| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | 0.125017 |
| FNDC3B | fibronectin type III domain containing 3B | 0.124297 |
| FN1 | fibronectin 1 | 0.106574 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0943314 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0915194 |
| SDC4 | syndecan 4 | 0.0889523 |
| TF | transferrin | 0.0882899 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0860589 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0815375 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0777562 |
| AFDN | afadin, adherens junction formation factor | 0.075329 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0752939 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0687539 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0653192 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0613476 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0592417 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0579699 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0574916 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.057324 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0565031 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0543887 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0539289 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0524305 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0523312 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0511058 |
| RPL37A | ribosomal protein L37a | 0.050141 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0478368 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0450795 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0447172 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0446715 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.044263 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0437725 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0436999 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.043635 |
| CFB | complement factor B | 0.0434046 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0408802 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0402077 |
| GPC3 | glypican 3 | 0.039883 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0398443 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0393414 |
| CALR | calreticulin | 0.0385183 |
| TRIM26 | tripartite motif containing 26 | 0.0384875 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0373096 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0369291 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0366011 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0364306 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0360007 |
| C3 | complement component 3 | 0.0357521 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0351606 |
| RPL7A | ribosomal protein L7a | 0.0350874 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0350283 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0346787 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0345718 |
| RPS12 | ribosomal protein S12 | 0.0340964 |
| CCNL1 | cyclin L1 | 0.033865 |
| CRLS1 | cardiolipin synthase 1 | 0.033289 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0330906 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0329452 |
| RAB6A | RAB6A, member RAS oncogene family | 0.032716 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0327055 |
| MSI2 | musashi RNA-binding protein 2 | 0.0321139 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0316265 |
| VEGFA | vascular endothelial growth factor A | 0.0315237 |
| TNS1 | tensin 1 | 0.0314974 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0312763 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0311613 |
| NCKAP1 | NCK-associated protein 1 | 0.0308914 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0307215 |
| JAK1 | Janus kinase 1 | 0.0304869 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0302154 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0299356 |
| RPS17 | ribosomal protein S17 | 0.0297184 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0296063 |
| RBM25 | RNA binding motif protein 25 | 0.0294228 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0293323 |
| IL4R | interleukin 4 receptor | 0.0293237 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0292816 |
| CCNY | cyclin Y | 0.0290342 |
| MRTFA | myocardin related transcription factor A | 0.0289205 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0288408 |
| WDR43 | WD repeat domain 43 | 0.0288117 |
| WTAP | Wilms tumor 1 associated protein | 0.0286932 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0282931 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0282582 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0282111 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0281572 |
| LRRC1 | leucine rich repeat containing 1 | 0.0279047 |
| APOA1 | apolipoprotein A-I | 0.0278799 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.027876 |
| MALT1 | MALT1 paracaspase | 0.0277046 |
| RPS6 | ribosomal protein S6 | 0.0275375 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0274937 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0272906 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0272671 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0271852 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0264899 |
| SETD5 | SET domain containing 5 | 0.0264247 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.026372 |
| AHSG | alpha-2-HS-glycoprotein | 0.0260363 |
| TLK1 | tousled-like kinase 1 | 0.0254855 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.461382 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.136267 |
| IGF2 | insulin-like growth factor 2 | -0.0922135 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0869421 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0794021 |
| GPC6 | glypican 6 | -0.0769104 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0738684 |
| EHBP1 | EH domain binding protein 1 | -0.0705999 |
| INTS6 | integrator complex subunit 6 | -0.0705771 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0640676 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0635407 |
| H1-0 | H1.0 linker histone | -0.0583633 |
| DST | dystonin | -0.0527186 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0511793 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0496024 |
| FAM107B | family with sequence similarity 107, member B | -0.0474018 |
| ENO1 | enolase 1, (alpha) | -0.0470437 |
| NDRG1 | N-myc downstream regulated 1 | -0.0467501 |
| EPAS1 | endothelial PAS domain protein 1 | -0.045104 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0448691 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.044636 |
| PTCHD4 | patched domain containing 4 | -0.0446297 |
| VCL | vinculin | -0.0442893 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0439029 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0438197 |
| ASPH | aspartate beta-hydroxylase | -0.0437127 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0435097 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0408237 |
| NABP1 | nucleic acid binding protein 1 | -0.0405833 |
| FTL | ferritin, light polypeptide | -0.0396929 |
| FRMD5 | FERM domain containing 5 | -0.0396566 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0385476 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.0379265 |
| HMGA1 | high mobility group AT-hook 1 | -0.0374629 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0370129 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0350049 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0335477 |
| CLIC4 | chloride intracellular channel 4 | -0.0332876 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0331245 |
| SEPTIN9 | septin 9 | -0.0329817 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0324224 |
| PALLD | palladin, cytoskeletal associated protein | -0.0322191 |
| LDHA | lactate dehydrogenase A | -0.0301558 |
| MYO1E | myosin IE | -0.0298897 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0291918 |
| STK17A | serine/threonine kinase 17a | -0.028461 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0279563 |
| MT2A | metallothionein 2A | -0.0275342 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0267414 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0267354 |
| HDAC4 | histone deacetylase 4 | -0.0266917 |
| DSPP | dentin sialophosphoprotein | -0.0266445 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0264765 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0262712 |
| PKM | pyruvate kinase, muscle | -0.0262538 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | -0.0256213 |
| PLIN2 | perilipin 2 | -0.0254477 |
| CMIP | c-Maf inducing protein | -0.025313 |
| PRDM2 | PR domain containing 2, with ZNF domain | -0.0251302 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0249007 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0246392 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0246324 |
| C6ORF62 | chromosome 6 open reading frame 62 | -0.0235336 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -0.0234032 |
| EGR1 | early growth response 1 | -0.0232317 |
| RPS5 | ribosomal protein S5 | -0.0230498 |
| KIF21A | kinesin family member 21A | -0.0230426 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0226559 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0224509 |
| ZNF644 | zinc finger protein 644 | -0.022185 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0221053 |
| RUNX1 | runt-related transcription factor 1 | -0.0218584 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.0216273 |
| PRKCA | protein kinase C, alpha | -0.0215425 |
| RPLP0 | ribosomal protein, large, P0 | -0.0215343 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0213999 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0213255 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0209214 |
| ZNF609 | zinc finger protein 609 | -0.0208359 |
| RPLP1 | ribosomal protein, large, P1 | -0.0206627 |
| ATXN1 | ataxin 1 | -0.0206525 |
| CCDC138 | coiled-coil domain containing 138 | -0.0205724 |
| TLE4 | transducin-like enhancer of split 4 | -0.0205433 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0204808 |
| TMSB10 | thymosin beta 10 | -0.0204593 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.020433 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0204316 |
| RYBP | RING1 and YY1 binding protein | -0.0203386 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0202839 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.02021 |
| SP100 | SP100 nuclear antigen | -0.0201835 |
| VMP1 | vacuole membrane protein 1 | -0.0200899 |
| POTEF | POTE ankyrin domain family, member F | -0.0198222 |
| GOLGB1 | golgin B1 | -0.0198043 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0197309 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0195252 |
| PEG10 | paternally expressed 10 | -0.0190551 |
| ATF6 | activating transcription factor 6 | -0.0189382 |
| HPCAL1 | hippocalcin-like 1 | -0.018803 |
| KIZ | kizuna centrosomal protein | -0.0187457 |
