| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.166856 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.153007 |
| FAM13A | family with sequence similarity 13, member A | 0.116793 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0967975 |
| EGFR | epidermal growth factor receptor | 0.0919102 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0896751 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0850077 |
| CADM1 | cell adhesion molecule 1 | 0.0792027 |
| CALR | calreticulin | 0.0674833 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0672296 |
| SETD5 | SET domain containing 5 | 0.0671857 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0655992 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.059154 |
| VEGFA | vascular endothelial growth factor A | 0.0588529 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0544548 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0519188 |
| ZNF395 | zinc finger protein 395 | 0.0510377 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0499038 |
| MMP12 | matrix metallopeptidase 12 | 0.0452078 |
| HELZ | helicase with zinc finger | 0.0417327 |
| ATP13A3 | ATPase type 13A3 | 0.0411795 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0406546 |
| GDF15 | growth differentiation factor 15 | 0.0397231 |
| FN1 | fibronectin 1 | 0.0397137 |
| OGA | O-GlcNAcase | 0.0395922 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0387119 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0375369 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0373955 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0369522 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0365576 |
| ZNF841 | zinc finger protein 841 | 0.0360267 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0348802 |
| LRRC49 | leucine rich repeat containing 49 | 0.0347168 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0347061 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0347004 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0345309 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0329868 |
| GOLGA4 | golgin A4 | 0.0329064 |
| RPLP2 | ribosomal protein, large, P2 | 0.0318314 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0305504 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0305145 |
| RNF145 | ring finger protein 145 | 0.0304402 |
| CD109 | CD109 molecule | 0.0304332 |
| TP53BP1 | tumor protein p53 binding protein 1 | 0.030214 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0301746 |
| FLNB | filamin B, beta | 0.0300654 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0300484 |
| CCNL1 | cyclin L1 | 0.0299289 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0298267 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0298188 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0295504 |
| RAI1 | retinoic acid induced 1 | 0.0292647 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0286306 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | 0.0284684 |
| CDC27 | cell division cycle 27 | 0.0281785 |
| TMEM41B | transmembrane protein 41B | 0.0272069 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0270332 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0270016 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0268617 |
| RPL7A | ribosomal protein L7a | 0.0263155 |
| NUP58 | nucleoporin 58 | 0.0260747 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0260088 |
| VIM | vimentin | 0.0259873 |
| INSIG2 | insulin induced gene 2 | 0.0259814 |
| SNX13 | sorting nexin 13 | 0.0259634 |
| WDR26 | WD repeat domain 26 | 0.0258566 |
| MEF2A | myocyte enhancer factor 2A | 0.025269 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0252658 |
| SBF2 | SET binding factor 2 | 0.0250858 |
| RRBP1 | ribosome binding protein 1 | 0.0250583 |
| PLIN2 | perilipin 2 | 0.0250397 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0249734 |
| TNS3 | tensin 3 | 0.0248792 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0247794 |
| USP47 | ubiquitin specific peptidase 47 | 0.0245921 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0243252 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0242538 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.023976 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0239169 |
| SEC63 | SEC63 homolog (S. cerevisiae) | 0.023899 |
| CD47 | CD47 molecule | 0.0237338 |
| SMAD3 | SMAD family member 3 | 0.0236612 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0236463 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0235754 |
| LOXL2 | lysyl oxidase-like 2 | 0.0234823 |
| GOLGA2 | golgin A2 | 0.0233738 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0232587 |
| MYOF | myoferlin | 0.0232519 |
| TMEM39A | transmembrane protein 39A | 0.023105 |
| PTMA | prothymosin, alpha | 0.0230297 |
| TBC1D23 | TBC1 domain family, member 23 | 0.0229369 |
| RASA2 | RAS p21 protein activator 2 | 0.0229367 |
| USP3 | ubiquitin specific peptidase 3 | 0.0228449 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0227021 |
| SRP54 | signal recognition particle 54kDa | 0.0222908 |
| ZC3H15 | zinc finger CCCH-type containing 15 | 0.022143 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0220956 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0218419 |
| ANXA2 | annexin A2 | 0.0216801 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0216404 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.299652 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.199897 |
