-like receptor 7 1.387
PGPEP1 pyroglutamyl-peptidase I 1.38
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.363
CCL2 chemokine (C-C motif) ligand 2 1.362
CD5 CD5 molecule 1.354
IL17F interleukin 17F 1.353
CD83 CD83 molecule 1.342
FN1 fibronectin 1 1.34
SPEG SPEG complex locus 1.338
REN renin 1.338
DEFB113 defensin, beta 113 1.333
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.31
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.305
CD69 CD69 molecule 1.304
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.302
IL36R interleukin 36 receptor 1.301
CARD14 caspase recruitment domain family, member 14 1.295
TLR3 toll-like receptor 3 1.295
MME membrane metallo-endopeptidase 1.295
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 1.295
MYD88 myeloid differentiation primary response 88 1.292
ICAM1 intercellular adhesion molecule 1 1.291
CXCL10 chemokine (C-X-C motif) ligand 10 1.29
ICOS inducible T-cell co-stimulator 1.289
DNPEP aspartyl aminopeptidase 1.288
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.285
LOC102723407 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 1.279
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.276
NLRP12 NLR family, pyrin domain containing 12 1.274
C4A complement component 4A (Rodgers blood group) 1.273
ALPK1 alpha-kinase 1 1.272
KNG1 kininogen 1 1.271
CD28 CD28 molecule 1.271
INSM2 insulinoma-associated 2 1.27
CCR7 chemokine (C-C motif) receptor 7 1.27
ACTB actin, beta 1.263
ZSCAN22 zinc finger and SCAN domain containing 22 1.258
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.256
JUN jun proto-oncogene 1.249
CD1C CD1c molecule 1.248
TBX21 T-box 21 1.246
MTM1 myotubularin 1 1.225
PRF1 perforin 1 (pore forming protein) 1.223
ELANE elastase, neutrophil expressed 1.222
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.222
CD79A CD79a molecule, immunoglobulin-associated alpha 1.218
CDKN2A cyclin-dependent kinase inhibitor 2A 1.213
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 1.21
CFP complement factor properdin 1.209
CD80 CD80 molecule 1.208
MBL2 mannose-binding lectin (protein C) 2, soluble 1.207
HLA-B major histocompatibility complex, class I, B 1.204
CCR6 chemokine (C-C motif) receptor 6 1.197
IL7R interleukin 7 receptor 1.191
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.185
TP53 tumor protein p53 1.185
PRTN3 proteinase 3 1.184
CD86 CD86 molecule 1.183
CCRL2 chemokine (C-C motif) receptor-like 2 1.178
IL37 interleukin 37 1.178
CD34 CD34 molecule 1.175
SDC1 syndecan 1 1.172
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.167
GPX2 glutathione peroxidase 2 1.161
ACHE acetylcholinesterase (Yt blood group) 1.161
IL7 interleukin 7 1.16
CCL20 chemokine (C-C motif) ligand 20 1.16
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.159
SELL selectin L 1.159
RNPEP arginyl aminopeptidase (aminopeptidase B) 1.153
CKM creatine kinase, muscle 1.153
HP haptoglobin 1.15
TAC1 tachykinin, precursor 1 1.147
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.147
CKMT1B creatine kinase, mitochondrial 1B 1.146
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 1.145
POM121 POM121 transmembrane nucleoporin 1.144
CXCR4 chemokine (C-X-C motif) receptor 4 1.143
CKB creatine kinase, brain 1.143
CCL5 chemokine (C-C motif) ligand 5 1.142
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.142
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.13
C4B complement component 4B (Chido blood group) 1.128
GPX3 glutathione peroxidase 3 1.127
AZU1 azurocidin 1 1.126
GPX6 glutathione peroxidase 6 1.124
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 1.124
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 1.124
GPX5 glutathione peroxidase 5 1.123
GPX8 glutathione peroxidase 8 (putative) 1.122
GPX7 glutathione peroxidase 7 1.119
IFNA2 interferon, alpha 2 1.115
DEFB103A defensin, beta 103A 1.115
SI sucrase-isomaltase (alpha-glucosidase) 1.112
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.112
IFNA17 interferon, alpha 17 1.106
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 1.105
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.105
CCL27 chemokine (C-C motif) ligand 27 1.103
MGAM maltase-glucoamylase 1.102
C1S complement component 1, s subcomponent 1.095
CD2 CD2 molecule 1.092
DEFB4B defensin, beta 4B 1.091
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.091
TFRC transferrin receptor 1.09
B3GAT1 beta-1,3-glucuronyltransferase 1 1.082
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.078
CXCL6 chemokine (C-X-C motif) ligand 6 1.075
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.071
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.069
POU2AF1 POU class 2 associating factor 1 1.063
PDLIM7 PDZ and LIM domain 7 (enigma) 1.062
NELFCD negative elongation factor complex member C/D 1.062
PAX5 paired box 5 1.06
S100A7 S100 calcium binding protein A7 1.06
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.054
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.053
CX3CL1 chemokine (C-X3-C motif) ligand 1 1.052
CXCL13 chemokine (C-X-C motif) ligand 13 1.052
RIPOR1 RHO family interacting cell polarization regulator 1 1.05
CX3CR1 chemokine (C-X3-C motif) receptor 1 1.048
IL23A interleukin 23, alpha subunit p19 1.048
IRAK4 interleukin-1 receptor-associated kinase 4 1.045
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 1.041
HAX1 HCLS1 associated protein X-1 1.041
ENPEP glutamyl aminopeptidase (aminopeptidase A) 1.037
ORM1 orosomucoid 1 1.035
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.034
IL15 interleukin 15 1.034
TLR1 toll-like receptor 1 1.03
ACKR2 atypical chemokine receptor 2 1.029
MEST mesoderm specific transcript 1.025
PRDM1 PR domain containing 1, with ZNF domain 1.022
CARD9 caspase recruitment domain family, member 9 1.019
PECAM1 platelet/endothelial cell adhesion molecule 1 1.017
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 1.011
ENAM enamelin 1.009
HMOX1 heme oxygenase 1 1.009
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.009
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 1.009
IL33 interleukin 33 1.007
BAX BCL2-associated X protein 1.005
CXCR3 chemokine (C-X-C motif) receptor 3 1.003
PSEN2 presenilin 2 1.002
AMBN ameloblastin (enamel matrix protein) 1.001