Topotecan (hydrochloride)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Topotecan (hydrochloride) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Topotecan (hydrochloride)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.0550636
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0540772
SEPTIN9 septin 9 0.0520243
FAM13A family with sequence similarity 13, member A 0.0482171
MEF2A myocyte enhancer factor 2A 0.0460876
TRIO trio Rho guanine nucleotide exchange factor 0.0456263
PDE4D phosphodiesterase 4D, cAMP-specific 0.0444878
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0442058
NRG1 neuregulin 1 0.044161
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0409937
NALF1 NALCN channel auxiliary factor 1 0.0366805
CDH10 cadherin 10, type 2 (T2-cadherin) 0.035957
ZNF148 zinc finger protein 148 0.0356001
SOS1 son of sevenless homolog 1 (Drosophila) 0.0354202
LIMCH1 LIM and calponin homology domains 1 0.033402
TBX2 T-box 2 0.0328555
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0325848
CEMIP cell migration inducing protein, hyaluronan binding 0.0321088
AKAP12 A kinase (PRKA) anchor protein 12 0.0306288
SLITRK6 SLIT and NTRK-like family, member 6 0.030179
NREP neuronal regeneration related protein 0.0294105
FNDC3B fibronectin type III domain containing 3B 0.0293264
NFE2L1 nuclear factor, erythroid 2-like 1 0.0288798
ITPRID2 ITPR interacting domain containing 2 0.0274098
SCG2 secretogranin II 0.0273582
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0265298
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0258386
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0255174
SETD5 SET domain containing 5 0.0245304
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0239474
SPTBN1 spectrin, beta, non-erythrocytic 1 0.023814
CD46 CD46 molecule, complement regulatory protein 0.0235611
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0234952
FDXR ferredoxin reductase 0.0232354
PTEN phosphatase and tensin homolog 0.0229603
RPL3 ribosomal protein L3 0.0229269
CD36 CD36 molecule (thrombospondin receptor) 0.022924
NBAS neuroblastoma amplified sequence 0.0228946
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0228602
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0226794
DPH6 diphthamine biosynthesis 6 0.0222598
IGFBP3 insulin-like growth factor binding protein 3 0.0221736
RPL21 ribosomal protein L21 0.0220339
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.0220217
FLT1 fms-related tyrosine kinase 1 0.0220122
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.02196
SYTL3 synaptotagmin-like 3 0.0215136
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.021161
FRMD6 FERM domain containing 6 0.0210714
TCERG1 transcription elongation regulator 1 0.0209997
CSNK1D casein kinase 1, delta 0.0209391
LINGO2 leucine rich repeat and Ig domain containing 2 0.0209201
KCNT2 potassium channel, sodium activated subfamily T, member 2 0.0208141
SSBP3 single stranded DNA binding protein 3 0.0207595
PTPRE protein tyrosine phosphatase, receptor type, E 0.0204126
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0203235
HDGF hepatoma-derived growth factor 0.0202035
PFKP phosphofructokinase, platelet 0.0200915
KCTD3 potassium channel tetramerization domain containing 3 0.0199838
DNMBP dynamin binding protein 0.0197395
ATRNL1 attractin-like 1 0.0196602
GPC5 glypican 5 0.0195539
NGLY1 N-glycanase 1 0.019546
RPL37A ribosomal protein L37a 0.0194679
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.0192634
MACF1 microtubule-actin crosslinking factor 1 0.0189696
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0189235
CCNL1 cyclin L1 0.0187515
C1D C1D nuclear receptor corepressor 0.0184424
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0179659
ARHGAP9 Rho GTPase activating protein 9 0.0177834
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0177444
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 0.0176561
PNN pinin, desmosome associated protein 0.0171439
MTSS2 MTSS I-BAR domain containing 2 0.0171011
AHR aryl hydrocarbon receptor 0.016968
ZNF326 zinc finger protein 326 0.0168281
STC1 stanniocalcin 1 0.0168038
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0167135
COL18A1 collagen, type XVIII, alpha 1 0.0163672
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.0163465
SPAG16 sperm associated antigen 16 0.016321
DCAF7 DDB1 and CUL4 associated factor 7 0.0162275
IGFBP5 insulin-like growth factor binding protein 5 0.0161806
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.016091
NCOR2 nuclear receptor corepressor 2 0.0160558
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.0160376
ATP13A3 ATPase type 13A3 0.0160277
ZNF652 zinc finger protein 652 0.0160025
SNX13 sorting nexin 13 0.0159581
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0158923
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0158703
MEGF9 multiple EGF-like-domains 9 0.0158022
CHD3 chromodomain helicase DNA binding protein 3 0.0157628
