| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A hexose derivative that is 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose in which the hydroxy group has been converted to the corresponding sulfamate ester. It blocks voltage-dependent sodium channels and is used as an antiepileptic and for the prevention of migraine. (Chemical Entities of Biological Interest Ontology, CHEBI_63631) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5284627 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Topiramate relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SBSN | suprabasin | 1.6 |
| PIP | prolactin-induced protein | 1.4 |
| YAE1 | YAE1 maturation factor of ABCE1 | 0.89 |
| SPPL3 | signal peptide peptidase like 3 | 0.52 |
| SNX33 | sorting nexin 33 | 0.51 |
| ZSCAN29 | zinc finger and SCAN domain containing 29 | 0.41 |
| STK40 | serine/threonine kinase 40 | 0.4 |
| BSN | bassoon presynaptic cytomatrix protein | 0.38 |
| RCAN1 | regulator of calcineurin 1 | 0.38 |
| CNTRL | centriolin | 0.34 |
| SOX12 | SRY (sex determining region Y)-box 12 | 0.33 |
| PTK6 | protein tyrosine kinase 6 | 0.32 |
| INO80D | INO80 complex subunit D | 0.32 |
| CLCN6 | chloride channel, voltage-sensitive 6 | 0.32 |
| FAM126B | family with sequence similarity 126, member B | 0.32 |
| ZNF823 | zinc finger protein 823 | 0.32 |
| FBXW2 | F-box and WD repeat domain containing 2 | 0.31 |
| FMNL3 | formin-like 3 | 0.31 |
| FAM210B | family with sequence similarity 210, member B | 0.31 |
| ZXDB | zinc finger, X-linked, duplicated B | 0.3 |
| TRIM68 | tripartite motif containing 68 | 0.3 |
| ZNF749 | zinc finger protein 749 | 0.29 |
| RCBTB1 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 | 0.27 |
| STYX | serine/threonine/tyrosine interacting protein | 0.27 |
| SMTN | smoothelin | 0.27 |
| APBB1 | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | 0.26 |
| RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing | 0.26 |
| UNC5B | unc-5 homolog B (C. elegans) | 0.26 |
| SGCE | sarcoglycan, epsilon | 0.26 |
| FBXL15 | F-box and leucine-rich repeat protein 15 | 0.25 |
| TOMM40L | translocase of outer mitochondrial membrane 40 homolog (yeast)-like | 0.25 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.25 |
| FAM120C | family with sequence similarity 120C | 0.25 |
| KCTD20 | potassium channel tetramerization domain containing 20 | 0.25 |
| TNNI3K | TNNI3 interacting kinase | 0.25 |
| ENOX2 | ecto-NOX disulfide-thiol exchanger 2 | 0.25 |
| KLF3 | Kruppel-like factor 3 (basic) | 0.25 |
| PDIK1L | PDLIM1 interacting kinase 1 like | 0.25 |
| ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif, 7 | 0.24 |
| DDN | dendrin | 0.24 |
| B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | 0.24 |
| TRIM9 | tripartite motif containing 9 | 0.24 |
| BMP8A | bone morphogenetic protein 8a | 0.24 |
| ZNF14 | zinc finger protein 14 | 0.24 |
| ZDHHC23 | zinc finger, DHHC-type containing 23 | 0.23 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | 0.23 |
| MFSD8 | major facilitator superfamily domain containing 8 | 0.23 |
| BLOC1S2 | biogenesis of lysosomal organelles complex-1, subunit 2 | 0.23 |
| ACTL8 | actin-like 8 | 0.22 |
| PHF1 | PHD finger protein 1 | 0.22 |
| LYST | lysosomal trafficking regulator | 0.22 |
| ZBTB45 | zinc finger and BTB domain containing 45 | 0.22 |
| CCDC57 | coiled-coil domain containing 57 | 0.22 |
| CDC42SE2 | CDC42 small effector 2 | 0.22 |
| RNF13 | ring finger protein 13 | 0.22 |
| TMEM177 | transmembrane protein 177 | 0.21 |
| TIGD5 | tigger transposable element derived 5 | 0.21 |
| KCTD18 | potassium channel tetramerization domain containing 18 | 0.21 |
| MKRN4P | makorin ring finger protein 4, pseudogene | 0.21 |
| CCAR2 | cell cycle and apoptosis regulator 2 | 0.21 |
| RMND5B | required for meiotic nuclear division 5 homolog B (S. cerevisiae) | 0.21 |
