| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0870697 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0870581 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0849293 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0738355 |
| MSN | moesin | 0.07377 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0680143 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0659825 |
| NRP2 | neuropilin 2 | 0.0659132 |
| TPM3 | tropomyosin 3 | 0.0654955 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0639947 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.062965 |
| SMAD3 | SMAD family member 3 | 0.0577588 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0560999 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0552559 |
| CENPF | centromere protein F, 350/400kDa | 0.0544947 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0538638 |
| VEGFA | vascular endothelial growth factor A | 0.0513138 |
| SP3 | Sp3 transcription factor | 0.0507048 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0482425 |
| CD44 | CD44 molecule (Indian blood group) | 0.0481847 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0469234 |
| MKI67 | marker of proliferation Ki-67 | 0.0458518 |
| ARRDC3 | arrestin domain containing 3 | 0.0455704 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0451236 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.045039 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0447275 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0442741 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0440267 |
| SET | SET nuclear proto-oncogene | 0.0430236 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0420181 |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.0417652 |
| ANXA5 | annexin A5 | 0.0417318 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0411956 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0409772 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.0402544 |
| PAX8 | paired box 8 | 0.0394082 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0381467 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0379597 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0378592 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0377121 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0369998 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0364742 |
| IRS2 | insulin receptor substrate 2 | 0.0360255 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0359078 |
| HDGF | hepatoma-derived growth factor | 0.0353284 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0345134 |
| NRP1 | neuropilin 1 | 0.0344834 |
| CALU | calumenin | 0.0344752 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0340205 |
| RAI14 | retinoic acid induced 14 | 0.0336267 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0335786 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0335173 |
| RTN4 | reticulon 4 | 0.0334515 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0328783 |
| CDCP1 | CUB domain containing protein 1 | 0.0328032 |
| GOLGA4 | golgin A4 | 0.0324466 |
| LOXL2 | lysyl oxidase-like 2 | 0.0322855 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0321275 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0319233 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0315597 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0315308 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0310735 |
| NAV2 | neuron navigator 2 | 0.0308873 |
| OPTN | optineurin | 0.0307719 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0306205 |
| TGFB2 | transforming growth factor, beta 2 | 0.0299164 |
| TPR | translocated promoter region, nuclear basket protein | 0.0298863 |
| B2M | beta-2-microglobulin | 0.0293268 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0286376 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0285521 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.028479 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0283933 |
| CALR | calreticulin | 0.02832 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0281682 |
| SETD5 | SET domain containing 5 | 0.0280508 |
| ZNF652 | zinc finger protein 652 | 0.0280357 |
| FAT1 | FAT atypical cadherin 1 | 0.027977 |
| THOC2 | THO complex 2 | 0.0277398 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0277018 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0276501 |
| RNF220 | ring finger protein 220 | 0.0275794 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.02739 |
| PLIN2 | perilipin 2 | 0.0268207 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0268045 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0267104 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0267031 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.0265507 |
| LAMB1 | laminin, beta 1 | 0.0265452 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0259497 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0259311 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0257285 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0256066 |
| TRIM56 | tripartite motif containing 56 | 0.0253272 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0251343 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0250949 |
| ATXN10 | ataxin 10 | 0.0249835 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0249752 |
| SEPTIN9 | septin 9 | 0.0246374 |
| CAAP1 | caspase activity and apoptosis inhibitor 1 | 0.024597 |
