| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in CFPAC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB4X | thymosin beta 4, X-linked | 0.131775 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.128502 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.117338 |
| PLAU | plasminogen activator, urokinase | 0.105786 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.102792 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0930824 |
| APP | amyloid beta (A4) precursor protein | 0.0917557 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0893826 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0881294 |
| B2M | beta-2-microglobulin | 0.0812433 |
| SMAD3 | SMAD family member 3 | 0.0810641 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0800614 |
| CCNL1 | cyclin L1 | 0.0783803 |
| RBM39 | RNA binding motif protein 39 | 0.0781818 |
| FAM13A | family with sequence similarity 13, member A | 0.0758138 |
| OGA | O-GlcNAcase | 0.0756993 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0696189 |
| PTMA | prothymosin, alpha | 0.0687454 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0681111 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0656455 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0653396 |
| SNAPC1 | small nuclear RNA activating complex, polypeptide 1, 43kDa | 0.0647765 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0633843 |
| BRD2 | bromodomain containing 2 | 0.0627331 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0626823 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0625383 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0625228 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0612761 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0603834 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0593076 |
| MT2A | metallothionein 2A | 0.0589845 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0583246 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0577778 |
| DDX52 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 | 0.0570012 |
| MT1X | metallothionein 1X | 0.0564431 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0554662 |
| SPAG9 | sperm associated antigen 9 | 0.0553255 |
| CALR | calreticulin | 0.0545802 |
| ACTG1 | actin gamma 1 | 0.05419 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0510369 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0510338 |
| CCNY | cyclin Y | 0.0501101 |
| UBC | ubiquitin C | 0.0500037 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.049806 |
| HLA-A | major histocompatibility complex, class I, A | 0.0491225 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0488176 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0487448 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0475247 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0467958 |
| MATR3 | matrin 3 | 0.0463291 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0459763 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0443708 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0437921 |
| HLA-C | major histocompatibility complex, class I, C | 0.0436623 |
| YTHDC1 | YTH domain containing 1 | 0.0435214 |
| TXNIP | thioredoxin interacting protein | 0.0424536 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0423295 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0416669 |
| TOP1 | topoisomerase (DNA) I | 0.0413779 |
| MCL1 | myeloid cell leukemia 1 | 0.0406421 |
| PNN | pinin, desmosome associated protein | 0.0402913 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0401928 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0401216 |
| ARRDC3 | arrestin domain containing 3 | 0.0396887 |
| ADM | adrenomedullin | 0.0389489 |
| TPM3 | tropomyosin 3 | 0.0387779 |
| WIPF2 | WAS/WASL interacting protein family, member 2 | 0.0384931 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0383404 |
| SDC4 | syndecan 4 | 0.0383225 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0382161 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0381115 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0380333 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0380011 |
| MKI67 | marker of proliferation Ki-67 | 0.0377881 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0375214 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0374336 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0371976 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.0365121 |
| RNF149 | ring finger protein 149 | 0.0362013 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0362003 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0361537 |
| EREG | epiregulin | 0.0359128 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0355878 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.03552 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.035343 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.035098 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0349485 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0349443 |
| KLF6 | Kruppel-like factor 6 | 0.0348505 |
| YBX1 | Y box binding protein 1 | 0.034778 |
| WDR45B | WD repeat domain 45B | 0.0346009 |
| YME1L1 | YME1-like 1 ATPase | 0.0345196 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.03451 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0344181 |
| CDC73 | cell division cycle 73 | 0.0339274 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0338381 |
| KRT8 | keratin 8, type II | 0.0335642 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0334481 |
| NUP58 | nucleoporin 58 | 0.0333878 |
