| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in C-33 A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0938791 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0886757 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0752454 |
| NUP58 | nucleoporin 58 | 0.0646546 |
| ZNF292 | zinc finger protein 292 | 0.0633908 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0581995 |
| CABIN1 | calcineurin binding protein 1 | 0.0515921 |
| SETD5 | SET domain containing 5 | 0.0510589 |
| NGLY1 | N-glycanase 1 | 0.0510287 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0438597 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0436486 |
| HELZ | helicase with zinc finger | 0.0414847 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0401457 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0400409 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0396102 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0390061 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0380287 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0366763 |
| FAM168A | family with sequence similarity 168, member A | 0.0365093 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0364699 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0363318 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0360477 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0356147 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0338856 |
| ATRN | attractin | 0.0333173 |
| YEATS2 | YEATS domain containing 2 | 0.0320293 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.0320078 |
| QKI | QKI, KH domain containing, RNA binding | 0.031561 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0312519 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0309373 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0302604 |
| TBK1 | TANK-binding kinase 1 | 0.0300973 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0300257 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0295512 |
| CDC73 | cell division cycle 73 | 0.0293219 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0287108 |
| NBAS | neuroblastoma amplified sequence | 0.0285924 |
| CASC3 | cancer susceptibility candidate 3 | 0.0285912 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.028352 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0269584 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.02638 |
| OGA | O-GlcNAcase | 0.0255738 |
| PHIP | pleckstrin homology domain interacting protein | 0.0253295 |
| HACE1 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | 0.0249254 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0247353 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0244402 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0243975 |
| PTK2 | protein tyrosine kinase 2 | 0.0243187 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0240634 |
| INSIG2 | insulin induced gene 2 | 0.0239659 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0239557 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0239424 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0239232 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.0237328 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.0237184 |
| PTCH1 | patched 1 | 0.0236838 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0235782 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0234302 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0234189 |
| ZNF160 | zinc finger protein 160 | 0.0232137 |
| RTN4 | reticulon 4 | 0.0231104 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.023003 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0227133 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0227004 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0222407 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0218571 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0217538 |
| PNN | pinin, desmosome associated protein | 0.0216595 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.021536 |
| PCNX1 | pecanex 1 | 0.0215012 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0214296 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0210241 |
| VEGFA | vascular endothelial growth factor A | 0.0207589 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0206187 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0204441 |
| SPAG9 | sperm associated antigen 9 | 0.0203832 |
| SMAP1 | small ArfGAP 1 | 0.0203108 |
| RNF145 | ring finger protein 145 | 0.0201018 |
| KDM1A | lysine (K)-specific demethylase 1A | 0.0198821 |
| ADD1 | adducin 1 (alpha) | 0.0195075 |
| PCM1 | pericentriolar material 1 | 0.0194943 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0194611 |
| ARFGEF3 | ARFGEF family member 3 | 0.0193511 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0193417 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0192524 |
| MNMIP1 | manchette microtubule inner protein 1 | 0.0189363 |
| MED13L | mediator complex subunit 13-like | 0.0187161 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0184757 |
| RPL3 | ribosomal protein L3 | 0.0184186 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0183666 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0183102 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0182261 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0180993 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0179467 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0179346 |
| DST | dystonin | 0.0179107 |
| PDS5B | PDS5 cohesin associated factor B | 0.0178244 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0178127 |
