| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.218755 |
| GOLGA4 | golgin A4 | 0.0903452 |
| ZNF292 | zinc finger protein 292 | 0.0798582 |
| SETD5 | SET domain containing 5 | 0.0729604 |
| HELZ | helicase with zinc finger | 0.0672581 |
| TMF1 | TATA element modulatory factor 1 | 0.0666192 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0654366 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0647863 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0624066 |
| YEATS2 | YEATS domain containing 2 | 0.0612528 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0600534 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0539841 |
| GOLGB1 | golgin B1 | 0.0536247 |
| RPL37A | ribosomal protein L37a | 0.0529737 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0517978 |
| VEGFA | vascular endothelial growth factor A | 0.0512977 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0499289 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0485938 |
| VMP1 | vacuole membrane protein 1 | 0.047917 |
| MCL1 | myeloid cell leukemia 1 | 0.0474183 |
| PCBP2 | poly(rC) binding protein 2 | 0.0470252 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0465658 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0464318 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0458343 |
| WDR26 | WD repeat domain 26 | 0.0454845 |
| CCNL1 | cyclin L1 | 0.0452388 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0443327 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0442241 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0435107 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0435041 |
| RPS2 | ribosomal protein S2 | 0.0419498 |
| TMEM41B | transmembrane protein 41B | 0.0418844 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0413704 |
| NUP58 | nucleoporin 58 | 0.0403665 |
| TPR | translocated promoter region, nuclear basket protein | 0.0403388 |
| SUCO | SUN domain containing ossification factor | 0.0399373 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0398078 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0394212 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0386607 |
| COG6 | component of oligomeric golgi complex 6 | 0.0383348 |
| ARF4 | ADP-ribosylation factor 4 | 0.0382897 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0382823 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0375245 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0373857 |
| CDK19 | cyclin-dependent kinase 19 | 0.0371278 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0370385 |
| RBM5 | RNA binding motif protein 5 | 0.0364067 |
| TMEM39A | transmembrane protein 39A | 0.0363731 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0362456 |
| RPS12 | ribosomal protein S12 | 0.0361413 |
| OGA | O-GlcNAcase | 0.0354621 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0351315 |
| RNF24 | ring finger protein 24 | 0.0349681 |
| PRELID2 | PRELI domain containing 2 | 0.0348867 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0347625 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.03468 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0342568 |
| DSPP | dentin sialophosphoprotein | 0.0342152 |
| EP300 | E1A binding protein p300 | 0.0341569 |
| PRRC2C | proline-rich coiled-coil 2C | 0.034077 |
| MT2A | metallothionein 2A | 0.0340764 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0338779 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0337475 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0335733 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.033551 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0335088 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0333727 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0333373 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.033247 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0328722 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0325616 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.032502 |
| RRM2 | ribonucleotide reductase M2 | 0.0323938 |
| SMAD4 | SMAD family member 4 | 0.032182 |
| CEP95 | centrosomal protein 95kDa | 0.0320895 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0317499 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.031281 |
| RPS6 | ribosomal protein S6 | 0.0312776 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0311653 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0311433 |
| THOC2 | THO complex 2 | 0.0310062 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0307001 |
| INSIG2 | insulin induced gene 2 | 0.0306795 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0304014 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0302419 |
| PNN | pinin, desmosome associated protein | 0.0300027 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.029958 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0298095 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0297962 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0297784 |
| RPL7A | ribosomal protein L7a | 0.0295481 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0294734 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0294643 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0292383 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0291025 |
| MKI67 | marker of proliferation Ki-67 | 0.0287189 |
| SEC24A | SEC24 family member A | 0.0286387 |
