Topotecan (hydrochloride)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Topotecan (hydrochloride) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Topotecan (hydrochloride)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.180535
TXNIP thioredoxin interacting protein 0.148128
FAM13A family with sequence similarity 13, member A 0.136511
DSPP dentin sialophosphoprotein 0.130844
KRT18 keratin 18, type I 0.12414
EREG epiregulin 0.112165
VEGFA vascular endothelial growth factor A 0.107575
RPS6 ribosomal protein S6 0.106466
NPSR1 neuropeptide S receptor 1 0.102873
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.100865
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0974756
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.095737
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.092679
NDRG1 N-myc downstream regulated 1 0.0916949
ANXA2 annexin A2 0.0771229
RPS2 ribosomal protein S2 0.0768854
PTPRR protein tyrosine phosphatase, receptor type, R 0.0733606
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0726773
SETD5 SET domain containing 5 0.0705897
CCNY cyclin Y 0.0670015
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0669967
UBA6 ubiquitin-like modifier activating enzyme 6 0.0666275
TNS4 tensin 4 0.0661537
FLNB filamin B, beta 0.0661202
ESYT2 extended synaptotagmin-like protein 2 0.0660122
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0653507
KMT2E lysine (K)-specific methyltransferase 2E 0.0643774
RNF145 ring finger protein 145 0.0634364
KRT19 keratin 19, type I 0.062214
RPL37A ribosomal protein L37a 0.0607434
SRRM2 serine/arginine repetitive matrix 2 0.0581234
DDIT4 DNA-damage-inducible transcript 4 0.0572296
ONECUT3 one cut homeobox 3 0.0561251
MED13L mediator complex subunit 13-like 0.0546261
PGK1 phosphoglycerate kinase 1 0.0536365
RPS12 ribosomal protein S12 0.0523413
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0516078
EHF ets homologous factor 0.0515577
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0494475
RPL11 ribosomal protein L11 0.0486945
ZNF292 zinc finger protein 292 0.0480681
TPM4 tropomyosin 4 0.0480109
WAC WW domain containing adaptor with coiled-coil 0.0479071
CALB1 calbindin 1, 28kDa 0.0475848
RPS19 ribosomal protein S19 0.0471829
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0465818
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0464903
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0458734
LRRC1 leucine rich repeat containing 1 0.0457111
ITGA6 integrin, alpha 6 0.045448
PTBP3 polypyrimidine tract binding protein 3 0.0453162
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0451894
PRRC2C proline-rich coiled-coil 2C 0.0440936
RAB1A RAB1A, member RAS oncogene family 0.0440584
RPL7A ribosomal protein L7a 0.0434396
RBM39 RNA binding motif protein 39 0.0422937
FNBP1L formin binding protein 1-like 0.0422177
DSG2 desmoglein 2 0.0421791
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.041286
ADD3 adducin 3 (gamma) 0.0410579
CD46 CD46 molecule, complement regulatory protein 0.0407475
YBX3 Y box binding protein 3 0.0405696
KIF5B kinesin family member 5B 0.0405623
WSB1 WD repeat and SOCS box containing 1 0.0403009
TMEM45B transmembrane protein 45B 0.0399014
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0397753
S100A6 S100 calcium binding protein A6 0.0395626
MXI1 MAX interactor 1, dimerization protein 0.0391253
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0391155
FERMT1 fermitin family member 1 0.0388845
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.038573
KTN1 kinectin 1 (kinesin receptor) 0.0381083
SLK STE20-like kinase 0.0375362
RREB1 ras responsive element binding protein 1 0.0372311
EPS8 epidermal growth factor receptor pathway substrate 8 0.0371259
ANKRD11 ankyrin repeat domain 11 0.036777
HSPA8 heat shock 70kDa protein 8 0.0365169
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0364152
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0357492
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0353804
KRT8 keratin 8, type II 0.0349853
LMO7 LIM domain 7 0.0349773
THOC2 THO complex 2 0.0349602
ITPRID2 ITPR interacting domain containing 2 0.0349384
PRSS3 protease, serine, 3 0.0345436
ABHD17C abhydrolase domain containing 17C 0.0342931
RPL12 ribosomal protein L12 0.0342512
PNISR PNN-interacting serine/arginine-rich protein 0.0341881
S100P S100 calcium binding protein P 0.0340176
KLF5 Kruppel-like factor 5 (intestinal) 0.0332242
ERRFI1 ERBB receptor feedback inhibitor 1 0.0329739
HELZ helicase with zinc finger 0.0328696
DSCAM Down syndrome cell adhesion molecule 0.0328368
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0326872
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.03248
RBM47 RNA binding motif protein 47 0.0322997
NCKAP1 NCK-associated protein 1 0.0322656
B2M beta-2-microglobulin 0.0322169
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0322108
RAB6A RAB6A, member RAS oncogene family 0.0321269

decreased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.163225