ZFP36 ZFP36 ring finger protein 0.0153269
DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5 0.0152838
TPM3 tropomyosin 3 0.0152784
CNOT8 CCR4-NOT transcription complex, subunit 8 0.0152742
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 0.0152606
CSNK1A1 casein kinase 1, alpha 1 0.015136

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.294976
VCL vinculin -0.230469
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.16261
VIM vimentin -0.153615
TLE4 transducin-like enhancer of split 4 -0.123619
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.115675
IGF2 insulin-like growth factor 2 -0.112675
FMN1 formin 1 -0.101577
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0965364
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0935195
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0779145
EXT1 exostosin glycosyltransferase 1 -0.0738122
EGR1 early growth response 1 -0.0692631
RPL23 ribosomal protein L23 -0.0682408
IER3 immediate early response 3 -0.0672884
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0670476
RPL34 ribosomal protein L34 -0.0670018
TPT1 tumor protein, translationally-controlled 1 -0.0665524
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.065405
MED13 mediator complex subunit 13 -0.0650974
PTMA prothymosin, alpha -0.064618
RPLP1 ribosomal protein, large, P1 -0.0645956
ACTG1 actin gamma 1 -0.0637049
EIF1 eukaryotic translation initiation factor 1 -0.0585225
CEP350 centrosomal protein 350kDa -0.0574887
UBC ubiquitin C -0.0568049
RPS27A ribosomal protein S27a -0.0564802
RPL19 ribosomal protein L19 -0.0558185
RPL35A ribosomal protein L35a -0.0551591
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0529483
TPM1 tropomyosin 1 (alpha) -0.0527877
VMP1 vacuole membrane protein 1 -0.0524224
TMSB10 thymosin beta 10 -0.0517275
SPAG9 sperm associated antigen 9 -0.0516184
AHNAK AHNAK nucleoprotein -0.0505964
RPS24 ribosomal protein S24 -0.0504429
S100A6 S100 calcium binding protein A6 -0.0504011
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0503428
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0501216
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0500966
COL1A1 collagen, type I, alpha 1 -0.0500261
MYO1E myosin IE -0.0499715
HMGB2 high mobility group box 2 -0.0495549
SLIT2 slit homolog 2 (Drosophila) -0.0491871
KDM3A lysine (K)-specific demethylase 3A -0.0480096
COL3A1 collagen, type III, alpha 1 -0.0470292
FTL ferritin, light polypeptide -0.0468645
CANX calnexin -0.0463302
LMNA lamin A/C -0.0431602
DSCAM Down syndrome cell adhesion molecule -0.0406669
SYT1 synaptotagmin I -0.0403536
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0400978
FNDC3A fibronectin type III domain containing 3A -0.0398973
LOC112694756 uncharaterized LOC112694756 -0.0386879
FERMT2 fermitin family member 2 -0.0385119
TPM4 tropomyosin 4 -0.038261
THBS1 thrombospondin 1 -0.0382274
TNRC6B trinucleotide repeat containing 6B -0.0381416
ANXA2 annexin A2 -0.0380428
IARS1 isoleucyl-tRNA synthetase 1 -0.0367178
CCDC47 coiled-coil domain containing 47 -0.0362565
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0359348
MBD5 methyl-CpG binding domain protein 5 -0.0359096
RPL31 ribosomal protein L31 -0.0356322
CDK12 cyclin-dependent kinase 12 -0.0355793
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0350264
INTS6 integrator complex subunit 6 -0.034886
RACK1 receptor for activated C kinase 1 -0.0348205
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0347176
CALU calumenin -0.0345742
RPLP0 ribosomal protein, large, P0 -0.0345653
HDLBP high density lipoprotein binding protein -0.0344737
STK38L serine/threonine kinase 38 like -0.0344639
ARF1 ADP-ribosylation factor 1 -0.0344034
AFF4 AF4/FMR2 family, member 4 -0.0343804
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0343081
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0342128
GLCCI1 glucocorticoid induced 1 -0.0342018
HIP1 huntingtin interacting protein 1 -0.0340237
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0333917
PRKCA protein kinase C, alpha -0.0331987
RAB1A RAB1A, member RAS oncogene family -0.0324418
SQSTM1 sequestosome 1 -0.0323314
OGA O-GlcNAcase -0.0323276
RIOK3 RIO kinase 3 -0.0312554
PARD3 par-3 family cell polarity regulator -0.0310229
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0310028
RAB7A RAB7A, member RAS oncogene family -0.0307244
PDLIM5 PDZ and LIM domain 5 -0.0306543
KPNB1 karyopherin (importin) beta 1 -0.0306288
PDIA3 protein disulfide isomerase family A, member 3 -0.030595
NCAM2 neural cell adhesion molecule 2 -0.0304111
FBXO11 F-box protein 11 -0.0303489
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0301584
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0299433
NIPBL Nipped-B homolog (Drosophila) -0.0298899
LIMA1 LIM domain and actin binding 1 -0.0297083
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0296939
ENO1 enolase 1, (alpha) -0.0296057
RIGI RNA sensor RIG-I -0.0295987