Topotecan (hydrochloride)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Topotecan (hydrochloride) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Topotecan (hydrochloride)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS2 ribosomal protein S2 0.128836
FLNB filamin B, beta 0.124088
AKAP12 A kinase (PRKA) anchor protein 12 0.122908
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.105279
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0939055
SMAD3 SMAD family member 3 0.0925307
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0920204
RPL37A ribosomal protein L37a 0.0899836
BAIAP2L1 BAI1-associated protein 2-like 1 0.088985
RPS3 ribosomal protein S3 0.0870889
PTMA prothymosin, alpha 0.0834987
ACTG1 actin gamma 1 0.0691955
HSPA8 heat shock 70kDa protein 8 0.0687487
PLEC plectin 0.0682894
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0673104
MPRIP myosin phosphatase Rho interacting protein 0.0669693
PSD3 pleckstrin and Sec7 domain containing 3 0.0668095
DSPP dentin sialophosphoprotein 0.0666417
PDLIM5 PDZ and LIM domain 5 0.0638518
PRSS3 protease, serine, 3 0.062976
EFNA5 ephrin-A5 0.0627261
RBM39 RNA binding motif protein 39 0.0618322
OGA O-GlcNAcase 0.0612023
RPS12 ribosomal protein S12 0.0585323
PTK2 protein tyrosine kinase 2 0.0576573
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0574591
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0531637
CAPRIN2 caprin family member 2 0.0528858
ZEB1 zinc finger E-box binding homeobox 1 0.0527026
ITPRID2 ITPR interacting domain containing 2 0.0526481
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0518671
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0482648
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0478897
FAM107B family with sequence similarity 107, member B 0.0472616
MYH9 myosin, heavy chain 9, non-muscle 0.046786
DOCK5 dedicator of cytokinesis 5 0.0460979
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0458093
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0457032
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0454556
TPM3 tropomyosin 3 0.0446176
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0445337
OSBPL3 oxysterol binding protein-like 3 0.0444492
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0437472
LMTK2 lemur tyrosine kinase 2 0.0424935
DSG2 desmoglein 2 0.0423837
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0422652
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0420195
TNIP1 TNFAIP3 interacting protein 1 0.0411306
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0410328
NPAS2 neuronal PAS domain protein 2 0.0409366
RUNX1 runt-related transcription factor 1 0.0407665
TRA2A transformer 2 alpha homolog (Drosophila) 0.0404851
AFDN afadin, adherens junction formation factor 0.0403267
KTN1 kinectin 1 (kinesin receptor) 0.0396881
CTBP2 C-terminal binding protein 2 0.0396632
VCL vinculin 0.0389231
RPL7 ribosomal protein L7 0.0387939
RCOR1 REST corepressor 1 0.0386741
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0376022
PMM2 phosphomannomutase 2 0.0373961
MED13L mediator complex subunit 13-like 0.0360998
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0359202
RPL26 ribosomal protein L26 0.0359146
SLMAP sarcolemma associated protein 0.0358763
PON2 paraoxonase 2 0.0356983
MCU mitochondrial calcium uniporter 0.0354676
ATP13A3 ATPase type 13A3 0.0352524
FMNL2 formin-like 2 0.0350494
SULF2 sulfatase 2 0.0347868
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0347201
PUM2 pumilio RNA-binding family member 2 0.0344585
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0342682
COL17A1 collagen, type XVII, alpha 1 0.0342066
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0338545
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0330727
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0330531
RPS27A ribosomal protein S27a 0.0329361
KIF5B kinesin family member 5B 0.0327056
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0322834
B2M beta-2-microglobulin 0.0320335
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0318692
RPL11 ribosomal protein L11 0.0318586
THOC2 THO complex 2 0.0317641
SLTM SAFB-like, transcription modulator 0.03163
JMJD1C jumonji domain containing 1C 0.0314854
OPTN optineurin 0.0314518
EPS8 epidermal growth factor receptor pathway substrate 8 0.0312879
SLK STE20-like kinase 0.0310247
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0309413
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0308763
CAB39 calcium binding protein 39 0.0308093
MYO6 myosin VI 0.0306745
MACF1 microtubule-actin crosslinking factor 1 0.0305286
RPL5 ribosomal protein L5 0.03046
HPCAL1 hippocalcin-like 1 0.030039
RICTOR RPTOR independent companion of MTOR, complex 2 0.029998
RPL7A ribosomal protein L7a 0.0299085
EEF2 eukaryotic translation elongation factor 2 0.0297509
BCAR3 breast cancer anti-estrogen resistance 3 0.0297384
ZNF706 zinc finger protein 706 0.0296379

decreased expression

Symbol Name Standardized Value
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.167034
