| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.136256 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.117963 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.116561 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0966703 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0873155 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0872514 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0825324 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0738345 |
| CADM1 | cell adhesion molecule 1 | 0.0714303 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0694417 |
| ATP13A3 | ATPase type 13A3 | 0.0686134 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0672539 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0635465 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0623355 |
| MT2A | metallothionein 2A | 0.0615822 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0592086 |
| AHNAK | AHNAK nucleoprotein | 0.0591791 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.059026 |
| FN1 | fibronectin 1 | 0.0579638 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0559627 |
| ANKRD11 | ankyrin repeat domain 11 | 0.05441 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0535255 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0530488 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.052909 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0484681 |
| FMNL2 | formin-like 2 | 0.0483964 |
| PTK2 | protein tyrosine kinase 2 | 0.0473841 |
| PLEC | plectin | 0.0447647 |
| TMSB4X | thymosin beta 4, X-linked | 0.0442976 |
| SMAD3 | SMAD family member 3 | 0.0441629 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0436469 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0436462 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0432893 |
| IL6ST | interleukin 6 signal transducer | 0.0420459 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0418598 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0416091 |
| APP | amyloid beta (A4) precursor protein | 0.0413247 |
| CANX | calnexin | 0.0397964 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0397387 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0375291 |
| CALR | calreticulin | 0.0368477 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0366152 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0365894 |
| CDH13 | cadherin 13 | 0.0364759 |
| MTSS1 | metastasis suppressor 1 | 0.0359091 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0358158 |
| SQSTM1 | sequestosome 1 | 0.0356852 |
| RUNX1 | runt-related transcription factor 1 | 0.035229 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0347359 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0340918 |
| MRTFA | myocardin related transcription factor A | 0.0339393 |
| STC1 | stanniocalcin 1 | 0.0337028 |
| RIGI | RNA sensor RIG-I | 0.0336182 |
| PRELID2 | PRELI domain containing 2 | 0.0333022 |
| RND3 | Rho family GTPase 3 | 0.0331929 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0321645 |
| MYO10 | myosin X | 0.0321064 |
| ASPH | aspartate beta-hydroxylase | 0.0319682 |
| HIP1 | huntingtin interacting protein 1 | 0.0318726 |
| IER3 | immediate early response 3 | 0.0315607 |
| OGA | O-GlcNAcase | 0.0315382 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0314132 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0313556 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.031045 |
| NAV2 | neuron navigator 2 | 0.0309466 |
| RASA2 | RAS p21 protein activator 2 | 0.0303396 |
| RPS2 | ribosomal protein S2 | 0.0299825 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0298823 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0297048 |
| YEATS2 | YEATS domain containing 2 | 0.0294549 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0292801 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0292561 |
| ZNF292 | zinc finger protein 292 | 0.0290024 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0286503 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0286146 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0281237 |
| EGFR | epidermal growth factor receptor | 0.0277458 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0275726 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0273075 |
| ARRDC3 | arrestin domain containing 3 | 0.0273033 |
| SPAG9 | sperm associated antigen 9 | 0.027228 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0268462 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0267864 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0264745 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0262883 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0258492 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.025504 |
| EFNA5 | ephrin-A5 | 0.025402 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0247147 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0241282 |
| PPP3CC | protein phosphatase 3, catalytic subunit, gamma isozyme | 0.0239523 |
| SDC4 | syndecan 4 | 0.0237718 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0234059 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0233742 |
| LOXL2 | lysyl oxidase-like 2 | 0.0231246 |
| FBXO32 | F-box protein 32 | 0.0230846 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0229994 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0229417 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0225573 |
| H1-4 | H1.4 linker histone, cluster member | 0.0224719 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.468393 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.228763 |
