Tonsillitis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur. (Human Disease Ontology, DOID_10456)
External Link https://www.disgenet.org/browser/0/1/0/C0040425
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Genes

44 genes associated with the disease Tonsillitis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
AICDA activation-induced cytidine deaminase
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
BCL2 B-cell CLL/lymphoma 2
CCL20 chemokine (C-C motif) ligand 20
CCL24 chemokine (C-C motif) ligand 24
CCL27 chemokine (C-C motif) ligand 27
CCNB1 cyclin B1
CDKN2A cyclin-dependent kinase inhibitor 2A
CXCL8 chemokine (C-X-C motif) ligand 8
DEFB1 defensin, beta 1
EGFR epidermal growth factor receptor
FANCD2 Fanconi anemia, complementation group D2
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FDCSP follicular dendritic cell secreted protein
GALNS galactosamine (N-acetyl)-6-sulfatase
GAST gastrin
GEM GTP binding protein overexpressed in skeletal muscle
GPX1 glutathione peroxidase 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
IFNG interferon, gamma
IL10 interleukin 10
IL1B interleukin 1, beta
IL6 interleukin 6
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
LTA lymphotoxin alpha
LTF lactotransferrin
MBL2 mannose-binding lectin (protein C) 2, soluble
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
PAGR1 PAXIP1 associated glutamate-rich protein 1
PDLIM7 PDZ and LIM domain 7 (enigma)
PRCP prolylcarboxypeptidase (angiotensinase C)
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RXRB retinoid X receptor, beta
S100A7 S100 calcium binding protein A7
SKP1 S-phase kinase-associated protein 1
SOD2 superoxide dismutase 2, mitochondrial
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor