| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.170502 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.150987 |
| FAM13A | family with sequence similarity 13, member A | 0.150645 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.13964 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.121019 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.103399 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.102217 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0969555 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0844317 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0771776 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0765185 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0713598 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0703576 |
| SETD5 | SET domain containing 5 | 0.0658327 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0648867 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0642271 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0641811 |
| OGA | O-GlcNAcase | 0.0636504 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0602982 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0559803 |
| STC1 | stanniocalcin 1 | 0.0532942 |
| AXL | AXL receptor tyrosine kinase | 0.0529646 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0514125 |
| VEGFA | vascular endothelial growth factor A | 0.0506936 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0500623 |
| RNF145 | ring finger protein 145 | 0.0500377 |
| SEPTIN9 | septin 9 | 0.0486595 |
| RNF24 | ring finger protein 24 | 0.0479641 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0465294 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0462242 |
| NGLY1 | N-glycanase 1 | 0.0458107 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.04573 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0449424 |
| ATP13A3 | ATPase type 13A3 | 0.0442432 |
| MSN | moesin | 0.0436313 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0433044 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0432324 |
| INHBA | inhibin, beta A | 0.0426851 |
| CDCP1 | CUB domain containing protein 1 | 0.041841 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0418288 |
| SET | SET nuclear proto-oncogene | 0.0412858 |
| SMAD3 | SMAD family member 3 | 0.0403561 |
| PTMA | prothymosin, alpha | 0.0397896 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0391143 |
| PTK2 | protein tyrosine kinase 2 | 0.038549 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0382115 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0378525 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0376792 |
| HELZ | helicase with zinc finger | 0.0373423 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0370517 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0369615 |
| CAPRIN2 | caprin family member 2 | 0.0366671 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0361269 |
| ZNF292 | zinc finger protein 292 | 0.0360941 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0360326 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0351951 |
| SPAG9 | sperm associated antigen 9 | 0.0349159 |
| TPM3 | tropomyosin 3 | 0.0346436 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0341961 |
| MATR3 | matrin 3 | 0.0341733 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0339668 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0339356 |
| PGK1 | phosphoglycerate kinase 1 | 0.0336952 |
| H1-4 | H1.4 linker histone, cluster member | 0.0334552 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0333522 |
| NUP58 | nucleoporin 58 | 0.0331404 |
| RRM2 | ribonucleotide reductase M2 | 0.033056 |
| ZNF638 | zinc finger protein 638 | 0.0328635 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0325198 |
| MYO10 | myosin X | 0.0324156 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.032072 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0320082 |
| TXNIP | thioredoxin interacting protein | 0.0317632 |
| H1-2 | H1.2 linker histone, cluster member | 0.0316645 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0315351 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0309484 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0305048 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0300491 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0298893 |
| MKI67 | marker of proliferation Ki-67 | 0.0295333 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0294033 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.02922 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0291866 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0291616 |
| ANXA5 | annexin A5 | 0.0291443 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0290451 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0289644 |
| XPO1 | exportin 1 | 0.0288019 |
| SEPTIN7 | septin 7 | 0.0287916 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0286467 |
| YEATS2 | YEATS domain containing 2 | 0.0283351 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0283149 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0282421 |
| GOLGA4 | golgin A4 | 0.028134 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0281152 |
| RBM25 | RNA binding motif protein 25 | 0.0278793 |
| FNBP1 | formin binding protein 1 | 0.0277287 |
