| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Topotecan (hydrochloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.147882 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.12976 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.112914 |
| CDH13 | cadherin 13 | 0.102085 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0981739 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0962685 |
| OGA | O-GlcNAcase | 0.0801771 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0784914 |
| PTMA | prothymosin, alpha | 0.0774302 |
| FLNB | filamin B, beta | 0.0735452 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0677229 |
| SETD5 | SET domain containing 5 | 0.0659859 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0644558 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0630443 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0612303 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.060868 |
| ATP13A3 | ATPase type 13A3 | 0.0604301 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.05841 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0561646 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0557768 |
| MMP12 | matrix metallopeptidase 12 | 0.055355 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0551381 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0540731 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0499803 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0484389 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0478862 |
| GOLGA4 | golgin A4 | 0.0466297 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0465352 |
| TMSB4X | thymosin beta 4, X-linked | 0.0463922 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0451605 |
| CALR | calreticulin | 0.0449052 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0448095 |
| MSI2 | musashi RNA-binding protein 2 | 0.0447399 |
| NAV2 | neuron navigator 2 | 0.0446137 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0422174 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0415757 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0415584 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0402901 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0399293 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0398854 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.039729 |
| FMNL2 | formin-like 2 | 0.0392534 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0389472 |
| CD109 | CD109 molecule | 0.0383746 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0378342 |
| C1D | C1D nuclear receptor corepressor | 0.0376214 |
| HELZ | helicase with zinc finger | 0.0366701 |
| FN1 | fibronectin 1 | 0.0363067 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0361886 |
| FNIP1 | folliculin interacting protein 1 | 0.035665 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0354259 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0352482 |
| DENND5A | DENN/MADD domain containing 5A | 0.0347131 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0345929 |
| LMNA | lamin A/C | 0.0345618 |
| DENND1A | DENN/MADD domain containing 1A | 0.034383 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0336709 |
| COL5A1 | collagen, type V, alpha 1 | 0.0334393 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0334085 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0331329 |
| FRMD4A | FERM domain containing 4A | 0.0328364 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0324818 |
| LOXL2 | lysyl oxidase-like 2 | 0.0324366 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0322903 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0321764 |
| ZNF292 | zinc finger protein 292 | 0.0321344 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0320753 |
| AHNAK | AHNAK nucleoprotein | 0.0318848 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0314064 |
| RPS6 | ribosomal protein S6 | 0.0313384 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0311897 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.0311188 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0309603 |
| FAM168A | family with sequence similarity 168, member A | 0.03055 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0305087 |
| FNBP4 | formin binding protein 4 | 0.030493 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0304204 |
| XPO1 | exportin 1 | 0.0303813 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.0303109 |
| DST | dystonin | 0.030031 |
| AUTS2 | autism susceptibility candidate 2 | 0.029905 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0294838 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.0286804 |
| RPL37A | ribosomal protein L37a | 0.028457 |
| YEATS2 | YEATS domain containing 2 | 0.02835 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0281336 |
| SP3 | Sp3 transcription factor | 0.0279004 |
| AFDN | afadin, adherens junction formation factor | 0.0278651 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0277908 |
| PGK1 | phosphoglycerate kinase 1 | 0.0275748 |
| SQSTM1 | sequestosome 1 | 0.0274369 |
| PCGF5 | polycomb group ring finger 5 | 0.0274208 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0273508 |
| CCND1 | cyclin D1 | 0.0273342 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0271565 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0270109 |
| MSN | moesin | 0.0267368 |