| SERGEF | secretion regulating guanine nucleotide exchange factor | 0.0177874 |
| RBM33 | RNA binding motif protein 33 | 0.0176739 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.208319 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.205587 |
| RAD51B | RAD51 paralog B | -0.148724 |
| TENM3 | teneurin transmembrane protein 3 | -0.145564 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.109013 |
| NPAS3 | neuronal PAS domain protein 3 | -0.108184 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.107495 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.107389 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.102924 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.101579 |
| CADM2 | cell adhesion molecule 2 | -0.0932593 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0901059 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0881626 |
| CDH18 | cadherin 18, type 2 | -0.0875902 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0858725 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0708564 |
| TOX | thymocyte selection-associated high mobility group box | -0.0693193 |
| RPS6 | ribosomal protein S6 | -0.0624349 |
| RPLP1 | ribosomal protein, large, P1 | -0.0601828 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0590031 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.058108 |
| SHROOM3 | shroom family member 3 | -0.057405 |
| TMSB10 | thymosin beta 10 | -0.0534608 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0521774 |
| MLIP | muscular LMNA-interacting protein | -0.0513841 |
| RPL11 | ribosomal protein L11 | -0.0505672 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0505533 |
| LDHA | lactate dehydrogenase A | -0.0481738 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.046083 |
| TBC1D32 | TBC1 domain family, member 32 | -0.045062 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0449874 |
| RPLP0 | ribosomal protein, large, P0 | -0.0443974 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0437891 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0435913 |
| ACTG1 | actin gamma 1 | -0.0422317 |
| HMGA1 | high mobility group AT-hook 1 | -0.0409766 |
| RPS21 | ribosomal protein S21 | -0.0402872 |
| RPL28 | ribosomal protein L28 | -0.0388795 |
| PFN1 | profilin 1 | -0.0386733 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0378049 |
| RPL34 | ribosomal protein L34 | -0.0376711 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0375791 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0374686 |
| RIGI | RNA sensor RIG-I | -0.0373135 |
| RPS2 | ribosomal protein S2 | -0.0370928 |
| RPS24 | ribosomal protein S24 | -0.0369908 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0363918 |
| ENO1 | enolase 1, (alpha) | -0.0363657 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0357849 |
| MAP4 | microtubule-associated protein 4 | -0.0354148 |
| UBAP2 | ubiquitin associated protein 2 | -0.034695 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0345946 |
| HMGB1 | high mobility group box 1 | -0.0343896 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0340734 |
| PRICKLE1 | prickle homolog 1 (Drosophila) | -0.0340063 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0338666 |
| RPL12 | ribosomal protein L12 | -0.0336957 |
| RPLP2 | ribosomal protein, large, P2 | -0.033283 |
| COL5A2 | collagen, type V, alpha 2 | -0.0330406 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0328058 |
| RPS8 | ribosomal protein S8 | -0.0326266 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0324012 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0321917 |
| GNAS | GNAS complex locus | -0.0321684 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0319634 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0316531 |
| CCDC138 | coiled-coil domain containing 138 | -0.0314808 |
| NEBL | nebulette | -0.0313418 |
| TCF12 | transcription factor 12 | -0.0309594 |
| NRG1 | neuregulin 1 | -0.0300326 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.0298712 |
| BNC2 | basonuclin 2 | -0.0294595 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0291788 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.02903 |
| RANBP17 | RAN binding protein 17 | -0.0285296 |
| CENPF | centromere protein F, 350/400kDa | -0.02828 |
| RPS19 | ribosomal protein S19 | -0.0282414 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0281203 |
| KPNB1 | karyopherin (importin) beta 1 | -0.028084 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.027574 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0274496 |
| RPL32 | ribosomal protein L32 | -0.0272564 |
| NF1 | neurofibromin 1 | -0.0270226 |
| R3HDM1 | R3H domain containing 1 | -0.0267119 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0260796 |
| RPL18 | ribosomal protein L18 | -0.0260369 |
| PTMA | prothymosin, alpha | -0.0260219 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.02579 |
| VCL | vinculin | -0.025706 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0256689 |
| RPS12 | ribosomal protein S12 | -0.0256445 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0254662 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0250898 |
| MTAP | methylthioadenosine phosphorylase | -0.0250133 |
| AHI1 | Abelson helper integration site 1 | -0.024465 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0243491 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0243141 |
| RPS28 | ribosomal protein S28 | -0.0239582 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0238022 |
| CALD1 | caldesmon 1 | -0.0236794 |
