Topotecan (hydrochloride)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Topotecan (hydrochloride) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Topotecan (hydrochloride)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.272927
ADM adrenomedullin 0.143749
MT2A metallothionein 2A 0.101624
ZNF841 zinc finger protein 841 0.0998933
HLA-B major histocompatibility complex, class I, B 0.0807976
CALR calreticulin 0.0703665
CCNL1 cyclin L1 0.0627066
AKAP12 A kinase (PRKA) anchor protein 12 0.062102
TMSB4X thymosin beta 4, X-linked 0.0605325
NDRG1 N-myc downstream regulated 1 0.0589883
VEGFA vascular endothelial growth factor A 0.0568696
UGCG UDP-glucose ceramide glucosyltransferase 0.055127
HLA-C major histocompatibility complex, class I, C 0.0547309
BHLHE40 basic helix-loop-helix family, member e40 0.053075
SDC4 syndecan 4 0.0477856
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0467048
MYH9 myosin, heavy chain 9, non-muscle 0.0443983
SMAD3 SMAD family member 3 0.0441249
FOSL1 FOS-like antigen 1 0.0437351
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0423639
ATP13A3 ATPase type 13A3 0.0419989
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0416749
PODXL podocalyxin-like 0.0398871
FLNB filamin B, beta 0.0389187
RND3 Rho family GTPase 3 0.0380795
DTNA dystrobrevin, alpha 0.0375988
B2M beta-2-microglobulin 0.037011
SRRM2 serine/arginine repetitive matrix 2 0.0358632
RPL7A ribosomal protein L7a 0.0355717
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.035564
NCOR2 nuclear receptor corepressor 2 0.0349389
HLA-A major histocompatibility complex, class I, A 0.0349294
NAV2 neuron navigator 2 0.0343514
PLEC plectin 0.0342842
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0339594
NAMPT nicotinamide phosphoribosyltransferase 0.032612
EEF2 eukaryotic translation elongation factor 2 0.0314837
FLNA filamin A, alpha 0.0313319
WSB1 WD repeat and SOCS box containing 1 0.0308151
RPL35A ribosomal protein L35a 0.030774
P4HB prolyl 4-hydroxylase, beta polypeptide 0.029968
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0299629
RPN1 ribophorin I 0.0293641
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0288635
TNIP1 TNFAIP3 interacting protein 1 0.0288227
CEP250 centrosomal protein 250kDa 0.0284551
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.028043
COL7A1 collagen, type VII, alpha 1 0.0279786
NUP58 nucleoporin 58 0.0274115
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0270491
RPS6 ribosomal protein S6 0.0267981
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0267402
IRS2 insulin receptor substrate 2 0.0266275
PRRC2A proline-rich coiled-coil 2A 0.0266219
ZNF160 zinc finger protein 160 0.0262378
TPR translocated promoter region, nuclear basket protein 0.0261941
ARGLU1 arginine and glutamate rich 1 0.0259621
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.025464
ZFP36L1 ZFP36 ring finger protein-like 1 0.0249596
RSRC2 arginine/serine-rich coiled-coil 2 0.0249584
YBX1 Y box binding protein 1 0.0246579
SHB Src homology 2 domain containing adaptor protein B 0.0243343
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.0242724
ANKRD33B ankyrin repeat domain 33B 0.024179
CXCL8 chemokine (C-X-C motif) ligand 8 0.0239579
PIAS2 protein inhibitor of activated STAT, 2 0.0238586
ZNF432 zinc finger protein 432 0.0237827
KMT2E lysine (K)-specific methyltransferase 2E 0.0236884
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0236779
L1CAM L1 cell adhesion molecule 0.0235022
AFF1 AF4/FMR2 family, member 1 0.0233024
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0232405
SPACA6 sperm acrosome associated 6 0.0230929
MAP2K1 mitogen-activated protein kinase kinase 1 0.0230772
UBA6 ubiquitin-like modifier activating enzyme 6 0.0229158
BRD2 bromodomain containing 2 0.0224822
SPAG9 sperm associated antigen 9 0.0223193
RPS17 ribosomal protein S17 0.0223099
ACTG1 actin gamma 1 0.0222246
EHBP1L1 EH domain binding protein 1-like 1 0.0221332
RPS3 ribosomal protein S3 0.021978
RPS19 ribosomal protein S19 0.0219264
USP36 ubiquitin specific peptidase 36 0.0214037
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0214021
MCL1 myeloid cell leukemia 1 0.0213882
PTMA prothymosin, alpha 0.0213204
FGFR1 fibroblast growth factor receptor 1 0.0208394
COL5A1 collagen, type V, alpha 1 0.0206364
SRRM1 serine/arginine repetitive matrix 1 0.0206208
FOXO3 forkhead box O3 0.0203258
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0200416
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0200011
EEF1G eukaryotic translation elongation factor 1 gamma 0.0199867
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0199241
STC2 stanniocalcin 2 0.0198157
ENO2 enolase 2 (gamma, neuronal) 0.0193677
CNOT12 CCR4-NOT transcription complex subunit 12 0.0192637
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0191654
FAM219A family with sequence similarity 219, member A 0.0190778
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0190374

decreased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 -0.19773
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.157965
ENO1 enolase 1, (alpha) -0.116252
TXNRD1 thioredoxin reductase 1 -0.113728
GLIS3 GLIS family zinc finger 3 -0.091231
EXT1 exostosin glycosyltransferase 1 -0.0887985
ABI3BP ABI family, member 3 (NESH) binding protein -0.0848525
DLG1 discs, large homolog 1 (Drosophila) -0.075977
PLCB4 phospholipase C, beta 4 -0.0711812
ZBTB20 zinc finger and BTB domain containing 20 -0.0701229
RAI14 retinoic acid induced 14 -0.0689618
DST dystonin -0.068298
CANX calnexin -0.0645477
FNDC3B fibronectin type III domain containing 3B -0.060961
ASPH aspartate beta-hydroxylase -0.0576307
SAMD12 sterile alpha motif domain containing 12 -0.056856
PDIA3 protein disulfide isomerase family A, member 3 -0.0555013
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0542114
DIAPH3 diaphanous-related formin 3 -0.0529746
UBC ubiquitin C -0.0527301
POSTN periostin, osteoblast specific factor -0.0522104
ERBIN erbb2 interacting protein -0.051893
AHNAK AHNAK nucleoprotein -0.0504468
MAP1B microtubule-associated protein 1B -0.0479678
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0479671
MAP4 microtubule-associated protein 4 -0.0470745
DEK DEK proto-oncogene -0.0468802
NF1 neurofibromin 1 -0.0454907
SBF2 SET binding factor 2 -0.0425888
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0423444
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.042251
RHOBTB3 Rho-related BTB domain containing 3 -0.0421932
PARD3B par-3 family cell polarity regulator beta -0.0417885
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0401495
MT1X metallothionein 1X -0.0393488
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0390815
PPME1 protein phosphatase methylesterase 1 -0.0389064
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0385708
TENM3 teneurin transmembrane protein 3 -0.0381688
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0379835
CENPF centromere protein F, 350/400kDa -0.0376872
ZNF804A zinc finger protein 804A -0.0376286
PTPRG protein tyrosine phosphatase, receptor type, G -0.0376159
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.03754
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0375162
SLIT2 slit homolog 2 (Drosophila) -0.0372645
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0370778
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0363541
HMGB2 high mobility group box 2 -0.0363513
DPYD dihydropyrimidine dehydrogenase -0.0363223
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.036126
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0361115
CUL4B cullin 4B -0.0359292
LDHA lactate dehydrogenase A -0.0357138
IL6ST interleukin 6 signal transducer -0.0356937
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0355714
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0355208
FOXP1 forkhead box P1 -0.0350422
HEG1 heart development protein with EGF-like domains 1 -0.0343439
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0341021
CCBE1 collagen and calcium binding EGF domains 1 -0.0340494
SMYD3 SET and MYND domain containing 3 -0.0338726
FSTL1 follistatin-like 1 -0.0338249
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0336702
CTSD cathepsin D -0.032959
SLC12A8 solute carrier family 12, member 8 -0.0319982
RAD51B RAD51 paralog B -0.0319181
VEGFC vascular endothelial growth factor C -0.0318572
HLA-E major histocompatibility complex, class I, E -0.0313903
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0313682
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0311126
CCND1 cyclin D1 -0.0309388
C6ORF62 chromosome 6 open reading frame 62 -0.0307062
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0301861
CDK6 cyclin-dependent kinase 6 -0.0298518
PBX3 pre-B-cell leukemia homeobox 3 -0.0296701
LPP LIM domain containing preferred translocation partner in lipoma -0.0293677
TMEM178B transmembrane protein 178B -0.0288959
SULF1 sulfatase 1 -0.0286823
RTN3 reticulon 3 -0.0285728
COL3A1 collagen, type III, alpha 1 -0.0285452
VMP1 vacuole membrane protein 1 -0.0284474
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0283857
STAU1 staufen double-stranded RNA binding protein 1 -0.0282792
PTPRK protein tyrosine phosphatase, receptor type, K -0.0277406
NEK7 NIMA-related kinase 7 -0.0277101
STAU2 staufen double-stranded RNA binding protein 2 -0.0272641
TPM1 tropomyosin 1 (alpha) -0.0270565
FTL ferritin, light polypeptide -0.0270483
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0267761
BBX bobby sox homolog (Drosophila) -0.0267706
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0266409
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0265627
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -0.0264804
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0259532
CD44 CD44 molecule (Indian blood group) -0.0259302
FAF1 Fas (TNFRSF6) associated factor 1 -0.0258555
PKP4 plakophilin 4 -0.0258428
TPX2 TPX2, microtubule-associated -0.0257529
RSRC1 arginine/serine-rich coiled-coil 1 -0.0254635