| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.146876 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.143231 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.129419 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.104381 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0962747 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0938097 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0811308 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0796562 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0733028 |
| SET | SET nuclear proto-oncogene | 0.0720228 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0673757 |
| DUSP16 | dual specificity phosphatase 16 | 0.065484 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0652572 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.0610052 |
| RAB22A | RAB22A, member RAS oncogene family | 0.0607043 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0600833 |
| VMP1 | vacuole membrane protein 1 | 0.0591944 |
| TOM1L1 | target of myb1 (chicken)-like 1 | 0.0569511 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.056104 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0551757 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0543068 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.051743 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0503041 |
| TC2N | tandem C2 domains, nuclear | 0.0461481 |
| CLTC | clathrin, heavy chain (Hc) | 0.045903 |
| ABHD17C | abhydrolase domain containing 17C | 0.0438041 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0437695 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0433479 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0431475 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0430575 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0423942 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0422367 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0420442 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0412419 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0411673 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0408423 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0397289 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0397139 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0382317 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.0381619 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0375444 |
| TPM3 | tropomyosin 3 | 0.036834 |
| MYO1B | myosin IB | 0.0356906 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0355923 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0354928 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0354912 |
| CAB39 | calcium binding protein 39 | 0.0353466 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.035255 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0349882 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0349357 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0347133 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0347037 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0346771 |
| GLCCI1 | glucocorticoid induced 1 | 0.034614 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.034188 |
| USP53 | ubiquitin specific peptidase 53 | 0.0334378 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.033309 |
| IFNGR1 | interferon gamma receptor 1 | 0.0321295 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0319117 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0318921 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.0317836 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0315936 |
| DOCK5 | dedicator of cytokinesis 5 | 0.031283 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0310996 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0309214 |
| STARD3 | StAR-related lipid transfer (START) domain containing 3 | 0.0301451 |
| SETX | senataxin | 0.0300667 |
| TXNRD1 | thioredoxin reductase 1 | 0.0300114 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0300093 |
| RGS6 | regulator of G-protein signaling 6 | 0.0298613 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.029706 |
| CDH15 | cadherin 15, type 1, M-cadherin (myotubule) | 0.0296402 |
| SERINC3 | serine incorporator 3 | 0.0293518 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | 0.0291258 |
| STK4 | serine/threonine kinase 4 | 0.0290545 |
| OSMR | oncostatin M receptor | 0.0290503 |
| LMO7 | LIM domain 7 | 0.0290416 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.029021 |
| PPP1R9B | protein phosphatase 1, regulatory subunit 9B | 0.0289677 |
| TRIM37 | tripartite motif containing 37 | 0.028726 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0277322 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0276096 |
| S100A8 | S100 calcium binding protein A8 | 0.0275593 |
| NIBAN2 | niban apoptosis regulator 2 | 0.027041 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0263667 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0263274 |
| CFB | complement factor B | 0.0262144 |
| DSPP | dentin sialophosphoprotein | 0.0255281 |
| SDC4 | syndecan 4 | 0.0251482 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0251268 |
| UBE2QL1 | ubiquitin-conjugating enzyme E2Q family-like 1 | 0.025093 |
| PLEC | plectin | 0.0246887 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0246402 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0245372 |
| MAP7 | microtubule-associated protein 7 | 0.0244364 |
| TFRC | transferrin receptor | 0.024386 |
| TMSB4X | thymosin beta 4, X-linked | 0.0241836 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0241458 |
| FMNL2 | formin-like 2 | 0.0241287 |
| FRMD6 | FERM domain containing 6 | 0.0240964 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CATSPERB | catsper channel auxiliary subunit beta | -0.0971791 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0928378 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0889595 |
| INTS6 | integrator complex subunit 6 | -0.0869523 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0810218 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0803088 |
| NDRG1 | N-myc downstream regulated 1 | -0.070497 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0693749 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0626313 |
| ACTG1 | actin gamma 1 | -0.0622936 |
| SMYD3 | SET and MYND domain containing 3 | -0.0621843 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0615773 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | -0.0614375 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0606533 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0598466 |
| RAD51B | RAD51 paralog B | -0.0597709 |
| CDK12 | cyclin-dependent kinase 12 | -0.0593003 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.058696 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0570444 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0569752 |
| SP100 | SP100 nuclear antigen | -0.0558073 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0527345 |
| EXOC4 | exocyst complex component 4 | -0.0525705 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.052317 |
| LASP1 | LIM and SH3 protein 1 | -0.0521397 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0505988 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0502984 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0498026 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | -0.0490153 |
| PARD3 | par-3 family cell polarity regulator | -0.0488172 |
| DTNA | dystrobrevin, alpha | -0.0484863 |
| CEP250 | centrosomal protein 250kDa | -0.0478553 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0472506 |
| VCL | vinculin | -0.0462663 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.044808 |
| RPL35A | ribosomal protein L35a | -0.044798 |
| SBF2 | SET binding factor 2 | -0.0441071 |
| RBM47 | RNA binding motif protein 47 | -0.0438152 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.039549 |
| PLSCR2 | phospholipid scramblase 2 | -0.0394257 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0389156 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0387888 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0374717 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0366733 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0358688 |
| NEBL | nebulette | -0.0358074 |
| TNS3 | tensin 3 | -0.0349595 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0344373 |
| PTMA | prothymosin, alpha | -0.034405 |
| RPL37A | ribosomal protein L37a | -0.0339853 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0339444 |
| KRT86 | keratin 86, type II | -0.0335427 |
| PLEKHG4B | pleckstrin homology domain containing, family G (with RhoGef domain) member 4B | -0.0335183 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0333982 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.0331153 |
| PRELID2 | PRELI domain containing 2 | -0.0325522 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.032311 |
| FASN | fatty acid synthase | -0.0321991 |
| PLSCR1 | phospholipid scramblase 1 | -0.0318764 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0317313 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0314339 |
| USO1 | USO1 vesicle transport factor | -0.0312245 |
| POTEF | POTE ankyrin domain family, member F | -0.0311068 |
| AEBP2 | AE binding protein 2 | -0.0309836 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0309094 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0306888 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.0303165 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0303083 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0301912 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0298013 |
| DENND1A | DENN/MADD domain containing 1A | -0.0297497 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0296018 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0294767 |
| CCND1 | cyclin D1 | -0.0293038 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0289203 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0286653 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0286212 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0284497 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0283953 |
| RPS3 | ribosomal protein S3 | -0.0283419 |
| BBX | bobby sox homolog (Drosophila) | -0.028225 |
| PGK1 | phosphoglycerate kinase 1 | -0.0278509 |
| ASPH | aspartate beta-hydroxylase | -0.0276478 |
| ST8SIA6 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 | -0.0275153 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | -0.0274877 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0274584 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0269706 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0269502 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0267257 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0266062 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0264859 |
| GOLGB1 | golgin B1 | -0.0264611 |
| ENO1 | enolase 1, (alpha) | -0.0260521 |
| RBPMS | RNA binding protein with multiple splicing | -0.0259331 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0257684 |
| EFNA5 | ephrin-A5 | -0.0254455 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0250092 |
| POLD3 | polymerase (DNA-directed), delta 3, accessory subunit | -0.0249641 |
| ZNF207 | zinc finger protein 207 | -0.0249619 |
| GOLGA4 | golgin A4 | -0.0244987 |