| VIM | vimentin | -0.186067 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.16672 |
| NDRG1 | N-myc downstream regulated 1 | -0.120566 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.103913 |
| COL1A1 | collagen, type I, alpha 1 | -0.103337 |
| COL1A2 | collagen, type I, alpha 2 | -0.0925994 |
| LOX | lysyl oxidase | -0.0775791 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0725863 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0708854 |
| EGR1 | early growth response 1 | -0.0578862 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0534439 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0455165 |
| FTL | ferritin, light polypeptide | -0.0427857 |
| TMSB10 | thymosin beta 10 | -0.0425387 |
| GLIS3 | GLIS family zinc finger 3 | -0.0402275 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0389323 |
| MAP1B | microtubule-associated protein 1B | -0.0341675 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0339098 |
| POSTN | periostin, osteoblast specific factor | -0.0337006 |
| PFN1 | profilin 1 | -0.0329058 |
| TAPBP | TAP binding protein (tapasin) | -0.0314234 |
| FBN1 | fibrillin 1 | -0.0314024 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0312482 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.031206 |
| POTEF | POTE ankyrin domain family, member F | -0.0310654 |
| RPL35A | ribosomal protein L35a | -0.0308317 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0306095 |
| MYADM | myeloid-associated differentiation marker | -0.0294785 |
| HMGA2 | high mobility group AT-hook 2 | -0.0292175 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0270161 |
| BSG | basigin (Ok blood group) | -0.0242142 |
| PKM | pyruvate kinase, muscle | -0.0241887 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0229195 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0226731 |
| HLA-A | major histocompatibility complex, class I, A | -0.0224777 |
| CALD1 | caldesmon 1 | -0.0221951 |
| HMGA1 | high mobility group AT-hook 1 | -0.0219531 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0218399 |
| AXL | AXL receptor tyrosine kinase | -0.021761 |
| PALLD | palladin, cytoskeletal associated protein | -0.0205042 |
| NRP1 | neuropilin 1 | -0.0200263 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0199538 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0198062 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0193274 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0192013 |
| SBF2 | SET binding factor 2 | -0.0190024 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0186702 |
| TAGLN2 | transgelin 2 | -0.0179034 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0172212 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0168798 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0168541 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0166034 |
| WASF2 | WAS protein family, member 2 | -0.0160668 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0157721 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0155335 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0155058 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0153576 |
| LAMA5 | laminin, alpha 5 | -0.015251 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | -0.0145889 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0143037 |
| DSTN | destrin (actin depolymerizing factor) | -0.01416 |
| PLBD2 | phospholipase B domain containing 2 | -0.01372 |
| SMIM44 | small integral membrane protein 44 | -0.0136904 |
| CTSD | cathepsin D | -0.013491 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0131294 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0130639 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0129792 |
| SERP1 | stress-associated endoplasmic reticulum protein 1 | -0.0127339 |
| MYL9 | myosin, light chain 9, regulatory | -0.0127335 |
| CLIC4 | chloride intracellular channel 4 | -0.0126644 |
| ARF4 | ADP-ribosylation factor 4 | -0.0125113 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0124616 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0124194 |
| AGRN | agrin | -0.0124 |
| COLGALT1 | collagen beta(1-O)galactosyltransferase 1 | -0.0122974 |
| CSPP1 | centrosome and spindle pole associated protein 1 | -0.0120392 |
| NREP | neuronal regeneration related protein | -0.0120275 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0119771 |
| PXDN | peroxidasin | -0.0119525 |
| VCAN | versican | -0.0119495 |
| CST3 | cystatin C | -0.0118291 |
| EHD2 | EH-domain containing 2 | -0.0117748 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0116974 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0116515 |
| TPM1 | tropomyosin 1 (alpha) | -0.0115628 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | -0.0114311 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | -0.0113771 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.0113309 |
| ITGAV | integrin, alpha V | -0.0112028 |
| ECE1 | endothelin converting enzyme 1 | -0.011107 |
| TPM2 | tropomyosin 2 (beta) | -0.0109276 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.010886 |
| RPS14 | ribosomal protein S14 | -0.0108062 |
| PIGT | phosphatidylinositol glycan anchor biosynthesis, class T | -0.0107885 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0107359 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0106703 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0106213 |
| CD44 | CD44 molecule (Indian blood group) | -0.0105752 |