| ZBTB46 | zinc finger and BTB domain containing 46 | 0.2 |
| TRIM39 | tripartite motif containing 39 | 0.2 |
| FN1 | fibronectin 1 | 0.2 |
| EHF | ets homologous factor | 0.2 |
| GALNT11 | polypeptide N-acetylgalactosaminyltransferase 11 | 0.2 |
| ZBTB8A | zinc finger and BTB domain containing 8A | 0.2 |
| C6ORF132 | chromosome 6 open reading frame 132 | 0.2 |
| CMC4 | C-x(9)-C motif containing 4 | 0.2 |
| C12ORF60 | chromosome 12 open reading frame 60 | 0.19 |
| TRDMT1 | tRNA aspartic acid methyltransferase 1 | 0.19 |
| SVIP | small VCP/p97-interacting protein | 0.19 |
| NBEAL1 | neurobeachin-like 1 | 0.19 |
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | 0.19 |
| DCLK2 | doublecortin-like kinase 2 | 0.19 |
| OTUB2 | OTU deubiquitinase, ubiquitin aldehyde binding 2 | 0.19 |
| ATXN2 | ataxin 2 | 0.19 |
| RPGR | retinitis pigmentosa GTPase regulator | 0.19 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | 0.19 |
| GPANK1 | G patch domain and ankyrin repeats 1 | 0.19 |
| KHNYN | KH and NYN domain containing | 0.19 |
| IL10RB | interleukin 10 receptor, beta | 0.19 |
| TIGD1 | tigger transposable element derived 1 | 0.18 |
| DUSP5 | dual specificity phosphatase 5 | 0.18 |
| GLRX2 | glutaredoxin 2 | 0.18 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.18 |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 | 0.18 |
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | 0.18 |
| PLEKHA7 | pleckstrin homology domain containing, family A member 7 | 0.18 |
| BRMS1L | breast cancer metastasis-suppressor 1-like | 0.18 |
| ERMARD | ER membrane-associated RNA degradation | 0.18 |
| SLC35B1 | solute carrier family 35, member B1 | 0.18 |
| JAG2 | jagged 2 | 0.18 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.18 |
| LANCL3 | LanC lantibiotic synthetase component C-like 3 (bacterial) | 0.18 |
| ENKD1 | enkurin domain containing 1 | 0.18 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.18 |
| SPICE1 | spindle and centriole associated protein 1 | 0.18 |
| PDGFRL | platelet-derived growth factor receptor-like | 0.18 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.18 |
| Symbol | Name | Standardized Value |
|---|---|---|
| POF1B | premature ovarian failure, 1B | -1.24 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -1.07 |
| TEN1 | TEN1 CST complex subunit | -0.73 |
| RHBDF1 | rhomboid 5 homolog 1 (Drosophila) | -0.68 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | -0.68 |
| DNAJB5 | DnaJ (Hsp40) homolog, subfamily B, member 5 | -0.54 |
| TREX1 | three prime repair exonuclease 1 | -0.54 |
| ERICH5 | glutamate-rich 5 | -0.51 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.51 |
| CCDC150 | coiled-coil domain containing 150 | -0.49 |
| RPLP1 | ribosomal protein, large, P1 | -0.47 |
| FAM219B | family with sequence similarity 219, member B | -0.47 |
| WHAMM | WAS protein homolog associated with actin, golgi membranes and microtubules | -0.46 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | -0.45 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -0.45 |
| DYRK2 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 | -0.45 |
| BCO2 | beta-carotene oxygenase 2 | -0.42 |
| MISO1 | mitochondrial inner membrane subdomain organizer 1 | -0.42 |
| SZT2 | seizure threshold 2 homolog (mouse) | -0.41 |
| CHMP1B | charged multivesicular body protein 1B | -0.4 |
| CYB5D2 | cytochrome b5 domain containing 2 | -0.39 |
| BRF2 | BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit | -0.39 |
| ZNF503 | zinc finger protein 503 | -0.39 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.39 |
| ERCC6 | excision repair cross-complementation group 6 | -0.39 |
| ZBTB4 | zinc finger and BTB domain containing 4 | -0.38 |
| NUP62 | nucleoporin 62kDa | -0.38 |
| FAT2 | FAT atypical cadherin 2 | -0.36 |
| BLOC1S4 | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino | -0.36 |