| SEC24A | SEC24 family member A | 0.0266818 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0266344 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0265726 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.334714 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.19693 |
| LOX | lysyl oxidase | -0.187086 |
| CD44 | CD44 molecule (Indian blood group) | -0.128541 |
| TMSB10 | thymosin beta 10 | -0.117966 |
| MAP1B | microtubule-associated protein 1B | -0.107963 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0963422 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0901306 |
| UBC | ubiquitin C | -0.0776908 |
| ANXA2 | annexin A2 | -0.0650336 |
| FBN1 | fibrillin 1 | -0.06197 |
| GLIS3 | GLIS family zinc finger 3 | -0.0603099 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0603046 |
| LDHA | lactate dehydrogenase A | -0.0598547 |
| VCL | vinculin | -0.0521579 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0472071 |
| NDRG1 | N-myc downstream regulated 1 | -0.0418941 |
| BSG | basigin (Ok blood group) | -0.0411396 |
| POTEF | POTE ankyrin domain family, member F | -0.0401702 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0401236 |
| VIM | vimentin | -0.0391051 |
| PKM | pyruvate kinase, muscle | -0.0388268 |
| FTL | ferritin, light polypeptide | -0.0385911 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0385855 |
| S100A10 | S100 calcium binding protein A10 | -0.0380575 |
| MT2A | metallothionein 2A | -0.0367259 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0367135 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.035596 |
| TAGLN2 | transgelin 2 | -0.0340494 |
| PLAT | plasminogen activator, tissue | -0.0335877 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0328689 |
| MEIS2 | Meis homeobox 2 | -0.0327376 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0322935 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.031653 |
| TXNIP | thioredoxin interacting protein | -0.0305185 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0301208 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0295732 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0294596 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0288538 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0288529 |
| NPR2 | natriuretic peptide receptor 2 | -0.0275498 |
| CLIC4 | chloride intracellular channel 4 | -0.0268495 |
| SMYD3 | SET and MYND domain containing 3 | -0.0263998 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0263494 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0263192 |
| ACTN4 | actinin, alpha 4 | -0.0256857 |
| RAI14 | retinoic acid induced 14 | -0.0256532 |
| TXNRD1 | thioredoxin reductase 1 | -0.0256067 |
| COL5A2 | collagen, type V, alpha 2 | -0.0253417 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0243194 |
| EGR1 | early growth response 1 | -0.0236944 |
| SVIL | supervillin | -0.0236695 |
| PFN1 | profilin 1 | -0.02361 |
| CENPF | centromere protein F, 350/400kDa | -0.0233087 |
| TAPBP | TAP binding protein (tapasin) | -0.0230636 |
| EHBP1 | EH domain binding protein 1 | -0.0229024 |
| MAP4 | microtubule-associated protein 4 | -0.0226589 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0225717 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0221756 |
| SETX | senataxin | -0.0220942 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0215042 |
| CLTC | clathrin, heavy chain (Hc) | -0.0214841 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0211595 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0211534 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0206466 |
| COL1A2 | collagen, type I, alpha 2 | -0.0205663 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0205558 |
| IPO9 | importin 9 | -0.0204402 |
| ARF1 | ADP-ribosylation factor 1 | -0.0200566 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0196809 |
| RTN3 | reticulon 3 | -0.0196276 |
| HLA-E | major histocompatibility complex, class I, E | -0.0195534 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0194372 |
| VDAC1 | voltage-dependent anion channel 1 | -0.019429 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.019315 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0191348 |
| HDLBP | high density lipoprotein binding protein | -0.0191235 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0190391 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.01901 |
| RASAL2 | RAS protein activator like 2 | -0.0188921 |
| SP100 | SP100 nuclear antigen | -0.0184378 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0181956 |
| RAB7A | RAB7A, member RAS oncogene family | -0.018139 |
| PXDN | peroxidasin | -0.0181327 |
| ZNF207 | zinc finger protein 207 | -0.018094 |
| CSTB | cystatin B (stefin B) | -0.0180938 |
| S100A6 | S100 calcium binding protein A6 | -0.0177678 |
| RIGI | RNA sensor RIG-I | -0.0177543 |
| FAM114A1 | family with sequence similarity 114, member A1 | -0.0177353 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0175991 |
| OSMR | oncostatin M receptor | -0.0175983 |
| HEG1 | heart development protein with EGF-like domains 1 | -0.01751 |
| JMJD1C | jumonji domain containing 1C | -0.017457 |
| TRABD2B | TraB domain containing 2B | -0.0174134 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | -0.0172739 |
| INTS6 | integrator complex subunit 6 | -0.0170334 |
| RFTN1 | raftlin, lipid raft linker 1 | -0.0166012 |
| SEPTIN7 | septin 7 | -0.0164411 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0161362 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0161216 |
