| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Topotecan (hydrochloride)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD109 | CD109 molecule | 0.131409 |
| FN1 | fibronectin 1 | 0.106142 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0988223 |
| CDC73 | cell division cycle 73 | 0.0951211 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0905204 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0876299 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0732235 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0703411 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0666169 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.0653227 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0616997 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0603492 |
| WDR43 | WD repeat domain 43 | 0.0598528 |
| FMNL2 | formin-like 2 | 0.0587186 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0578941 |
| RNF145 | ring finger protein 145 | 0.0562945 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0554566 |
| HELZ | helicase with zinc finger | 0.0536412 |
| NUP58 | nucleoporin 58 | 0.0507205 |
| GDF15 | growth differentiation factor 15 | 0.0495401 |
| ZNF292 | zinc finger protein 292 | 0.048939 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0485424 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.048342 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.0459497 |
| TPR | translocated promoter region, nuclear basket protein | 0.045464 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0454637 |
| CALR | calreticulin | 0.0447778 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0443801 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0430959 |
| RPS12 | ribosomal protein S12 | 0.042973 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.0423291 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0422009 |
| FBXO7 | F-box protein 7 | 0.0411946 |
| VEGFA | vascular endothelial growth factor A | 0.0403178 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0400033 |
| PHF21A | PHD finger protein 21A | 0.0393283 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.039115 |
| ADM | adrenomedullin | 0.0381743 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0375247 |
| VGF | VGF nerve growth factor inducible | 0.0374212 |
| PTK2 | protein tyrosine kinase 2 | 0.0372302 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0366907 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0366334 |
| SETD5 | SET domain containing 5 | 0.0363555 |
| FIP1L1 | factor interacting with PAPOLA and CPSF1 | 0.0354734 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0346994 |
| SMAD3 | SMAD family member 3 | 0.0344459 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0340255 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0339155 |
| GOLGA4 | golgin A4 | 0.0331712 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0330333 |
| PTMA | prothymosin, alpha | 0.032161 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 0.0318584 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0318021 |
| PKM | pyruvate kinase, muscle | 0.0317013 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0312302 |
| DCT | dopachrome tautomerase | 0.0312275 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0306973 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0306581 |
| FOSL1 | FOS-like antigen 1 | 0.0305807 |
| RPS19 | ribosomal protein S19 | 0.0303649 |
| RPL37A | ribosomal protein L37a | 0.0302854 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0301576 |
| RBM33 | RNA binding motif protein 33 | 0.0300113 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0297883 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0296104 |
| CABIN1 | calcineurin binding protein 1 | 0.0291368 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0291178 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.028973 |
| HOMER1 | homer scaffolding protein 1 | 0.0288575 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0281845 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0277455 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | 0.0276328 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0276232 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0273133 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0272198 |
| PIK3C3 | phosphatidylinositol 3-kinase, catalytic subunit type 3 | 0.0270985 |
| POM121 | POM121 transmembrane nucleoporin | 0.0270296 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0269158 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0266829 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0266707 |
| MKRN1 | makorin ring finger protein 1 | 0.0266056 |
| ZC3H7A | zinc finger CCCH-type containing 7A | 0.0260496 |
| ARL8B | ADP-ribosylation factor-like 8B | 0.0259123 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0256157 |
| FBXO42 | F-box protein 42 | 0.0249807 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0249307 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0248503 |
| NAV2 | neuron navigator 2 | 0.0240556 |
| CADM1 | cell adhesion molecule 1 | 0.0239851 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0239664 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0239651 |
| LNPK | lunapark, ER junction formation factor | 0.0239465 |
| RPS8 | ribosomal protein S8 | 0.0239416 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0237288 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0234658 |
| DENND1A | DENN/MADD domain containing 1A | 0.0232161 |
| RCOR1 | REST corepressor 1 | 0.0231066 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0230482 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0228964 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.222065 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.153782 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.151724 |
| FMN1 | formin 1 | -0.141972 |
| GPC6 | glypican 6 | -0.114049 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0907257 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.086291 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0755398 |
| POTEF | POTE ankyrin domain family, member F | -0.0729542 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0694835 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0687329 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0679142 |
| EGR1 | early growth response 1 | -0.0662389 |
| COL19A1 | collagen, type XIX, alpha 1 | -0.0650321 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0640052 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0606985 |
| A2M | alpha-2-macroglobulin | -0.0605075 |
| TAGLN2 | transgelin 2 | -0.0602574 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0598565 |
| VCL | vinculin | -0.0576573 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0559118 |
| TNNC1 | troponin C type 1 (slow) | -0.0537142 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0516247 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0505879 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0498043 |
| CENPF | centromere protein F, 350/400kDa | -0.0496056 |
| S100A6 | S100 calcium binding protein A6 | -0.049072 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0490703 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.04683 |
| CLIC4 | chloride intracellular channel 4 | -0.046519 |
| VIM | vimentin | -0.0464152 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0453197 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0452587 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0446851 |
| TPM4 | tropomyosin 4 | -0.0445826 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0437663 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0420024 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.041957 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0419053 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0404504 |
| ACTN1 | actinin, alpha 1 | -0.0401904 |
| ENO1 | enolase 1, (alpha) | -0.0398742 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0387186 |
| ATF6 | activating transcription factor 6 | -0.0370569 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -0.0367952 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0366081 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0365735 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0364947 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0362971 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0360554 |
| OSMR | oncostatin M receptor | -0.0359721 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0357863 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.035751 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0356119 |
| LDHA | lactate dehydrogenase A | -0.0352679 |
| MT2A | metallothionein 2A | -0.033612 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0335043 |
| MITF | microphthalmia-associated transcription factor | -0.0334318 |
| TCF12 | transcription factor 12 | -0.0331164 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0329243 |
| NRP2 | neuropilin 2 | -0.0326025 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0323558 |
| MACROD2 | MACRO domain containing 2 | -0.0321809 |
| SRPK2 | SRSF protein kinase 2 | -0.0316546 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | -0.0316113 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0316088 |
| BRD2 | bromodomain containing 2 | -0.031023 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0301071 |
| FRMD4A | FERM domain containing 4A | -0.0300374 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0299632 |
| MYO1E | myosin IE | -0.0299536 |
| CALD1 | caldesmon 1 | -0.0299196 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0298894 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0298037 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0297514 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0297261 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0296656 |
| PI15 | peptidase inhibitor 15 | -0.0292019 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0289493 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.028919 |
| TMSB10 | thymosin beta 10 | -0.0287804 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.028685 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0281507 |
| NAV1 | neuron navigator 1 | -0.028061 |
| RO60 | Ro60, Y RNA binding protein | -0.0279248 |
| NAV3 | neuron navigator 3 | -0.0279119 |
| NHSL1 | NHS-like 1 | -0.0279047 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.0278695 |
| LAMB1 | laminin, beta 1 | -0.0276733 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0276311 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.0275304 |
| RHOJ | ras homolog family member J | -0.0274516 |
| ZNF644 | zinc finger protein 644 | -0.0273107 |
| ATXN7L1 | ataxin 7-like 1 | -0.0271846 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.027017 |
| UBC | ubiquitin C | -0.027013 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0268914 |
| AHNAK | AHNAK nucleoprotein | -0.0267475 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0266153 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0265397 |
