| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FLNB | filamin B, beta | 0.154291 |
| PLEC | plectin | 0.0959455 |
| PODXL | podocalyxin-like | 0.0818618 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0786675 |
| RBM39 | RNA binding motif protein 39 | 0.0781407 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0762496 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0737344 |
| TMSB4X | thymosin beta 4, X-linked | 0.0690769 |
| PTMA | prothymosin, alpha | 0.0665725 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0619454 |
| OGA | O-GlcNAcase | 0.0592378 |
| COL17A1 | collagen, type XVII, alpha 1 | 0.0590541 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0572564 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0568001 |
| BLCAP | bladder cancer associated protein | 0.0548888 |
| MEF2A | myocyte enhancer factor 2A | 0.0542374 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0540993 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0499686 |
| EFHD2 | EF-hand domain family, member D2 | 0.049814 |
| SQLE | squalene epoxidase | 0.0492592 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.0492585 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0490516 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0460616 |
| MSN | moesin | 0.046045 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0438237 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.0431261 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0420122 |
| KIAA1217 | KIAA1217 | 0.041503 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0406494 |
| TPM3 | tropomyosin 3 | 0.0404132 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0397401 |
| BCL2L1 | BCL2-like 1 | 0.0394136 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | 0.0393814 |
| LAMA5 | laminin, alpha 5 | 0.0390132 |
| SMAD3 | SMAD family member 3 | 0.03891 |
| FLNA | filamin A, alpha | 0.037991 |
| LMNA | lamin A/C | 0.037961 |
| MCL1 | myeloid cell leukemia 1 | 0.0376483 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0368583 |
| APP | amyloid beta (A4) precursor protein | 0.0358522 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0358445 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0357389 |
| NAV2 | neuron navigator 2 | 0.0347586 |
| FOSL1 | FOS-like antigen 1 | 0.0343827 |
| KRT6A | keratin 6A, type II | 0.0340234 |
| SDC4 | syndecan 4 | 0.0337201 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0332142 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0328917 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0326163 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0324671 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0324303 |
| FNIP1 | folliculin interacting protein 1 | 0.0323989 |
| EMP1 | epithelial membrane protein 1 | 0.0323505 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0320572 |
| NECTIN4 | nectin cell adhesion molecule 4 | 0.0319664 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0315194 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0309687 |
| KRT17 | keratin 17, type I | 0.030631 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0304249 |
| MEGF6 | multiple EGF-like-domains 6 | 0.0303754 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0302984 |
| SLK | STE20-like kinase | 0.0302116 |
| AMOTL1 | angiomotin like 1 | 0.030072 |
| SERINC3 | serine incorporator 3 | 0.0299371 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.0298375 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0295387 |
| SLMAP | sarcolemma associated protein | 0.0294806 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.0294589 |
| PCDH1 | protocadherin 1 | 0.0291923 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.029155 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0291207 |
| DIDO1 | death inducer-obliterator 1 | 0.0290215 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.0288678 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0286867 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0282588 |
| LAMC2 | laminin, gamma 2 | 0.0282555 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0280055 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0269489 |
| CEP250 | centrosomal protein 250kDa | 0.0268962 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0268277 |
| B2M | beta-2-microglobulin | 0.0267826 |
| PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | 0.0267115 |
| SPAG9 | sperm associated antigen 9 | 0.026691 |
| ADM | adrenomedullin | 0.0261371 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0260751 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0259842 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0259502 |
| MYO10 | myosin X | 0.0259381 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0257473 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.025629 |
| CAPRIN2 | caprin family member 2 | 0.0255825 |
| CD47 | CD47 molecule | 0.0254758 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0254287 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0253722 |
| ANXA11 | annexin A11 | 0.0253161 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0252065 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.024941 |
| PTK2 | protein tyrosine kinase 2 | 0.0247608 |
| OPTN | optineurin | 0.0247465 |
