| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.16847 |
| AREG | amphiregulin | 0.0847349 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0840022 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0730853 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0707335 |
| CCN2 | cellular communication network factor 2 | 0.0663254 |
| CCNL1 | cyclin L1 | 0.0617156 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0584818 |
| ACTG1 | actin gamma 1 | 0.0553107 |
| ATP11A | ATPase, class VI, type 11A | 0.0543653 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0541539 |
| ANXA1 | annexin A1 | 0.0520553 |
| YBX3 | Y box binding protein 3 | 0.0509365 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.050719 |
| TPM3 | tropomyosin 3 | 0.0496541 |
| RPL3 | ribosomal protein L3 | 0.047893 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.047135 |
| PCBP2 | poly(rC) binding protein 2 | 0.0469719 |
| RRM2 | ribonucleotide reductase M2 | 0.0463469 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0463054 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0455073 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0442969 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0439377 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0434548 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0434152 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0432445 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0428264 |
| TMEM41B | transmembrane protein 41B | 0.0423355 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0421711 |
| CPOX | coproporphyrinogen oxidase | 0.0420408 |
| CALR | calreticulin | 0.0415601 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0411155 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0400488 |
| HLA-A | major histocompatibility complex, class I, A | 0.0376649 |
| CLDND1 | claudin domain containing 1 | 0.036956 |
| HDGF | hepatoma-derived growth factor | 0.0365503 |
| MKI67 | marker of proliferation Ki-67 | 0.0363735 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0360006 |
| TXNRD1 | thioredoxin reductase 1 | 0.0359518 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0357175 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.0355693 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0353774 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0347197 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0337885 |
| ECT2 | epithelial cell transforming 2 | 0.0337734 |
| YBX1 | Y box binding protein 1 | 0.0335915 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0333403 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0330891 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0329077 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.032519 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0325163 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0321318 |
| BRD2 | bromodomain containing 2 | 0.0318092 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0313536 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0313486 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.0309414 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0309405 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0305653 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0304718 |
| CEP192 | centrosomal protein 192kDa | 0.0304041 |
| RPL7A | ribosomal protein L7a | 0.0302763 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0301826 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0301264 |
| KLC1 | kinesin light chain 1 | 0.030082 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0298719 |
| ENAH | enabled homolog (Drosophila) | 0.0294332 |
| CASC3 | cancer susceptibility candidate 3 | 0.0289996 |
| FLNA | filamin A, alpha | 0.0284635 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0284422 |
| AXIN2 | axin 2 | 0.0282261 |
| DDX42 | DEAD (Asp-Glu-Ala-Asp) box helicase 42 | 0.0279617 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0279448 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0278885 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0278588 |
| DIAPH1 | diaphanous-related formin 1 | 0.0278157 |
| MCL1 | myeloid cell leukemia 1 | 0.02781 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0277394 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0275938 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0272411 |
| SFTPA2 | surfactant protein A2 | 0.0270926 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.0270299 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.0269648 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0268606 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0264369 |
| RTN4 | reticulon 4 | 0.0264266 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0263877 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0261316 |
| CEP250 | centrosomal protein 250kDa | 0.0258629 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.0257704 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 0.0256727 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0254656 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.0254473 |
| EZR | ezrin | 0.025363 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0252651 |
| SET | SET nuclear proto-oncogene | 0.0252564 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0252286 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.0251778 |
| DCTN1 | dynactin 1 | 0.0250019 |
