| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.12532 |
| DSCAM | Down syndrome cell adhesion molecule | 0.125272 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.103651 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0934878 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0842985 |
| OGA | O-GlcNAcase | 0.0781025 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0777353 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0736889 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0711547 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0680807 |
| CALR | calreticulin | 0.0654421 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0651665 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0645456 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0622373 |
| HYOU1 | hypoxia up-regulated 1 | 0.0600346 |
| PTK2 | protein tyrosine kinase 2 | 0.0581434 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0576716 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0553403 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0545568 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0539736 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0537115 |
| KRT8 | keratin 8, type II | 0.0527786 |
| ANKRD11 | ankyrin repeat domain 11 | 0.05154 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0509327 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0502969 |
| GOLGA4 | golgin A4 | 0.0500568 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0496277 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.049385 |
| PTMA | prothymosin, alpha | 0.0484324 |
| CLTC | clathrin, heavy chain (Hc) | 0.0479148 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0469462 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0461946 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0461699 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0460847 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0457101 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0450821 |
| PDZD8 | PDZ domain containing 8 | 0.0450752 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0450722 |
| COG5 | component of oligomeric golgi complex 5 | 0.0450325 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0446829 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0445297 |
| HELZ | helicase with zinc finger | 0.044069 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0430034 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.042979 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0426043 |
| ATXN1 | ataxin 1 | 0.0416865 |
| VEGFA | vascular endothelial growth factor A | 0.0414714 |
| PLEC | plectin | 0.0413401 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0409075 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0405401 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0397781 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0393851 |
| KRT18 | keratin 18, type I | 0.0392381 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0391074 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0390371 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0390153 |
| MKI67 | marker of proliferation Ki-67 | 0.0389579 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0388719 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0384172 |
| SUCO | SUN domain containing ossification factor | 0.0383613 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0383258 |
| TPR | translocated promoter region, nuclear basket protein | 0.0381263 |
| FAM135A | family with sequence similarity 135, member A | 0.0379094 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0378785 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0377196 |
| FNIP1 | folliculin interacting protein 1 | 0.0372624 |
| USP3 | ubiquitin specific peptidase 3 | 0.0371665 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0371451 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0369324 |
| EFR3A | EFR3 homolog A (S. cerevisiae) | 0.0366095 |
| ACTN4 | actinin, alpha 4 | 0.0364431 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0361804 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0359194 |
| RBM33 | RNA binding motif protein 33 | 0.0358762 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.035807 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0357977 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.035618 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0354921 |
| CALU | calumenin | 0.0352049 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0351597 |
| RBM39 | RNA binding motif protein 39 | 0.0351374 |
| NCKAP1 | NCK-associated protein 1 | 0.035133 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0350313 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.034775 |
| PDS5B | PDS5 cohesin associated factor B | 0.0346764 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0344533 |
| ABHD2 | abhydrolase domain containing 2 | 0.0340377 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0336444 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0333142 |
| CCNL1 | cyclin L1 | 0.0331678 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0330285 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.0328169 |
| AFDN | afadin, adherens junction formation factor | 0.0327917 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0325796 |
| SBF2 | SET binding factor 2 | 0.0325551 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0323611 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0323028 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0322842 |
| CUL3 | cullin 3 | 0.0322272 |
| XPOT | exportin, tRNA | 0.0321375 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.129369 |
| KRT20 | keratin 20, type I | -0.113349 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0971535 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0969876 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0915693 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0912735 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0794673 |
| LAMA4 | laminin, alpha 4 | -0.0765743 |
| EGR1 | early growth response 1 | -0.0709357 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0709039 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0668421 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0662679 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0610042 |
| POF1B | premature ovarian failure, 1B | -0.0564696 |
| MYO1E | myosin IE | -0.0558792 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0531114 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.052708 |
| DIAPH2 | diaphanous-related formin 2 | -0.0521424 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0510923 |
| RPLP1 | ribosomal protein, large, P1 | -0.0503295 |
| FRY | furry homolog (Drosophila) | -0.0493155 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.048919 |
| TRIB1 | tribbles pseudokinase 1 | -0.0488708 |
| SLC45A4 | solute carrier family 45, member 4 | -0.04669 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0457893 |
| INTS6 | integrator complex subunit 6 | -0.0457808 |
| TJP1 | tight junction protein 1 | -0.044069 |
| TMSB10 | thymosin beta 10 | -0.0439564 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0437703 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0432112 |
| RPL35A | ribosomal protein L35a | -0.0430263 |
| KRT19 | keratin 19, type I | -0.0422587 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0416653 |
| JUN | jun proto-oncogene | -0.0407726 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0402199 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0398581 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0392501 |
| RPLP0 | ribosomal protein, large, P0 | -0.037921 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0376531 |
| MMP7 | matrix metallopeptidase 7 | -0.0373364 |
| S100A10 | S100 calcium binding protein A10 | -0.0371306 |
| RPS6 | ribosomal protein S6 | -0.0367135 |
| NDRG1 | N-myc downstream regulated 1 | -0.0365398 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0361065 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0357807 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0356916 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0342208 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.0336411 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0327405 |
| S100A6 | S100 calcium binding protein A6 | -0.0322112 |
| NTN4 | netrin 4 | -0.0319547 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0315328 |
| KLK10 | kallikrein-related peptidase 10 | -0.0314731 |
| EXOC4 | exocyst complex component 4 | -0.0314569 |
| LMO7 | LIM domain 7 | -0.0310645 |
| LYZ | lysozyme | -0.0306776 |
| GSN | gelsolin | -0.0299319 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0299064 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0294784 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0288173 |
| DGKH | diacylglycerol kinase, eta | -0.0287701 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0284525 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0284271 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0274302 |
| TLE4 | transducin-like enhancer of split 4 | -0.0267382 |
| ETV6 | ets variant 6 | -0.0266422 |
| RPL34 | ribosomal protein L34 | -0.0265267 |
| PRR5L | proline rich 5 like | -0.0261474 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0260038 |
| RPL27A | ribosomal protein L27a | -0.0254759 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0251554 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0250541 |
| HMGB1 | high mobility group box 1 | -0.0243754 |
| HMGA2 | high mobility group AT-hook 2 | -0.0241753 |
| CAPN8 | calpain 8 | -0.0237038 |
| FBXO11 | F-box protein 11 | -0.0235853 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0227459 |
| SGMS2 | sphingomyelin synthase 2 | -0.0227384 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0226779 |
| NPC1 | Niemann-Pick disease, type C1 | -0.022474 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0224328 |
| PCED1B | PC-esterase domain containing 1B | -0.0223428 |
| CA12 | carbonic anhydrase XII | -0.022335 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0222594 |
| ITGA1 | integrin, alpha 1 | -0.022186 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | -0.0218909 |
| TMC5 | transmembrane channel-like 5 | -0.0216584 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0215292 |
| RPS24 | ribosomal protein S24 | -0.0215102 |
| RPS8 | ribosomal protein S8 | -0.0213293 |
| CUX1 | cut-like homeobox 1 | -0.0208232 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0207238 |
| PAQR5 | progestin and adipoQ receptor family member V | -0.020469 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0203007 |
| RRBP1 | ribosome binding protein 1 | -0.0202962 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0202928 |
| ASPH | aspartate beta-hydroxylase | -0.0201753 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0197945 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0197664 |
| RAD51B | RAD51 paralog B | -0.0196698 |
