| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| B2M | beta-2-microglobulin | 0.133065 |
| HLA-B | major histocompatibility complex, class I, B | 0.106767 |
| CALR | calreticulin | 0.106631 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0745515 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0716212 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0709054 |
| PTMA | prothymosin, alpha | 0.0680723 |
| MLPH | melanophilin | 0.063191 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0622247 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.0571963 |
| HLA-C | major histocompatibility complex, class I, C | 0.0563725 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0534922 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0522344 |
| MUC13 | mucin 13, cell surface associated | 0.0514829 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0513484 |
| TRERF1 | transcriptional regulating factor 1 | 0.0511045 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0510366 |
| LCN2 | lipocalin 2 | 0.0504897 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0503648 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0503122 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0501138 |
| VEGFA | vascular endothelial growth factor A | 0.0498914 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.047338 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0466655 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | 0.0465027 |
| TMSB4X | thymosin beta 4, X-linked | 0.0454351 |
| MPHOSPH8 | M-phase phosphoprotein 8 | 0.0452249 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | 0.045135 |
| CMIP | c-Maf inducing protein | 0.0448045 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0443666 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0438058 |
| APOL1 | apolipoprotein L, 1 | 0.043026 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0424149 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0423653 |
| ZC3H13 | zinc finger CCCH-type containing 13 | 0.0423544 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0417536 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0417256 |
| SFTPA2 | surfactant protein A2 | 0.0414014 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0410828 |
| HLA-A | major histocompatibility complex, class I, A | 0.0403138 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | 0.0397932 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.0385052 |
| CDK5RAP3 | CDK5 regulatory subunit associated protein 3 | 0.0384086 |
| KIF16B | kinesin family member 16B | 0.0380796 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 0.037954 |
| PADI1 | peptidyl arginine deiminase, type I | 0.0375077 |
| STYXL2 | serine/threonine/tyrosine interacting like 2 | 0.0373996 |
| ARHGEF10L | Rho guanine nucleotide exchange factor (GEF) 10-like | 0.0371342 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0369425 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0362559 |
| OARD1 | O-acyl-ADP-ribose deacylase 1 | 0.0362212 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0361615 |
| GSDMB | gasdermin B | 0.0358625 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0356366 |
| SMAD3 | SMAD family member 3 | 0.0344487 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0343218 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | 0.0341932 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0337503 |
| ADAR | adenosine deaminase, RNA-specific | 0.0337145 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0327208 |
| RPL7A | ribosomal protein L7a | 0.0323739 |
| RNF213 | ring finger protein 213 | 0.0323067 |
| TSPAN3 | tetraspanin 3 | 0.0321515 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.031712 |
| MUC20 | mucin 20, cell surface associated | 0.0315258 |
| ZNF148 | zinc finger protein 148 | 0.0309068 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | 0.0307514 |
| SH3PXD2A | SH3 and PX domains 2A | 0.0307313 |
| CHD3 | chromodomain helicase DNA binding protein 3 | 0.0300667 |
| RRM2 | ribonucleotide reductase M2 | 0.0299659 |
| TPCN1 | two pore segment channel 1 | 0.0299349 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0298929 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.0297505 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.029716 |
| CGN | cingulin | 0.0294301 |
| LYZ | lysozyme | 0.0292543 |
| COPG1 | coatomer protein complex, subunit gamma 1 | 0.0287568 |
| GOLGA2 | golgin A2 | 0.0286571 |
| APOL2 | apolipoprotein L, 2 | 0.028509 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0284805 |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 0.028425 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0283782 |
| TBPL1 | TBP-like 1 | 0.0282275 |
| MYO10 | myosin X | 0.0282199 |
| UBAC2 | UBA domain containing 2 | 0.0280429 |
| HELZ | helicase with zinc finger | 0.0276521 |
| PFKP | phosphofructokinase, platelet | 0.0273869 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0273832 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0271718 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0271663 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0268778 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.026875 |
| RPL37A | ribosomal protein L37a | 0.0268495 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0268134 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0267182 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0265363 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0263228 |
