| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in AN3 CA cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MEST | mesoderm specific transcript | 0.158578 |
| VEGFA | vascular endothelial growth factor A | 0.113772 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.112048 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.10746 |
| RPS2 | ribosomal protein S2 | 0.0975887 |
| CALR | calreticulin | 0.0850311 |
| PTMA | prothymosin, alpha | 0.0829963 |
| MED13L | mediator complex subunit 13-like | 0.0815482 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0742263 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0626602 |
| OGA | O-GlcNAcase | 0.0565529 |
| TMSB4X | thymosin beta 4, X-linked | 0.0560457 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0554144 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0540927 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0503509 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0499491 |
| RPS3 | ribosomal protein S3 | 0.048315 |
| GOLGA4 | golgin A4 | 0.0464612 |
| COL1A2 | collagen, type I, alpha 2 | 0.0463042 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0460699 |
| CCNL1 | cyclin L1 | 0.0456239 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0456163 |
| YEATS2 | YEATS domain containing 2 | 0.0430198 |
| SEPTIN11 | septin 11 | 0.042632 |
| ZNF292 | zinc finger protein 292 | 0.0422527 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0419756 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0412698 |
| H1-4 | H1.4 linker histone, cluster member | 0.0404453 |
| KLHDC10 | kelch domain containing 10 | 0.0397318 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0394886 |
| H1-2 | H1.2 linker histone, cluster member | 0.0388458 |
| NUP58 | nucleoporin 58 | 0.0384797 |
| TET1 | tet methylcytosine dioxygenase 1 | 0.037229 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0365277 |
| PRELID2 | PRELI domain containing 2 | 0.0359265 |
| MALSU1 | mitochondrial assembly of ribosomal large subunit 1 | 0.0356667 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0353904 |
| CANX | calnexin | 0.0351872 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0350003 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0347976 |
| QKI | QKI, KH domain containing, RNA binding | 0.0338647 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0335987 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0334976 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0330057 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0329637 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0328796 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0327033 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0323662 |
| XPO1 | exportin 1 | 0.0320514 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0318492 |
| RSBN1L | round spermatid basic protein 1-like | 0.0315996 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0315634 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0314621 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.030942 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0308376 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0307231 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0306297 |
| VPS41 | vacuolar protein sorting 41 homolog (S. cerevisiae) | 0.0295635 |
| RNF145 | ring finger protein 145 | 0.0287472 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0286992 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0284985 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0284159 |
| CD70 | CD70 molecule | 0.0284119 |
| SET | SET nuclear proto-oncogene | 0.0282663 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0278465 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.027792 |
| VIRMA | vir like m6A methyltransferase associated | 0.0275378 |
| SGCE | sarcoglycan, epsilon | 0.0274624 |
| CASC3 | cancer susceptibility candidate 3 | 0.0273668 |
| RPS10 | ribosomal protein S10 | 0.0271739 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0271249 |
| MLEC | malectin | 0.0270962 |
| ANXA5 | annexin A5 | 0.0269897 |
| SUCO | SUN domain containing ossification factor | 0.0269742 |
| HDAC3 | histone deacetylase 3 | 0.0269131 |
| FAM13A | family with sequence similarity 13, member A | 0.0265364 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0264429 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0263214 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.0262939 |
| SETD5 | SET domain containing 5 | 0.0262534 |
| DYNC1LI1 | dynein, cytoplasmic 1, light intermediate chain 1 | 0.026067 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.02567 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0256074 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0254238 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0253112 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0251147 |
| SLMAP | sarcolemma associated protein | 0.0250233 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | 0.025008 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0249906 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0249554 |
| CALD1 | caldesmon 1 | 0.0248203 |
| WDR11 | WD repeat domain 11 | 0.0247807 |
| BTBD3 | BTB (POZ) domain containing 3 | 0.0244434 |
| HACE1 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | 0.0244402 |
| ADM | adrenomedullin | 0.024408 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0243269 |
| GGNBP2 | gametogenetin binding protein 2 | 0.0243162 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | 0.0241263 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0240569 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0239213 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.213445 |