| RCOR1 | REST corepressor 1 | 0.0286023 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0285655 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0281985 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.30129 |
| FAT1 | FAT atypical cadherin 1 | -0.197516 |
| AHNAK | AHNAK nucleoprotein | -0.192641 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.173273 |
| LOC112694756 | uncharaterized LOC112694756 | -0.145421 |
| TMSB10 | thymosin beta 10 | -0.0837657 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0812128 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0678344 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0666494 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0607471 |
| NDRG1 | N-myc downstream regulated 1 | -0.0586072 |
| ARF1 | ADP-ribosylation factor 1 | -0.0560034 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0534209 |
| RPLP0 | ribosomal protein, large, P0 | -0.0533557 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0510226 |
| CANX | calnexin | -0.0506865 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0492316 |
| RPL35A | ribosomal protein L35a | -0.0460938 |
| FHIT | fragile histidine triad | -0.045518 |
| LDHA | lactate dehydrogenase A | -0.044651 |
| HDLBP | high density lipoprotein binding protein | -0.0441245 |
| INTS6 | integrator complex subunit 6 | -0.03984 |
| CCND1 | cyclin D1 | -0.0389604 |
| RPLP1 | ribosomal protein, large, P1 | -0.0387719 |
| FTL | ferritin, light polypeptide | -0.0385905 |
| PTMA | prothymosin, alpha | -0.0378953 |
| H1-0 | H1.0 linker histone | -0.0370362 |
| MSI2 | musashi RNA-binding protein 2 | -0.0368822 |
| RPL34 | ribosomal protein L34 | -0.0352473 |
| S100A10 | S100 calcium binding protein A10 | -0.0347859 |
| TENM3 | teneurin transmembrane protein 3 | -0.0340965 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0337803 |
| ENO1 | enolase 1, (alpha) | -0.0329277 |
| FRMD5 | FERM domain containing 5 | -0.0327077 |
| WWOX | WW domain containing oxidoreductase | -0.0323861 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0321376 |
| KRT18 | keratin 18, type I | -0.0316546 |
| RPS24 | ribosomal protein S24 | -0.0312282 |
| PKM | pyruvate kinase, muscle | -0.0306649 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0304881 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0303144 |
| KRT19 | keratin 19, type I | -0.030248 |
| ZNRF3 | zinc and ring finger 3 | -0.0300754 |
| GPHN | gephyrin | -0.0296284 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0295117 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.029461 |
| FUS | FUS RNA binding protein | -0.0293204 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0286256 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | -0.0280502 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0277331 |
| UBE2I | ubiquitin-conjugating enzyme E2I | -0.0275406 |
| SMYD3 | SET and MYND domain containing 3 | -0.0272801 |
| EZR | ezrin | -0.0268255 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0266137 |
| TKT | transketolase | -0.0264906 |
| RPL4 | ribosomal protein L4 | -0.0262628 |
| LRRC23 | leucine rich repeat containing 23 | -0.0260458 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0254686 |
| R3HDM1 | R3H domain containing 1 | -0.0254286 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0254087 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0250283 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0249564 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0248772 |
| ABLIM1 | actin binding LIM protein 1 | -0.0248503 |
| AGPAT3 | 1-acylglycerol-3-phosphate O-acyltransferase 3 | -0.0247808 |
| PARD3 | par-3 family cell polarity regulator | -0.0246483 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0245007 |
| RNF43 | ring finger protein 43 | -0.0243759 |
| YBX1 | Y box binding protein 1 | -0.0243155 |
| NBEAL1 | neurobeachin-like 1 | -0.0242582 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0241742 |
| HMGA2 | high mobility group AT-hook 2 | -0.0241658 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0239966 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0238178 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.023724 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0235524 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0233291 |
| ANXA2 | annexin A2 | -0.0233042 |
| RPS5 | ribosomal protein S5 | -0.0233016 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0232469 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0231072 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0228866 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0222981 |
| EPCAM | epithelial cell adhesion molecule | -0.0222241 |
| APP | amyloid beta (A4) precursor protein | -0.0222193 |
| RPL14 | ribosomal protein L14 | -0.021868 |
| TMEM123 | transmembrane protein 123 | -0.0216603 |
| HMGB1 | high mobility group box 1 | -0.0215159 |
| PKP4 | plakophilin 4 | -0.0214952 |
| ACTG1 | actin gamma 1 | -0.02147 |
| RTN3 | reticulon 3 | -0.0214196 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0212092 |
| SCFD2 | sec1 family domain containing 2 | -0.0207594 |
| CCDC47 | coiled-coil domain containing 47 | -0.0207283 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0206261 |
| CFAP97 | cilia and flagella associated protein 97 | -0.0203254 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0202311 |
| NPR2 | natriuretic peptide receptor 2 | -0.020159 |
| RACK1 | receptor for activated C kinase 1 | -0.0201576 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0200828 |
