| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB4X | thymosin beta 4, X-linked | 0.153351 |
| APP | amyloid beta (A4) precursor protein | 0.105732 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0909426 |
| FLNA | filamin A, alpha | 0.0890192 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0833422 |
| AHNAK | AHNAK nucleoprotein | 0.0755615 |
| PTMA | prothymosin, alpha | 0.0754925 |
| LAMB3 | laminin, beta 3 | 0.0751226 |
| PLEC | plectin | 0.0711254 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0696075 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0669021 |
| CALR | calreticulin | 0.0667615 |
| ACTG1 | actin gamma 1 | 0.061797 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0600315 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0588676 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0503963 |
| FLNB | filamin B, beta | 0.0471392 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0466675 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.045683 |
| SDC4 | syndecan 4 | 0.0443786 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0441267 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0420231 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0413103 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0411928 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0408137 |
| YBX1 | Y box binding protein 1 | 0.0402844 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0392707 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0373215 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0372108 |
| RPN1 | ribophorin I | 0.0357202 |
| ACTN4 | actinin, alpha 4 | 0.0354674 |
| SMAD3 | SMAD family member 3 | 0.035304 |
| RPL7A | ribosomal protein L7a | 0.0347945 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0345362 |
| ANXA2 | annexin A2 | 0.0344858 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.033329 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0321037 |
| RNF213 | ring finger protein 213 | 0.0320227 |
| FUS | FUS RNA binding protein | 0.0312991 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0311943 |
| RPL3 | ribosomal protein L3 | 0.030483 |
| RBM5 | RNA binding motif protein 5 | 0.0300675 |
| LARP1 | La ribonucleoprotein domain family, member 1 | 0.0298676 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.0298142 |
| CCNL1 | cyclin L1 | 0.0295627 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0290301 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0288494 |
| RPL13A | ribosomal protein L13a | 0.0287824 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.028405 |
| YEATS2 | YEATS domain containing 2 | 0.0283882 |
| KRT7 | keratin 7, type II | 0.0281712 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0280782 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0279984 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0278229 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0277595 |
| FMNL2 | formin-like 2 | 0.0275626 |
| CHD3 | chromodomain helicase DNA binding protein 3 | 0.0274673 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.0274016 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.027243 |
| CTBP2 | C-terminal binding protein 2 | 0.0262909 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0261639 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.026013 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0258369 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0256979 |
| FAM168A | family with sequence similarity 168, member A | 0.0256367 |
| EMP1 | epithelial membrane protein 1 | 0.0253051 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0252266 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0250884 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0248268 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0248148 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0248126 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0248122 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0247019 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0246841 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0246748 |
| SNRNP70 | small nuclear ribonucleoprotein 70kDa (U1) | 0.0245714 |
| MACROH2A1 | macroH2A.1 histone | 0.0242854 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0242384 |
| CDK5RAP2 | CDK5 regulatory subunit associated protein 2 | 0.0241241 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0241057 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0239957 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.023938 |
| HNRNPUL1 | heterogeneous nuclear ribonucleoprotein U-like 1 | 0.0239058 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0236198 |
| LAMC2 | laminin, gamma 2 | 0.0235839 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0235552 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0235538 |
| VEGFA | vascular endothelial growth factor A | 0.023472 |
| EIF3D | eukaryotic translation initiation factor 3, subunit D | 0.0230688 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0229871 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0229779 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0229384 |
| POU5F1 | POU class 5 homeobox 1 | 0.0229374 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0228537 |
| LASP1 | LIM and SH3 protein 1 | 0.0228281 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0227978 |
| MDN1 | MDN1, midasin homolog (yeast) | 0.0227835 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0227816 |
