| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.202584 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.109438 |
| SMAD3 | SMAD family member 3 | 0.0968684 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0955572 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0728467 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0672311 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.055897 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0548375 |
| RNF213 | ring finger protein 213 | 0.0544471 |
| PLEC | plectin | 0.0507307 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0496336 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0487619 |
| PTMA | prothymosin, alpha | 0.0462654 |
| FLNA | filamin A, alpha | 0.0345053 |
| C1D | C1D nuclear receptor corepressor | 0.033958 |
| HELZ | helicase with zinc finger | 0.0320214 |
| TMSB4X | thymosin beta 4, X-linked | 0.0320031 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0317308 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0315251 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0294025 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0292213 |
| USP3 | ubiquitin specific peptidase 3 | 0.0284162 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.0282533 |
| FDXR | ferredoxin reductase | 0.0281924 |
| XPC | xeroderma pigmentosum, complementation group C | 0.0280735 |
| ACTN4 | actinin, alpha 4 | 0.0276113 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0275597 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0265539 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0264793 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0262246 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0260851 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0259673 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0258048 |
| WDR43 | WD repeat domain 43 | 0.0256913 |
| CMIP | c-Maf inducing protein | 0.0256818 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0253007 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0250281 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0246836 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0246701 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0245532 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0239298 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0239212 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0233737 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0230194 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0227077 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0227036 |
| ADM | adrenomedullin | 0.0226305 |
| NUP58 | nucleoporin 58 | 0.0220161 |
| RPL7A | ribosomal protein L7a | 0.0220069 |
| RPL3 | ribosomal protein L3 | 0.0218705 |
| FLNB | filamin B, beta | 0.0218329 |
| CALU | calumenin | 0.0212984 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0207592 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0206739 |
| YBX3 | Y box binding protein 3 | 0.0206421 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0205163 |
| CCNL1 | cyclin L1 | 0.0202332 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0201968 |
| BCL2L1 | BCL2-like 1 | 0.0201351 |
| FMNL2 | formin-like 2 | 0.0199428 |
| LTBP4 | latent transforming growth factor beta binding protein 4 | 0.0199362 |
| CASC3 | cancer susceptibility candidate 3 | 0.0199319 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0198139 |
| ACTG1 | actin gamma 1 | 0.0196685 |
| TNS1 | tensin 1 | 0.0196484 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0195556 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0195479 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.019348 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0191313 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0190641 |
| TPM3 | tropomyosin 3 | 0.0189682 |
| MYOF | myoferlin | 0.0187057 |
| TFG | TRK-fused gene | 0.0186539 |
| PMM2 | phosphomannomutase 2 | 0.0186086 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0185079 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0185045 |
| RPL18 | ribosomal protein L18 | 0.0184811 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0182932 |
| HDGF | hepatoma-derived growth factor | 0.0181881 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | 0.0181383 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0180796 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.0180057 |
| FAM13A | family with sequence similarity 13, member A | 0.0178635 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0177011 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0176837 |
| MINK1 | misshapen-like kinase 1 | 0.0176084 |
| GOLGA4 | golgin A4 | 0.0173042 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0172333 |
| OPTN | optineurin | 0.0172059 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0171872 |
| HNRNPUL1 | heterogeneous nuclear ribonucleoprotein U-like 1 | 0.0170992 |
| AHNAK | AHNAK nucleoprotein | 0.0170668 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0170605 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0170589 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0170114 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0169794 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.016926 |
| SPAG9 | sperm associated antigen 9 | 0.0168607 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.0168572 |
| CLTC | clathrin, heavy chain (Hc) | 0.0166526 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.3076 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.166597 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.130034 |
| KYNU | kynureninase | -0.115471 |
| VIM | vimentin | -0.11357 |
| EFNA5 | ephrin-A5 | -0.10742 |
| TMSB10 | thymosin beta 10 | -0.100813 |
| STC1 | stanniocalcin 1 | -0.0939494 |
| RPLP1 | ribosomal protein, large, P1 | -0.0913987 |
| NDRG1 | N-myc downstream regulated 1 | -0.0818473 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0806215 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.080582 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0793487 |
| ASPH | aspartate beta-hydroxylase | -0.0777285 |
| PDE10A | phosphodiesterase 10A | -0.0731496 |
| VCL | vinculin | -0.0702313 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0675478 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0644059 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0566652 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0555753 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0550826 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0546086 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0510391 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0486449 |
| RPL35A | ribosomal protein L35a | -0.0484993 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0482594 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0446436 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0441482 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0438527 |
| FTL | ferritin, light polypeptide | -0.0433503 |
| S100A6 | S100 calcium binding protein A6 | -0.0431138 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0430601 |
| GPC6 | glypican 6 | -0.0405398 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0369822 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0368924 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0368646 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.036486 |
| RPLP0 | ribosomal protein, large, P0 | -0.0360589 |
| RPS23 | ribosomal protein S23 | -0.0354032 |
| EHBP1 | EH domain binding protein 1 | -0.0353482 |
| RPS16 | ribosomal protein S16 | -0.034762 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0347289 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0345193 |
| RPS6 | ribosomal protein S6 | -0.0345089 |
| EGR1 | early growth response 1 | -0.0343172 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0342103 |
| RAI14 | retinoic acid induced 14 | -0.033756 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0333791 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0331885 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0329398 |
| RPS8 | ribosomal protein S8 | -0.0327574 |
| LDHA | lactate dehydrogenase A | -0.0320845 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0317222 |
| RPL34 | ribosomal protein L34 | -0.0316661 |
| VMP1 | vacuole membrane protein 1 | -0.0315053 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0309657 |
| KRT81 | keratin 81, type II | -0.0301016 |
| RPL31 | ribosomal protein L31 | -0.0300482 |
| FBXO11 | F-box protein 11 | -0.0298434 |
| PDLIM5 | PDZ and LIM domain 5 | -0.029416 |
| SP100 | SP100 nuclear antigen | -0.0288246 |
| HMGA2 | high mobility group AT-hook 2 | -0.0286728 |
| RPS13 | ribosomal protein S13 | -0.0284201 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0282465 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0281182 |
| AUTS2 | autism susceptibility candidate 2 | -0.0279879 |
| MT2A | metallothionein 2A | -0.0277543 |
| RPL23 | ribosomal protein L23 | -0.0276343 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0273816 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.027007 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0268386 |
| RPS5 | ribosomal protein S5 | -0.0268174 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0267875 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0266002 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0265769 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0264838 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0264489 |
| WWOX | WW domain containing oxidoreductase | -0.0264136 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0262345 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0261299 |
| JMJD1C | jumonji domain containing 1C | -0.0260047 |
| RPS24 | ribosomal protein S24 | -0.0258364 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0253298 |
| PRKCA | protein kinase C, alpha | -0.0252484 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0249846 |
| RPS29 | ribosomal protein S29 | -0.0249759 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0248965 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0248326 |
| INTS6 | integrator complex subunit 6 | -0.0246884 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0245491 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0244389 |
| RAD51B | RAD51 paralog B | -0.0242404 |
| CD44 | CD44 molecule (Indian blood group) | -0.0238816 |
| DIAPH2 | diaphanous-related formin 2 | -0.0237336 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0236506 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0236096 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0234283 |
| EGFR | epidermal growth factor receptor | -0.0232561 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0231493 |
| RPL12 | ribosomal protein L12 | -0.0231287 |