| NENF | neudesin neurotrophic factor | -0.35 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | -0.35 |
| OSER1 | oxidative stress responsive serine-rich 1 | -0.35 |
| TRIM29 | tripartite motif containing 29 | -0.35 |
| ATP6V0D1 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 | -0.35 |
| SLC25A46 | solute carrier family 25, member 46 | -0.34 |
| PTPDC1 | protein tyrosine phosphatase domain containing 1 | -0.34 |
| FTL | ferritin, light polypeptide | -0.33 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | -0.32 |
| REX1BD | required for excision 1-B domain containing | -0.32 |
| PFDN4 | prefoldin subunit 4 | -0.32 |
| DNAAF2 | dynein, axonemal, assembly factor 2 | -0.32 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -0.32 |
| CBY1 | chibby homolog 1 (Drosophila) | -0.32 |
| HOXA10 | homeobox A10 | -0.31 |
| COPZ1 | coatomer protein complex, subunit zeta 1 | -0.31 |
| F8 | coagulation factor VIII, procoagulant component | -0.3 |
| PMF1 | polyamine-modulated factor 1 | -0.3 |
| SPIDR | scaffolding protein involved in DNA repair | -0.3 |
| BORA | bora, aurora kinase A activator | -0.3 |
| CPTP | ceramide-1-phosphate transfer protein | -0.3 |
| BRK1 | BRICK1, SCAR/WAVE actin-nucleating complex subunit | -0.3 |
| ENO1 | enolase 1, (alpha) | -0.3 |
| B2M | beta-2-microglobulin | -0.3 |
| CYBRD1 | cytochrome b reductase 1 | -0.3 |
| SPATA2L | spermatogenesis associated 2-like | -0.3 |
| MYRF | myelin regulatory factor | -0.29 |
| ZNF576 | zinc finger protein 576 | -0.29 |
| KCNAB2 | potassium channel, voltage gated subfamily A regulatory beta subunit 2 | -0.29 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.29 |
| S100A14 | S100 calcium binding protein A14 | -0.29 |
| EGR1 | early growth response 1 | -0.29 |
| C19ORF54 | chromosome 19 open reading frame 54 | -0.29 |
| COQ9 | coenzyme Q9 | -0.29 |
| RAB30 | RAB30, member RAS oncogene family | -0.29 |
| DTD2 | D-tyrosyl-tRNA deacylase 2 (putative) | -0.29 |
| BOLA1 | bolA family member 1 | -0.28 |
| CSTF2 | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa | -0.28 |
| CHRD | chordin | -0.27 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.27 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.27 |
| TRIAP1 | TP53 regulated inhibitor of apoptosis 1 | -0.27 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.27 |
| C12ORF57 | chromosome 12 open reading frame 57 | -0.27 |
| WDR60 | WD repeat domain 60 | -0.27 |
| LYPLA2 | lysophospholipase II | -0.27 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.27 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | -0.27 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.27 |
| STMN2 | stathmin 2 | -0.26 |
| PLCB4 | phospholipase C, beta 4 | -0.26 |
| MYCBP | MYC binding protein | -0.26 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.26 |
| PLEKHG6 | pleckstrin homology domain containing, family G (with RhoGef domain) member 6 | -0.26 |
| TRO | trophinin | -0.26 |
| TCEA2 | transcription elongation factor A (SII), 2 | -0.26 |
| TECPR1 | tectonin beta-propeller repeat containing 1 | -0.26 |
| KCTD2 | potassium channel tetramerization domain containing 2 | -0.26 |
| TYMP | thymidine phosphorylase | -0.26 |
| S100A2 | S100 calcium binding protein A2 | -0.26 |
| ECI1 | enoyl-CoA delta isomerase 1 | -0.25 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | -0.25 |
| ZNF100 | zinc finger protein 100 | -0.25 |
| PEX19 | peroxisomal biogenesis factor 19 | -0.25 |
| DDT | D-dopachrome tautomerase | -0.25 |
| CIAO2B | cytosolic iron-sulfur assembly component 2B | -0.24 |
| PLPP6 | phospholipid phosphatase 6 | -0.24 |
| RNASEH2C | ribonuclease H2, subunit C | -0.24 |
| COPS4 | COP9 signalosome subunit 4 | -0.24 |
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | -0.24 |
| MICOS10 | mitochondrial contact site and cristae organizing system subunit 10 | -0.24 |