TXNRD1 thioredoxin reductase 1 -0.136749
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.115094
IGFBP3 insulin-like growth factor binding protein 3 -0.104318
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.103103
KLK10 kallikrein-related peptidase 10 -0.0955772
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0920001
NDRG1 N-myc downstream regulated 1 -0.0916847
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0905048
F3 coagulation factor III (thromboplastin, tissue factor) -0.0861892
TXNIP thioredoxin interacting protein -0.0854366
LAMB3 laminin, beta 3 -0.084877
SACK1A scaffolding CK1 anchoring protein A -0.0830046
FTL ferritin, light polypeptide -0.0801288
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0743712
VIM vimentin -0.0662498
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0651737
EGR1 early growth response 1 -0.061762
RPL35A ribosomal protein L35a -0.0581087
TM4SF1 transmembrane 4 L six family member 1 -0.0537872
FTH1 ferritin, heavy polypeptide 1 -0.0507081
TMSB10 thymosin beta 10 -0.0493285
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0491336
MUC17 mucin 17, cell surface associated -0.048584
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0477346
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0459931
POTEF POTE ankyrin domain family, member F -0.0425701
LOC112694756 uncharaterized LOC112694756 -0.0411751
TPM4 tropomyosin 4 -0.0404904
DIAPH2 diaphanous-related formin 2 -0.0403121
RAB7A RAB7A, member RAS oncogene family -0.0397203
MXD1 MAX dimerization protein 1 -0.0385557
KLF6 Kruppel-like factor 6 -0.0378598
LAMA4 laminin, alpha 4 -0.0364917
S100A10 S100 calcium binding protein A10 -0.0351599
AK1 adenylate kinase 1 -0.0343441
SLC38A2 solute carrier family 38, member 2 -0.0336082
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0319204
ARF4 ADP-ribosylation factor 4 -0.0309565
PERP PERP, TP53 apoptosis effector -0.0306834
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0303817
MIDN midnolin -0.0298009
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0297343
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0296483
CD44 CD44 molecule (Indian blood group) -0.0294515
ZMYND8 zinc finger, MYND-type containing 8 -0.0290904
ZBTB20 zinc finger and BTB domain containing 20 -0.0288924
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0288698
RPL27A ribosomal protein L27a -0.0284292
BLZF1 basic leucine zipper nuclear factor 1 -0.0282692
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0281744
S100A11 S100 calcium binding protein A11 -0.0279854
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.027539
FERMT1 fermitin family member 1 -0.0272353
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0271287
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0271056
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0268958
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0267065
ENO1 enolase 1, (alpha) -0.026672
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0266095
FAM3C family with sequence similarity 3, member C -0.0265393
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0262695
SKAP2 src kinase associated phosphoprotein 2 -0.0261864
AKAP9 A kinase (PRKA) anchor protein 9 -0.0258612
VCAN versican -0.0257543
KRT19 keratin 19, type I -0.0256651
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0249382
IFI16 interferon, gamma-inducible protein 16 -0.0247177
UBC ubiquitin C -0.0245091
DENND2C DENN/MADD domain containing 2C -0.0241039
LYZ lysozyme -0.0241013
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0240612
UBE2B ubiquitin-conjugating enzyme E2B -0.0234972
EGFR epidermal growth factor receptor -0.0234509
KPNB1 karyopherin (importin) beta 1 -0.0233941
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0232484
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0229233
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0227153
ANXA1 annexin A1 -0.0226851
RPL39 ribosomal protein L39 -0.0224792
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0224628
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0221446
ANTXR2 anthrax toxin receptor 2 -0.0217767
PFN1 profilin 1 -0.0215421
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0214979
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0211417
HDAC9 histone deacetylase 9 -0.0210559
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0206931
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0205188
TUBA1B tubulin, alpha 1b -0.0204821
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0204281
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0203312
IFI27 interferon, alpha-inducible protein 27 -0.0202632
ATP5F1E ATP synthase F1 subunit epsilon -0.020236
CLMP CXADR-like membrane protein -0.0202175
ADNP activity-dependent neuroprotector homeobox -0.0201422
ANKRD12 ankyrin repeat domain 12 -0.0200448
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0199561
CYBA cytochrome b-245, alpha polypeptide -0.0199212
TMCC3 transmembrane and coiled-coil domain family 3 -0.0195093