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.109978
GMDS GDP-mannose 4,6-dehydratase -0.104583
UBC ubiquitin C -0.072905
RPS27A ribosomal protein S27a -0.0537786
LOC112694756 uncharaterized LOC112694756 -0.0512904
GPHN gephyrin -0.0508451
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0462821
NEBL nebulette -0.046128
PDIA4 protein disulfide isomerase family A, member 4 -0.0435
NALF1 NALCN channel auxiliary factor 1 -0.0425691
FAT1 FAT atypical cadherin 1 -0.0424455
MYO1E myosin IE -0.0389765
FHIT fragile histidine triad -0.0386424
BTBD9 BTB (POZ) domain containing 9 -0.0366352
PTPRK protein tyrosine phosphatase, receptor type, K -0.0362048
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0356163
PARD3B par-3 family cell polarity regulator beta -0.0352683
ASPH aspartate beta-hydroxylase -0.0348527
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0335242
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0326133
RPLP1 ribosomal protein, large, P1 -0.0323263
ATXN1 ataxin 1 -0.0316575
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0316281
CADPS Ca++-dependent secretion activator -0.0316163
CCSER1 coiled-coil serine-rich protein 1 -0.0314714
JUN jun proto-oncogene -0.0313784
SLC38A2 solute carrier family 38, member 2 -0.0312195
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0310846
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0294136
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0290991
VCL vinculin -0.028499
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0277715
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0277205
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0271442
FTL ferritin, light polypeptide -0.0267687
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.025092
GCLC glutamate-cysteine ligase, catalytic subunit -0.0245588
ATF6 activating transcription factor 6 -0.0245397
TXNRD1 thioredoxin reductase 1 -0.0240632
EXT1 exostosin glycosyltransferase 1 -0.0240304
PTPRG protein tyrosine phosphatase, receptor type, G -0.0238624
PDIA3 protein disulfide isomerase family A, member 3 -0.0234427
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0233163
EPHB2 EPH receptor B2 -0.023282
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0225022
AHNAK AHNAK nucleoprotein -0.0219361
KDM4C lysine (K)-specific demethylase 4C -0.0215759
TJP1 tight junction protein 1 -0.0212055
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0211697
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0208956
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0206325
TAS2R14 taste receptor, type 2, member 14 -0.0205885
CADPS2 Ca++-dependent secretion activator 2 -0.0201144
SFPQ splicing factor proline/glutamine-rich -0.0200351
FAF1 Fas (TNFRSF6) associated factor 1 -0.0198948
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0197553
TGFBR3 transforming growth factor, beta receptor III -0.0194095
IARS1 isoleucyl-tRNA synthetase 1 -0.0192513
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.019233
HDAC4 histone deacetylase 4 -0.0192219
EGR1 early growth response 1 -0.0189459
DIAPH2 diaphanous-related formin 2 -0.0187626
SELENOK selenoprotein K -0.0187223
ZBTB20 zinc finger and BTB domain containing 20 -0.0187222
CEMIP2 cell migration inducing hyaluronidase 2 -0.018721
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0186851
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0185747
ABR active BCR-related -0.0185599
TRAPPC9 trafficking protein particle complex 9 -0.0182034
FOXN3 forkhead box N3 -0.0178516
ARB2A ARB2 cotranscriptional regulator A -0.0178007
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0177293
ANKRD17 ankyrin repeat domain 17 -0.0176199
LOC102724023 ES1 protein homolog, mitochondrial -0.0176065
RPL23 ribosomal protein L23 -0.0174134
RPS20 ribosomal protein S20 -0.0173376
RCC1 regulator of chromosome condensation 1 -0.0172787
FUS FUS RNA binding protein -0.0172541
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0172276
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0171898
ARHGAP42 Rho GTPase activating protein 42 -0.0171834
TRIB1 tribbles pseudokinase 1 -0.0171815
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0170844
MT2A metallothionein 2A -0.0167906
NPR2 natriuretic peptide receptor 2 -0.0166834
HMGB2 high mobility group box 2 -0.0165979
FBXL17 F-box and leucine-rich repeat protein 17 -0.0164369
TTC3 tetratricopeptide repeat domain 3 -0.0164022
H1-0 H1.0 linker histone -0.0163382
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0163176
TSC22D1 TSC22 domain family, member 1 -0.0162643
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0162574
GADD45A growth arrest and DNA-damage-inducible, alpha -0.016112
TIGAR TP53 induced glycolysis regulatory phosphatase -0.016008
CHD9 chromodomain helicase DNA binding protein 9 -0.0157172
NKD1 naked cuticle homolog 1 (Drosophila) -0.0155413
SCFD2 sec1 family domain containing 2 -0.0154521
CDK12 cyclin-dependent kinase 12 -0.0154409
MBD5 methyl-CpG binding domain protein 5 -0.015424