| CASC3 | cancer susceptibility candidate 3 | 0.0332017 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MMP7 | matrix metallopeptidase 7 | -0.111615 |
| CP | ceruloplasmin (ferroxidase) | -0.0991526 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0865194 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0668994 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0666219 |
| EFNA5 | ephrin-A5 | -0.0654633 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0645523 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0642472 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0638352 |
| DTNA | dystrobrevin, alpha | -0.0631758 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0630639 |
| RAD51B | RAD51 paralog B | -0.0590127 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0518675 |
| NRG3 | neuregulin 3 | -0.0513925 |
| PARD3 | par-3 family cell polarity regulator | -0.0482911 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0482868 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0467179 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0445169 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0415487 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0409655 |
| EHBP1 | EH domain binding protein 1 | -0.040056 |
| RPL35A | ribosomal protein L35a | -0.0386889 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0385284 |
| KRT19 | keratin 19, type I | -0.0383739 |
| S100A6 | S100 calcium binding protein A6 | -0.0383043 |
| ASPH | aspartate beta-hydroxylase | -0.0376781 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0374196 |
| PLAT | plasminogen activator, tissue | -0.0373147 |
| PCDH7 | protocadherin 7 | -0.0361901 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0358022 |
| RPL34 | ribosomal protein L34 | -0.0357782 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0348456 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0348162 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0343595 |
| INTS6 | integrator complex subunit 6 | -0.0335183 |
| EGR1 | early growth response 1 | -0.0331059 |
| PRKCA | protein kinase C, alpha | -0.0325844 |
| HMGA2 | high mobility group AT-hook 2 | -0.0321939 |
| ATXN1 | ataxin 1 | -0.0318337 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0310303 |
| NCKAP5 | NCK-associated protein 5 | -0.0307999 |
| S100A10 | S100 calcium binding protein A10 | -0.0304896 |
| CMIP | c-Maf inducing protein | -0.0292313 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0290434 |
| TMC5 | transmembrane channel-like 5 | -0.0290368 |
| NABP1 | nucleic acid binding protein 1 | -0.0277639 |
| EGFR | epidermal growth factor receptor | -0.0274349 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0260087 |
| RASAL2 | RAS protein activator like 2 | -0.0259791 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0259418 |
| HMGA1 | high mobility group AT-hook 1 | -0.0257887 |
| S100P | S100 calcium binding protein P | -0.0257492 |
| VIM | vimentin | -0.0251455 |
| RPS29 | ribosomal protein S29 | -0.0250857 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0248569 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0248011 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0244312 |
| LCN2 | lipocalin 2 | -0.0242216 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.02399 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0239067 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0238955 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0238003 |
| RAI14 | retinoic acid induced 14 | -0.0237702 |
| VCL | vinculin | -0.0236332 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0236081 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0235851 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0235543 |
| SVIL | supervillin | -0.0234074 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0232732 |
| ITGA6 | integrin, alpha 6 | -0.0231769 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0231296 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.02291 |
| RPLP1 | ribosomal protein, large, P1 | -0.0227295 |
| GLIS3 | GLIS family zinc finger 3 | -0.0227257 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0226197 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0225681 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0225313 |
| LMO7 | LIM domain 7 | -0.0217324 |
| EXOC4 | exocyst complex component 4 | -0.0216295 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0213605 |
| RPL31 | ribosomal protein L31 | -0.021341 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.021314 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0213033 |
| MYO1E | myosin IE | -0.0205409 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0204919 |
| DNAH11 | dynein, axonemal, heavy chain 11 | -0.0203172 |
| SMYD3 | SET and MYND domain containing 3 | -0.0201355 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0200866 |
| NRG1 | neuregulin 1 | -0.019954 |
| NUMB | numb homolog (Drosophila) | -0.0197521 |
| FBXO11 | F-box protein 11 | -0.0194917 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0194328 |
| ST8SIA6 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 | -0.0189518 |
| RCOR1 | REST corepressor 1 | -0.0189288 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0188908 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0185404 |
| TJP1 | tight junction protein 1 | -0.0185101 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0184812 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0183571 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0182047 |