| FTL | ferritin, light polypeptide | -0.156009 |
| ASPH | aspartate beta-hydroxylase | -0.117536 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.109416 |
| KYNU | kynureninase | -0.0962325 |
| NLGN1 | neuroligin 1 | -0.0927951 |
| CD44 | CD44 molecule (Indian blood group) | -0.0905393 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0896228 |
| MT2A | metallothionein 2A | -0.0891698 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0861193 |
| LOC112694756 | uncharaterized LOC112694756 | -0.068118 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0666932 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0644949 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0622763 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0609699 |
| EGR1 | early growth response 1 | -0.0608001 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0579152 |
| TXNRD1 | thioredoxin reductase 1 | -0.057635 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0551595 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0514569 |
| PHF14 | PHD finger protein 14 | -0.0492186 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0486391 |
| RPLP1 | ribosomal protein, large, P1 | -0.0482061 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0456947 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0433739 |
| RPLP0 | ribosomal protein, large, P0 | -0.0433607 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0416021 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0409944 |
| INTS6 | integrator complex subunit 6 | -0.0409886 |
| TMSB10 | thymosin beta 10 | -0.0408235 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0401793 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.03967 |
| LDHA | lactate dehydrogenase A | -0.0387823 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0382239 |
| LOX | lysyl oxidase | -0.0378366 |
| VCL | vinculin | -0.0377766 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0377123 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0373895 |
| DTNA | dystrobrevin, alpha | -0.0372222 |
| NAV3 | neuron navigator 3 | -0.0371171 |
| CALN1 | calneuron 1 | -0.0368248 |
| RPL28 | ribosomal protein L28 | -0.0366352 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0362746 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0361033 |
| SP100 | SP100 nuclear antigen | -0.0356462 |
| TENM3 | teneurin transmembrane protein 3 | -0.0354564 |
| AUTS2 | autism susceptibility candidate 2 | -0.0353579 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0348255 |
| WWOX | WW domain containing oxidoreductase | -0.0344248 |
| APP | amyloid beta (A4) precursor protein | -0.0339411 |
| UBAP2 | ubiquitin associated protein 2 | -0.0335892 |
| GLIS3 | GLIS family zinc finger 3 | -0.0334051 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0323338 |
| GNG12 | guanine nucleotide binding protein (G protein), gamma 12 | -0.0322179 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | -0.0316001 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0315907 |
| ATXN1 | ataxin 1 | -0.0314674 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0312518 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0312327 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0310947 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0309572 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0308784 |
| GPHN | gephyrin | -0.0307186 |
| GRAMD1B | GRAM domain containing 1B | -0.0304328 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0303946 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0302226 |
| CDK14 | cyclin-dependent kinase 14 | -0.0301309 |
| RUNX1 | runt-related transcription factor 1 | -0.0297845 |
| ARF1 | ADP-ribosylation factor 1 | -0.029475 |
| MT1X | metallothionein 1X | -0.0294399 |
| POTEF | POTE ankyrin domain family, member F | -0.0293534 |
| TPTE | transmembrane phosphatase with tensin homology | -0.0285898 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0285896 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0284272 |
| FGF13 | fibroblast growth factor 13 | -0.0281938 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0280851 |
| GLCCI1 | glucocorticoid induced 1 | -0.0279168 |
| NRXN3 | neurexin 3 | -0.0274675 |
| PTK2 | protein tyrosine kinase 2 | -0.0274318 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0271649 |
| RNF216 | ring finger protein 216 | -0.0270452 |
| ACTN1 | actinin, alpha 1 | -0.0270322 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0269155 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0264357 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0263586 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0262401 |
| HDAC9 | histone deacetylase 9 | -0.0261167 |
| RPL27A | ribosomal protein L27a | -0.0251363 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | -0.0251045 |
| PKM | pyruvate kinase, muscle | -0.0247667 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0246975 |
| AHRR | aryl-hydrocarbon receptor repressor | -0.0244051 |
| MYO10 | myosin X | -0.0242606 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0241657 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0240423 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.0240198 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0239397 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.023915 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0237969 |