| TAF7 | TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa | 0.0227024 |
| TJP2 | tight junction protein 2 | 0.0226911 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.215549 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.118513 |
| MACROD2 | MACRO domain containing 2 | -0.0879807 |
| GOLGA4 | golgin A4 | -0.0844735 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0817192 |
| ASPH | aspartate beta-hydroxylase | -0.080287 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0766985 |
| FTL | ferritin, light polypeptide | -0.0760394 |
| MT2A | metallothionein 2A | -0.0746851 |
| ENO1 | enolase 1, (alpha) | -0.0738278 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0714431 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0702525 |
| TXNRD1 | thioredoxin reductase 1 | -0.0674644 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0671191 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0640829 |
| FHIT | fragile histidine triad | -0.0589873 |
| CCND1 | cyclin D1 | -0.0579585 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0579115 |
| SEPTIN7 | septin 7 | -0.0566664 |
| VCL | vinculin | -0.055232 |
| BPTF | bromodomain PHD finger transcription factor | -0.053185 |
| POTEF | POTE ankyrin domain family, member F | -0.052075 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0507413 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0500506 |
| RAD51B | RAD51 paralog B | -0.04864 |
| LDHA | lactate dehydrogenase A | -0.0473256 |
| CDCP1 | CUB domain containing protein 1 | -0.0466519 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0451651 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0449759 |
| PRELID2 | PRELI domain containing 2 | -0.0438246 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0429087 |
| BBX | bobby sox homolog (Drosophila) | -0.0417059 |
| WWOX | WW domain containing oxidoreductase | -0.0416987 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0397667 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0380354 |
| MAP4 | microtubule-associated protein 4 | -0.0375698 |
| DIAPH3 | diaphanous-related formin 3 | -0.0374069 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0373821 |
| SMYD3 | SET and MYND domain containing 3 | -0.03724 |
| NF1 | neurofibromin 1 | -0.037041 |
| DSTN | destrin (actin depolymerizing factor) | -0.0368676 |
| RPL34 | ribosomal protein L34 | -0.0358315 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0356645 |
| S100A10 | S100 calcium binding protein A10 | -0.0356505 |
| SBF2 | SET binding factor 2 | -0.0343925 |
| RPS2 | ribosomal protein S2 | -0.03398 |
| MT1X | metallothionein 1X | -0.0339476 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0335638 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | -0.0329937 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0323748 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.0320724 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0319915 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0315217 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0311607 |
| PKM | pyruvate kinase, muscle | -0.0311092 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0307025 |
| NDRG1 | N-myc downstream regulated 1 | -0.0304279 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.030204 |
| EGR1 | early growth response 1 | -0.030174 |
| RPL11 | ribosomal protein L11 | -0.0300525 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0300276 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0300127 |
| MYO9A | myosin IXA | -0.0297036 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0295915 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0293894 |
| TJP1 | tight junction protein 1 | -0.0290145 |
| RPS19 | ribosomal protein S19 | -0.0288363 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0287906 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0283154 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.027852 |
| TUBA1B | tubulin, alpha 1b | -0.0277102 |
| DEK | DEK proto-oncogene | -0.0276485 |
| RPS12 | ribosomal protein S12 | -0.0275892 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0274419 |
| RPLP1 | ribosomal protein, large, P1 | -0.0273994 |
| SEC24A | SEC24 family member A | -0.0271213 |
| ATXN1 | ataxin 1 | -0.0270684 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0270457 |
| USP34 | ubiquitin specific peptidase 34 | -0.0267949 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0267784 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0266996 |
| VMP1 | vacuole membrane protein 1 | -0.026572 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0261027 |
| PGK1 | phosphoglycerate kinase 1 | -0.0260894 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0260813 |
| KIAA1328 | KIAA1328 | -0.0260578 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0259403 |
| CENPF | centromere protein F, 350/400kDa | -0.025936 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0257242 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.0257005 |
| EXOC4 | exocyst complex component 4 | -0.0255123 |
| SVIL | supervillin | -0.0251475 |
| RPLP0 | ribosomal protein, large, P0 | -0.0250598 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0247596 |
| ANKRD12 | ankyrin repeat domain 12 | -0.024673 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0246607 |
| SUMF1 | sulfatase modifying factor 1 | -0.0245268 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0244423 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0242933 |
| PARD3B | par-3 family cell polarity regulator beta | -0.024168 |