| HAUS6 | HAUS augmin-like complex, subunit 6 | 0.0245154 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.262102 |
| FTL | ferritin, light polypeptide | -0.156806 |
| FRMD4A | FERM domain containing 4A | -0.152838 |
| TMSB10 | thymosin beta 10 | -0.145373 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.128036 |
| ICAM1 | intercellular adhesion molecule 1 | -0.108099 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0930122 |
| INTS6 | integrator complex subunit 6 | -0.0742298 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0724163 |
| GPC6 | glypican 6 | -0.0719169 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0657937 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0614623 |
| RPLP1 | ribosomal protein, large, P1 | -0.0604659 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0590138 |
| RPL34 | ribosomal protein L34 | -0.0584224 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.056471 |
| PALLD | palladin, cytoskeletal associated protein | -0.0564282 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0561417 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0536972 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0520893 |
| CTSD | cathepsin D | -0.0518193 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0510619 |
| RPL35A | ribosomal protein L35a | -0.0505691 |
| ARF1 | ADP-ribosylation factor 1 | -0.0495598 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0494536 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0482401 |
| RPS24 | ribosomal protein S24 | -0.0469019 |
| SDCBP | syndecan binding protein (syntenin) | -0.0462195 |
| RHEB | Ras homolog enriched in brain | -0.0457766 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0451064 |
| HBP1 | HMG-box transcription factor 1 | -0.0442739 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.043203 |
| RIGI | RNA sensor RIG-I | -0.0430223 |
| G0S2 | G0/G1 switch 2 | -0.0422515 |
| RAB1A | RAB1A, member RAS oncogene family | -0.041994 |
| UBC | ubiquitin C | -0.041834 |
| VCL | vinculin | -0.0417065 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0413309 |
| SPAG9 | sperm associated antigen 9 | -0.0409318 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0401433 |
| RPLP0 | ribosomal protein, large, P0 | -0.0399615 |
| HMGB1 | high mobility group box 1 | -0.0398536 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0395062 |
| SP100 | SP100 nuclear antigen | -0.0389993 |
| RPS5 | ribosomal protein S5 | -0.0389444 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0387025 |
| NDRG1 | N-myc downstream regulated 1 | -0.0386412 |
| GLIS3 | GLIS family zinc finger 3 | -0.0382934 |
| KYNU | kynureninase | -0.0380624 |
| PFN1 | profilin 1 | -0.0379795 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0372655 |
| RPL28 | ribosomal protein L28 | -0.0371152 |
| LMNA | lamin A/C | -0.0366242 |
| RPS20 | ribosomal protein S20 | -0.036624 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0365979 |
| GDF15 | growth differentiation factor 15 | -0.03616 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0360432 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0358655 |
| ATF3 | activating transcription factor 3 | -0.0356919 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.034569 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0343678 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0343559 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.034316 |
| EPAS1 | endothelial PAS domain protein 1 | -0.033657 |
| CTBP2 | C-terminal binding protein 2 | -0.0332571 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0328919 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0328022 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0323007 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0318448 |
| GNAS | GNAS complex locus | -0.031819 |
| CAVIN1 | caveolae associated protein 1 | -0.0314975 |
| TLE4 | transducin-like enhancer of split 4 | -0.0311666 |
| RPL23 | ribosomal protein L23 | -0.0307563 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0303434 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0301751 |
| RPS8 | ribosomal protein S8 | -0.0300519 |
| ZNF644 | zinc finger protein 644 | -0.0299099 |
| PKM | pyruvate kinase, muscle | -0.0298697 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0298556 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0297326 |
| QKI | QKI, KH domain containing, RNA binding | -0.0297315 |
| EFNA5 | ephrin-A5 | -0.0295223 |
| RPL8 | ribosomal protein L8 | -0.0294983 |
| TKT | transketolase | -0.0294257 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0293289 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0292853 |
| CRY1 | cryptochrome circadian clock 1 | -0.0292006 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0291439 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.028791 |
| CDK14 | cyclin-dependent kinase 14 | -0.0287077 |
| S100A10 | S100 calcium binding protein A10 | -0.0281922 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0281117 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0280793 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0275998 |
| UBAP2 | ubiquitin associated protein 2 | -0.0275669 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | -0.0274707 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0273812 |
| RPL31 | ribosomal protein L31 | -0.0273453 |
| ATF6 | activating transcription factor 6 | -0.0268314 |
| RPL19 | ribosomal protein L19 | -0.0267852 |