| LDHB | lactate dehydrogenase B | 0.0246836 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0246365 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.193615 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.17141 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0939563 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0740596 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0720095 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0693811 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0677657 |
| TMSB10 | thymosin beta 10 | -0.0642615 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0638099 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0626454 |
| EHBP1 | EH domain binding protein 1 | -0.061938 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0600867 |
| FTL | ferritin, light polypeptide | -0.059757 |
| VIM | vimentin | -0.0571114 |
| HMGA1 | high mobility group AT-hook 1 | -0.055781 |
| HMGA2 | high mobility group AT-hook 2 | -0.0546524 |
| MMP12 | matrix metallopeptidase 12 | -0.0521367 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0517524 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0508363 |
| RPLP1 | ribosomal protein, large, P1 | -0.0489864 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.04866 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0467255 |
| JMJD1C | jumonji domain containing 1C | -0.0443449 |
| CANX | calnexin | -0.0434762 |
| RPL35A | ribosomal protein L35a | -0.0421847 |
| RPLP0 | ribosomal protein, large, P0 | -0.0418485 |
| RPS6 | ribosomal protein S6 | -0.0412783 |
| RPL34 | ribosomal protein L34 | -0.0380853 |
| RPS24 | ribosomal protein S24 | -0.0370017 |
| HMGB1 | high mobility group box 1 | -0.036112 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0341763 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0340985 |
| NF1 | neurofibromin 1 | -0.0340831 |
| PFN1 | profilin 1 | -0.0335712 |
| H1-0 | H1.0 linker histone | -0.033287 |
| ZNF804A | zinc finger protein 804A | -0.0332599 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0328427 |
| PCDH7 | protocadherin 7 | -0.0305816 |
| S100A6 | S100 calcium binding protein A6 | -0.0289966 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0287638 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0285887 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0276058 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0275884 |
| INTS6 | integrator complex subunit 6 | -0.0272279 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0271357 |
| CCND1 | cyclin D1 | -0.0270202 |
| CLDN1 | claudin 1 | -0.0267803 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0263621 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0260884 |
| RPS27A | ribosomal protein S27a | -0.026066 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0252955 |
| RPLP2 | ribosomal protein, large, P2 | -0.0250929 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0249191 |
| RPL27A | ribosomal protein L27a | -0.0248119 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0245099 |
| ELP4 | elongator acetyltransferase complex subunit 4 | -0.0244818 |
| BCHE | butyrylcholinesterase | -0.0244291 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0244176 |
| CUX1 | cut-like homeobox 1 | -0.0238088 |
| RPL38 | ribosomal protein L38 | -0.0233322 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0228044 |
| RPL12 | ribosomal protein L12 | -0.0227903 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0227166 |
| RTN3 | reticulon 3 | -0.022704 |
| DIAPH2 | diaphanous-related formin 2 | -0.0224331 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0223081 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0222999 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0221198 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0220948 |
| CD2AP | CD2-associated protein | -0.022028 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0219918 |
| WWOX | WW domain containing oxidoreductase | -0.0216972 |
| EXOC4 | exocyst complex component 4 | -0.0213261 |
| MTAP | methylthioadenosine phosphorylase | -0.0212966 |
| EGR1 | early growth response 1 | -0.0211623 |
| FSTL5 | follistatin-like 5 | -0.0206291 |
| MAP4 | microtubule-associated protein 4 | -0.0203006 |
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | -0.0201811 |
| RPL10A | ribosomal protein L10a | -0.0201519 |
| RPS8 | ribosomal protein S8 | -0.0201512 |
| DEK | DEK proto-oncogene | -0.0199176 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0198224 |
| SYT1 | synaptotagmin I | -0.0197705 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0197373 |
| MORF4L2 | mortality factor 4 like 2 | -0.0196889 |
| ENO1 | enolase 1, (alpha) | -0.0196363 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0195462 |
| PAIP2 | poly(A) binding protein interacting protein 2 | -0.0193192 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0192339 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0189934 |
| ADIPOR2 | adiponectin receptor 2 | -0.0187873 |
| THSD7A | thrombospondin, type I, domain containing 7A | -0.0186021 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0185702 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0185408 |
| LRRC23 | leucine rich repeat containing 23 | -0.0184119 |
| R3HDM1 | R3H domain containing 1 | -0.0183284 |
| RSL24D1 | ribosomal L24 domain containing 1 | -0.0182696 |
| VMP1 | vacuole membrane protein 1 | -0.0181474 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0181099 |
| RAB1A | RAB1A, member RAS oncogene family | -0.017929 |
