| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in LOX-IMVI cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Topotecan (hydrochloride)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MMP12 | matrix metallopeptidase 12 | 0.170873 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.135238 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.131831 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.123125 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.113348 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.110609 |
| ZNF292 | zinc finger protein 292 | 0.109803 |
| NUP58 | nucleoporin 58 | 0.105803 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.102893 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0949809 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0934361 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0890134 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0819784 |
| CD109 | CD109 molecule | 0.0766558 |
| VIM | vimentin | 0.0755099 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0736221 |
| RNF145 | ring finger protein 145 | 0.0706324 |
| YBX3 | Y box binding protein 3 | 0.0678671 |
| HELZ | helicase with zinc finger | 0.0655277 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0653123 |
| SPAG9 | sperm associated antigen 9 | 0.0642253 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0632898 |
| TXNIP | thioredoxin interacting protein | 0.0630906 |
| RPS6 | ribosomal protein S6 | 0.062814 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0621897 |
| MSN | moesin | 0.0620989 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.061618 |
| ATP13A3 | ATPase type 13A3 | 0.0609216 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.060709 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0588272 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0571855 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0571173 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0557627 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0542159 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0541104 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0540462 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0532696 |
| SETD5 | SET domain containing 5 | 0.0515757 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0509999 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0497974 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0494316 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0493025 |
| RLF | rearranged L-myc fusion | 0.0485431 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0474772 |
| RBM39 | RNA binding motif protein 39 | 0.0469759 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.046779 |
| PGK1 | phosphoglycerate kinase 1 | 0.0466505 |
| NCKAP1 | NCK-associated protein 1 | 0.0464226 |
| RTN4 | reticulon 4 | 0.0464079 |
| MED13L | mediator complex subunit 13-like | 0.0460424 |
| WDR43 | WD repeat domain 43 | 0.0457024 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0450813 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0450502 |
| USP3 | ubiquitin specific peptidase 3 | 0.0449956 |
| SEPTIN7 | septin 7 | 0.0445896 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0440051 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0439596 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0429889 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0429669 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0422539 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0412088 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0411113 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0410921 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0408816 |
| PCBP2 | poly(rC) binding protein 2 | 0.0407887 |
| QKI | QKI, KH domain containing, RNA binding | 0.0404881 |
| GOLGA4 | golgin A4 | 0.0404289 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0401706 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0401118 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0396665 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0396189 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0395774 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0395468 |
| TFG | TRK-fused gene | 0.039378 |
| DST | dystonin | 0.0389128 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0388425 |
| CCNL1 | cyclin L1 | 0.0386471 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0383729 |
| RPL21 | ribosomal protein L21 | 0.0382632 |
| OGA | O-GlcNAcase | 0.0380948 |
| KIF5B | kinesin family member 5B | 0.038049 |
| PHIP | pleckstrin homology domain interacting protein | 0.0377979 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0370927 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0370875 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0370715 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0370168 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0362167 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0360793 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0358216 |
| WDR45B | WD repeat domain 45B | 0.0354319 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.035317 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0350669 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0348061 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0347784 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0346219 |
| NGLY1 | N-glycanase 1 | 0.0344514 |
| NDRG1 | N-myc downstream regulated 1 | 0.0344317 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0342648 |
| SMAP1 | small ArfGAP 1 | 0.0341804 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0337494 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EXT1 | exostosin glycosyltransferase 1 | -0.140348 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0808352 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0783913 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.075457 |
| INTS6 | integrator complex subunit 6 | -0.0719309 |
| HMGA2 | high mobility group AT-hook 2 | -0.0654747 |
| KIAA1217 | KIAA1217 | -0.0635488 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0616039 |
| NTM | neurotrimin | -0.0577237 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0563051 |
| HDAC9 | histone deacetylase 9 | -0.050186 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.0499646 |
| CDH13 | cadherin 13 | -0.0497848 |
| NABP1 | nucleic acid binding protein 1 | -0.0479865 |
| NAV1 | neuron navigator 1 | -0.0472109 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0455768 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0452687 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0445362 |
| EGR1 | early growth response 1 | -0.0443111 |
| ADAM32 | ADAM metallopeptidase domain 32 | -0.0440529 |
| PTCHD4 | patched domain containing 4 | -0.0431325 |
| AEBP2 | AE binding protein 2 | -0.0430619 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.041199 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0410145 |
| ZNF804A | zinc finger protein 804A | -0.0410008 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0405066 |
| RPL35A | ribosomal protein L35a | -0.0387096 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0379953 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0369362 |
| ADAM19 | ADAM metallopeptidase domain 19 | -0.0368195 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0336418 |
| KIAA1549L | KIAA1549-like | -0.0326355 |
| KYNU | kynureninase | -0.0321923 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0318565 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0317601 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0306088 |
| SP100 | SP100 nuclear antigen | -0.030387 |
| VCL | vinculin | -0.0302693 |
| FMN1 | formin 1 | -0.0301977 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0300034 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0291153 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0289641 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0285317 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0283496 |
| CDK14 | cyclin-dependent kinase 14 | -0.0283367 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0279162 |
| NAV3 | neuron navigator 3 | -0.0275427 |
| RNF213 | ring finger protein 213 | -0.0274973 |
| RPS24 | ribosomal protein S24 | -0.0271161 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.027094 |
| CALD1 | caldesmon 1 | -0.0270642 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0270176 |
| ASPH | aspartate beta-hydroxylase | -0.0262426 |
| CAVIN1 | caveolae associated protein 1 | -0.0262351 |
| FLNA | filamin A, alpha | -0.0259396 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0258069 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0250896 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0246328 |
| CFAP251 | cilia and flagella associated protein 251 | -0.0246181 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0244686 |
| PCDH11X | protocadherin 11 X-linked | -0.0243236 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.0238796 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0236938 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0236308 |
| PRKCE | protein kinase C, epsilon | -0.0235956 |
| CDK6 | cyclin-dependent kinase 6 | -0.0232788 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0230422 |
| MSR1 | macrophage scavenger receptor 1 | -0.0229449 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0227447 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0225755 |
| CDK12 | cyclin-dependent kinase 12 | -0.0224264 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0218431 |
| MYO9A | myosin IXA | -0.0217833 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0217485 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0216429 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0216256 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0215023 |
| NETO1 | neuropilin (NRP) and tolloid (TLL)-like 1 | -0.0214796 |
| BPTF | bromodomain PHD finger transcription factor | -0.0214231 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0212128 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0210177 |
| CTIF | CBP80/20-dependent translation initiation factor | -0.0209074 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0209056 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0207162 |
| DGKI | diacylglycerol kinase, iota | -0.0204397 |
| COL27A1 | collagen, type XXVII, alpha 1 | -0.0203869 |
| NBEA | neurobeachin | -0.0203101 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0202241 |
| ATG7 | autophagy related 7 | -0.0200896 |
| RPL13A | ribosomal protein L13a | -0.0200108 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | -0.0196757 |
| IPO9 | importin 9 | -0.019506 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0194664 |
| EXOC4 | exocyst complex component 4 | -0.019166 |
| AHNAK | AHNAK nucleoprotein | -0.0191139 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0189635 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0188672 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0187634 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0186302 |
| SYT9 | synaptotagmin IX | -0.0185868 |