| CTTN | cortactin | 0.0246044 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.225239 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.160236 |
| MT2A | metallothionein 2A | -0.0961003 |
| NDRG1 | N-myc downstream regulated 1 | -0.0947996 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0900321 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0776598 |
| TMSB10 | thymosin beta 10 | -0.0763923 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0747951 |
| RPLP1 | ribosomal protein, large, P1 | -0.0668529 |
| ENO1 | enolase 1, (alpha) | -0.0600367 |
| ASPH | aspartate beta-hydroxylase | -0.0588762 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0553487 |
| INTS6 | integrator complex subunit 6 | -0.0538012 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0525415 |
| HMGA2 | high mobility group AT-hook 2 | -0.0501469 |
| CD44 | CD44 molecule (Indian blood group) | -0.0485839 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0455965 |
| RPS6 | ribosomal protein S6 | -0.0440303 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0439823 |
| RPS19 | ribosomal protein S19 | -0.0432093 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0419907 |
| STC1 | stanniocalcin 1 | -0.0419593 |
| S100A10 | S100 calcium binding protein A10 | -0.0412505 |
| RPLP2 | ribosomal protein, large, P2 | -0.0406605 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0378469 |
| CDK6 | cyclin-dependent kinase 6 | -0.036724 |
| RPS8 | ribosomal protein S8 | -0.0359787 |
| S100A6 | S100 calcium binding protein A6 | -0.0354408 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0354219 |
| FTL | ferritin, light polypeptide | -0.0348061 |
| RPL30 | ribosomal protein L30 | -0.0337084 |
| DST | dystonin | -0.0333418 |
| RPL35A | ribosomal protein L35a | -0.033283 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0331581 |
| RPL34 | ribosomal protein L34 | -0.0326331 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0317863 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0316431 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0309448 |
| RPL27A | ribosomal protein L27a | -0.0303142 |
| PRSS23 | protease, serine, 23 | -0.030126 |
| RPL23 | ribosomal protein L23 | -0.0298455 |
| RAD51B | RAD51 paralog B | -0.0298174 |
| RPL12 | ribosomal protein L12 | -0.0297907 |
| UBC | ubiquitin C | -0.029183 |
| RPL32 | ribosomal protein L32 | -0.0287659 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0287411 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0281393 |
| FOXP1 | forkhead box P1 | -0.0281231 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0279986 |
| SMYD3 | SET and MYND domain containing 3 | -0.0279135 |
| RPLP0 | ribosomal protein, large, P0 | -0.0278841 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0276534 |
| RPL8 | ribosomal protein L8 | -0.0271143 |
| RPL11 | ribosomal protein L11 | -0.0270128 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0267691 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0264177 |
| RPS23 | ribosomal protein S23 | -0.0261356 |
| TXNRD1 | thioredoxin reductase 1 | -0.0257169 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.025582 |
| FN1 | fibronectin 1 | -0.0254618 |
| LDHA | lactate dehydrogenase A | -0.0250157 |
| RPS27A | ribosomal protein S27a | -0.024475 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0244506 |
| DOK5 | docking protein 5 | -0.0242876 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0242526 |
| MYOF | myoferlin | -0.0237916 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.023725 |
| HMGB1 | high mobility group box 1 | -0.0236428 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0234726 |
| MYO9A | myosin IXA | -0.0234657 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0226642 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0224321 |
| CSMD2 | CUB and Sushi multiple domains 2 | -0.0221816 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0218678 |
| GNAS | GNAS complex locus | -0.0218667 |
| RPS27 | ribosomal protein S27 | -0.0218093 |
| H1-0 | H1.0 linker histone | -0.0216943 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | -0.0213402 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0213324 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0212436 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0212082 |
| RPL35 | ribosomal protein L35 | -0.0208108 |
| AHNAK | AHNAK nucleoprotein | -0.0207165 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0206391 |
| POTEF | POTE ankyrin domain family, member F | -0.0206071 |
| RPS20 | ribosomal protein S20 | -0.0204062 |
| RACK1 | receptor for activated C kinase 1 | -0.0203287 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0201877 |
| EXOC4 | exocyst complex component 4 | -0.0201626 |
| CNTNAP3 | contactin associated protein-like 3 | -0.0201297 |
| RPL28 | ribosomal protein L28 | -0.0201013 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0199768 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.019851 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0197488 |
| RTN3 | reticulon 3 | -0.0195865 |
| IER3 | immediate early response 3 | -0.0191983 |
| ARF1 | ADP-ribosylation factor 1 | -0.0191279 |
| RPS13 | ribosomal protein S13 | -0.0190814 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0190077 |
| RPL36 | ribosomal protein L36 | -0.0189112 |