| RPL23 | ribosomal protein L23 | 0.0263066 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0259243 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.025853 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MACC1 | metastasis associated in colon cancer 1 | -0.12512 |
| VCL | vinculin | -0.103832 |
| MYO1E | myosin IE | -0.10014 |
| LMO7 | LIM domain 7 | -0.0960327 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0872056 |
| EGR1 | early growth response 1 | -0.0752886 |
| NCKAP5 | NCK-associated protein 5 | -0.0745491 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0742524 |
| TJP1 | tight junction protein 1 | -0.0714583 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0690337 |
| EZR | ezrin | -0.0675747 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0633219 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.063046 |
| VMP1 | vacuole membrane protein 1 | -0.059286 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0543147 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0533036 |
| AREG | amphiregulin | -0.0529857 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0483994 |
| PLSCR1 | phospholipid scramblase 1 | -0.0483518 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0477523 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0477017 |
| EFNB2 | ephrin-B2 | -0.0473592 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0459612 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0440356 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0433168 |
| ASPH | aspartate beta-hydroxylase | -0.0432183 |
| RUNX1 | runt-related transcription factor 1 | -0.0427603 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0408997 |
| RIGI | RNA sensor RIG-I | -0.0400939 |
| SPATA13 | spermatogenesis associated 13 | -0.0394828 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0394572 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.039392 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.039238 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0387867 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0387539 |
| PERP | PERP, TP53 apoptosis effector | -0.0385579 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0367247 |
| SP100 | SP100 nuclear antigen | -0.0353275 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.035139 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0351384 |
| ANXA2 | annexin A2 | -0.0351166 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0350238 |
| FHIT | fragile histidine triad | -0.0350105 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0348027 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0346351 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0341939 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0340551 |
| ABLIM1 | actin binding LIM protein 1 | -0.0338875 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0332922 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0324942 |
| INTS6 | integrator complex subunit 6 | -0.0317406 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0310246 |
| EPHB2 | EPH receptor B2 | -0.0306162 |
| XAF1 | XIAP associated factor 1 | -0.030482 |
| FOXP1 | forkhead box P1 | -0.0298209 |
| ITGA6 | integrin, alpha 6 | -0.0292481 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.0290964 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0283732 |
| SQSTM1 | sequestosome 1 | -0.0282677 |
| SBF2 | SET binding factor 2 | -0.0282408 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0280389 |
| TMEM62 | transmembrane protein 62 | -0.0280043 |
| WWOX | WW domain containing oxidoreductase | -0.0279192 |
| NF1 | neurofibromin 1 | -0.027729 |
| EREG | epiregulin | -0.027401 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.026807 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0266111 |
| DIAPH2 | diaphanous-related formin 2 | -0.0265093 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0263031 |
| STK24 | serine/threonine kinase 24 | -0.0260038 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0258093 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0257749 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0257348 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | -0.0256827 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0254694 |
| EXOC4 | exocyst complex component 4 | -0.0252333 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0251621 |
| TSC22D2 | TSC22 domain family, member 2 | -0.024945 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.024913 |
| KLF6 | Kruppel-like factor 6 | -0.0246365 |
| MEIS2 | Meis homeobox 2 | -0.0246358 |
| S100A10 | S100 calcium binding protein A10 | -0.0243583 |
| JUN | jun proto-oncogene | -0.024262 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0242466 |
| DSTN | destrin (actin depolymerizing factor) | -0.0242122 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0240815 |
| RPL7L1 | ribosomal protein L7-like 1 | -0.0240795 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0238861 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0238571 |
| NABP1 | nucleic acid binding protein 1 | -0.0238264 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0235927 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0235923 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0233591 |
| RDH10 | retinol dehydrogenase 10 (all-trans) | -0.0230537 |
| MACROD2 | MACRO domain containing 2 | -0.0229706 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0228072 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0225604 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0223017 |
| FHL2 | four and a half LIM domains 2 | -0.0221006 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0220948 |