| CADM2 | cell adhesion molecule 2 | -0.162148 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.144997 |
| HMGA2 | high mobility group AT-hook 2 | -0.118187 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0988824 |
| VIM | vimentin | -0.0964281 |
| RPLP1 | ribosomal protein, large, P1 | -0.0855843 |
| PEG10 | paternally expressed 10 | -0.0820355 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0661478 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0660384 |
| EGR1 | early growth response 1 | -0.059867 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0587647 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0564556 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0552119 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0545501 |
| RPL34 | ribosomal protein L34 | -0.0517828 |
| RPL35A | ribosomal protein L35a | -0.0509901 |
| VCL | vinculin | -0.0489151 |
| JMJD1C | jumonji domain containing 1C | -0.0488167 |
| TPK1 | thiamin pyrophosphokinase 1 | -0.0474881 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0469823 |
| RPLP0 | ribosomal protein, large, P0 | -0.0466596 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0454049 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0450475 |
| TMSB10 | thymosin beta 10 | -0.04377 |
| TCF12 | transcription factor 12 | -0.0435069 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0423897 |
| RNF216 | ring finger protein 216 | -0.0417962 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0405806 |
| EXOC4 | exocyst complex component 4 | -0.0398393 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0393699 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0387586 |
| USP34 | ubiquitin specific peptidase 34 | -0.0378824 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0375309 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0369723 |
| PKM | pyruvate kinase, muscle | -0.0369172 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0362444 |
| PHF14 | PHD finger protein 14 | -0.0362414 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0358838 |
| PARD3 | par-3 family cell polarity regulator | -0.0357949 |
| CTBP2 | C-terminal binding protein 2 | -0.0352647 |
| EGFR | epidermal growth factor receptor | -0.0351593 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0343803 |
| FBXO11 | F-box protein 11 | -0.0341535 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0341515 |
| RPS24 | ribosomal protein S24 | -0.0339866 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0339003 |
| FAM193A | family with sequence similarity 193, member A | -0.0333803 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0331556 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0329474 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0328081 |
| DOCK3 | dedicator of cytokinesis 3 | -0.0326794 |
| FTL | ferritin, light polypeptide | -0.0326183 |
| ATP11A | ATPase, class VI, type 11A | -0.0325953 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.0321717 |
| POTEF | POTE ankyrin domain family, member F | -0.0315413 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0310803 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0309936 |
| ACTN4 | actinin, alpha 4 | -0.0308809 |
| E2F3 | E2F transcription factor 3 | -0.0308442 |
| LDHA | lactate dehydrogenase A | -0.0308101 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.0307146 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0304618 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0304397 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.030429 |
| LATS2 | large tumor suppressor kinase 2 | -0.0302555 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0301002 |
| ZNF644 | zinc finger protein 644 | -0.0296801 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0295329 |
| HMGA1 | high mobility group AT-hook 1 | -0.0291269 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0290201 |
| TULP4 | tubby like protein 4 | -0.0284907 |
| CMIP | c-Maf inducing protein | -0.0283869 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.028293 |
| RPL36 | ribosomal protein L36 | -0.0282238 |
| INTS6 | integrator complex subunit 6 | -0.0282068 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0279973 |
| HMGB1 | high mobility group box 1 | -0.0279871 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0279471 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0278288 |
| ARF1 | ADP-ribosylation factor 1 | -0.0277861 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0276923 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0276757 |
| MYOF | myoferlin | -0.027486 |
| MED13 | mediator complex subunit 13 | -0.0271422 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.026942 |
| SHROOM3 | shroom family member 3 | -0.0269335 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0268021 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0267269 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0267146 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0266422 |
| CDK13 | cyclin-dependent kinase 13 | -0.0265451 |
| RSU1 | Ras suppressor protein 1 | -0.0264031 |
| OLA1 | Obg-like ATPase 1 | -0.0263422 |
| AASS | aminoadipate-semialdehyde synthase | -0.0263153 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | -0.0262924 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | -0.0262592 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0262239 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0260541 |
| AGO3 | argonaute RISC catalytic component 3 | -0.02604 |