| TPX2 | TPX2, microtubule-associated | 0.0275985 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.027424 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0271297 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.191921 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.19032 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.187749 |
| HMGA2 | high mobility group AT-hook 2 | -0.126485 |
| EGR1 | early growth response 1 | -0.120447 |
| TMSB10 | thymosin beta 10 | -0.0952488 |
| IGF2 | insulin-like growth factor 2 | -0.0829477 |
| LOX | lysyl oxidase | -0.0821293 |
| COL5A1 | collagen, type V, alpha 1 | -0.0709636 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.065204 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0557218 |
| CCND1 | cyclin D1 | -0.0493443 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0452927 |
| FTL | ferritin, light polypeptide | -0.0451828 |
| ACTG1 | actin gamma 1 | -0.0428381 |
| CDH13 | cadherin 13 | -0.0415066 |
| RPLP1 | ribosomal protein, large, P1 | -0.0412576 |
| GLIS3 | GLIS family zinc finger 3 | -0.0381898 |
| TENM2 | teneurin transmembrane protein 2 | -0.0373696 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0362949 |
| CD44 | CD44 molecule (Indian blood group) | -0.0343457 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0338188 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0335283 |
| FMN1 | formin 1 | -0.0330581 |
| IER3 | immediate early response 3 | -0.0314611 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0313766 |
| VCL | vinculin | -0.0294599 |
| RPL35A | ribosomal protein L35a | -0.0277358 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0276384 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0266184 |
| EMP1 | epithelial membrane protein 1 | -0.026074 |
| CAVIN1 | caveolae associated protein 1 | -0.0247219 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0245905 |
| COL1A1 | collagen, type I, alpha 1 | -0.0233851 |
| RPS24 | ribosomal protein S24 | -0.0231071 |
| FLNA | filamin A, alpha | -0.022632 |
| RPLP0 | ribosomal protein, large, P0 | -0.0224986 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0223942 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0223748 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0220357 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0217628 |
| NABP1 | nucleic acid binding protein 1 | -0.0214232 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0210302 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0208198 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0206465 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.020162 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0199474 |
| HMGA1 | high mobility group AT-hook 1 | -0.0194133 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0191907 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0190396 |
| INTS6 | integrator complex subunit 6 | -0.0187477 |
| ARF1 | ADP-ribosylation factor 1 | -0.0183294 |
| THBS2 | thrombospondin 2 | -0.0177843 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0176411 |
| THBS1 | thrombospondin 1 | -0.0175769 |
| CLIC4 | chloride intracellular channel 4 | -0.0174032 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0173575 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0172783 |
| ANXA2 | annexin A2 | -0.0170468 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.016948 |
| ASTN2 | astrotactin 2 | -0.0168656 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0167815 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0167212 |
| POTEF | POTE ankyrin domain family, member F | -0.0166738 |
| HDLBP | high density lipoprotein binding protein | -0.0165236 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0163331 |
| SEC24D | SEC24 family member D | -0.0161016 |
| CALR | calreticulin | -0.0160982 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0160332 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0159639 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0159573 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0157515 |
| PFN1 | profilin 1 | -0.015718 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0157157 |
| LRRC23 | leucine rich repeat containing 23 | -0.015548 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0154296 |
| TNNC1 | troponin C type 1 (slow) | -0.0154077 |
| DIAPH2 | diaphanous-related formin 2 | -0.0151486 |
| ATG7 | autophagy related 7 | -0.0150889 |
| RPL34 | ribosomal protein L34 | -0.0150469 |
| RAI14 | retinoic acid induced 14 | -0.0150412 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0148043 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.014562 |
| ACTN1 | actinin, alpha 1 | -0.0144044 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0144007 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0143637 |
| BSG | basigin (Ok blood group) | -0.0139391 |
| GANAB | glucosidase, alpha; neutral AB | -0.0137401 |
| RPS19 | ribosomal protein S19 | -0.0137383 |
| KLF12 | Kruppel-like factor 12 | -0.0136658 |
| CTSD | cathepsin D | -0.0135761 |
| IRAG2 | inositol 1,4,5-triphosphate receptor associated 2 | -0.0135233 |
| TAGLN2 | transgelin 2 | -0.0132961 |
| L1CAM | L1 cell adhesion molecule | -0.0132897 |
| CDK14 | cyclin-dependent kinase 14 | -0.0132823 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0130806 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0130207 |
| RAB31 | RAB31, member RAS oncogene family | -0.0130114 |
| YBX1 | Y box binding protein 1 | -0.0129239 |
| RPL28 | ribosomal protein L28 | -0.0128936 |
