| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.142083 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.133426 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.123055 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.112762 |
| RPS12 | ribosomal protein S12 | 0.111831 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0975489 |
| FLNB | filamin B, beta | 0.09472 |
| FOXO1 | forkhead box O1 | 0.0920622 |
| ABHD17C | abhydrolase domain containing 17C | 0.0795381 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0750882 |
| PKP2 | plakophilin 2 | 0.075 |
| PRSS3 | protease, serine, 3 | 0.0734287 |
| VCL | vinculin | 0.0718033 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0682171 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | 0.0652925 |
| RNF145 | ring finger protein 145 | 0.0633746 |
| ITGA6 | integrin, alpha 6 | 0.0632988 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0538481 |
| DSPP | dentin sialophosphoprotein | 0.0535179 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.053356 |
| GOLGA4 | golgin A4 | 0.0514665 |
| RPL21 | ribosomal protein L21 | 0.0500743 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0491096 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.046435 |
| TMEM165 | transmembrane protein 165 | 0.0454729 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0454716 |
| PRELID2 | PRELI domain containing 2 | 0.0453894 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0444687 |
| SETD5 | SET domain containing 5 | 0.042872 |
| MYO1E | myosin IE | 0.0425445 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0417737 |
| ZNF292 | zinc finger protein 292 | 0.0410952 |
| RPS17 | ribosomal protein S17 | 0.0406798 |
| TMEM45B | transmembrane protein 45B | 0.0403144 |
| PDE8A | phosphodiesterase 8A | 0.0401697 |
| ETNK1 | ethanolamine kinase 1 | 0.0399111 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0398777 |
| RPS2 | ribosomal protein S2 | 0.0398716 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0390818 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0390212 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0388479 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0385742 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.038057 |
| WWC1 | WW and C2 domain containing 1 | 0.0377811 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0373237 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.037242 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0368822 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0362204 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0361138 |
| SEPTIN10 | septin 10 | 0.0358439 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0356967 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0348682 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0342914 |
| CALB1 | calbindin 1, 28kDa | 0.0341237 |
| JMJD1C | jumonji domain containing 1C | 0.0332634 |
| PLAC8 | placenta-specific 8 | 0.0330732 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0326069 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0323453 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0322047 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.032184 |
| FAT1 | FAT atypical cadherin 1 | 0.0321705 |
| PTEN | phosphatase and tensin homolog | 0.032098 |
| CDK19 | cyclin-dependent kinase 19 | 0.0319589 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0314687 |
| MYO6 | myosin VI | 0.031437 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.0312096 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | 0.0309656 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0304491 |
| RAD51B | RAD51 paralog B | 0.0302128 |
| CDC42SE2 | CDC42 small effector 2 | 0.0298857 |
| FHL2 | four and a half LIM domains 2 | 0.0298298 |
| NKTR | natural killer cell triggering receptor | 0.0297547 |
| ANXA11 | annexin A11 | 0.0295494 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0295143 |
| ABHD2 | abhydrolase domain containing 2 | 0.0292008 |
| LMO7 | LIM domain 7 | 0.0290814 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0288759 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0286602 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0286285 |
| BCL2L1 | BCL2-like 1 | 0.0285058 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0283706 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0283477 |
| SNX9 | sorting nexin 9 | 0.0282734 |
| RPL37A | ribosomal protein L37a | 0.0282455 |
| DSG3 | desmoglein 3 | 0.0281597 |
| RPS7 | ribosomal protein S7 | 0.0281527 |
| EREG | epiregulin | 0.0280127 |
| TSPAN8 | tetraspanin 8 | 0.0279157 |
| MED13L | mediator complex subunit 13-like | 0.0278932 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0278743 |
| TMF1 | TATA element modulatory factor 1 | 0.0276938 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0275915 |
| UBE3A | ubiquitin protein ligase E3A | 0.0275134 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0274504 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0273608 |
| MYO1D | myosin ID | 0.0271385 |
| CAB39 | calcium binding protein 39 | 0.0266312 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0266031 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0264811 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.026314 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.17636 |
| RPLP1 | ribosomal protein, large, P1 | -0.129584 |
| TMSB10 | thymosin beta 10 | -0.126081 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0919084 |
| RPLP0 | ribosomal protein, large, P0 | -0.0906068 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0854279 |
| PKM | pyruvate kinase, muscle | -0.0778931 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0748919 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0712554 |
| ACTG1 | actin gamma 1 | -0.0704414 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0695881 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0672394 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0670683 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0639982 |
| MSI2 | musashi RNA-binding protein 2 | -0.0597349 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0593694 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.055963 |
| RPL4 | ribosomal protein L4 | -0.0547554 |
| INTS6 | integrator complex subunit 6 | -0.051971 |
| FUS | FUS RNA binding protein | -0.0508917 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0502328 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0500466 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0499193 |
| RPL13A | ribosomal protein L13a | -0.0496368 |
| RPL35A | ribosomal protein L35a | -0.0478191 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0477936 |
| RIMKLB | ribosomal modification protein rimK-like family member B | -0.0454204 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0431817 |
| HDLBP | high density lipoprotein binding protein | -0.0424827 |
| TC2N | tandem C2 domains, nuclear | -0.0424588 |
| RPL34 | ribosomal protein L34 | -0.0420134 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0400037 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.039011 |
| YBX1 | Y box binding protein 1 | -0.0389377 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0389081 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0380706 |
| CANX | calnexin | -0.0380611 |
| PTMA | prothymosin, alpha | -0.0378721 |
| HMGA1 | high mobility group AT-hook 1 | -0.0377471 |
| RPL27A | ribosomal protein L27a | -0.0374655 |
| S100A10 | S100 calcium binding protein A10 | -0.0372653 |
| ARF1 | ADP-ribosylation factor 1 | -0.0371356 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0371187 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0370867 |
| LDHA | lactate dehydrogenase A | -0.0369491 |
| IRF1 | interferon regulatory factor 1 | -0.0364666 |
| LRRC23 | leucine rich repeat containing 23 | -0.0364482 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0355346 |
| JUN | jun proto-oncogene | -0.0350666 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0336889 |
| EZR | ezrin | -0.0336096 |
| SQSTM1 | sequestosome 1 | -0.0335553 |
| SP100 | SP100 nuclear antigen | -0.0324559 |
| ANXA2 | annexin A2 | -0.0322329 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0320045 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0319878 |
| SPINK13 | serine peptidase inhibitor, Kazal type 13 (putative) | -0.0316061 |
| OXSR1 | oxidative stress responsive 1 | -0.0312098 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0310765 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0306268 |
| GDF15 | growth differentiation factor 15 | -0.0295446 |
| ATF4 | activating transcription factor 4 | -0.0293362 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0290944 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.029016 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0284141 |
| TBCA | tubulin folding cofactor A | -0.0283269 |
| NPR2 | natriuretic peptide receptor 2 | -0.028216 |
| ENO1 | enolase 1, (alpha) | -0.0279484 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.027665 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0276489 |
| RRBP1 | ribosome binding protein 1 | -0.0275866 |
| SKP1 | S-phase kinase-associated protein 1 | -0.0272475 |
| MT2A | metallothionein 2A | -0.0272447 |
| NDRG1 | N-myc downstream regulated 1 | -0.0271442 |
| MORF4L2 | mortality factor 4 like 2 | -0.026802 |
| RPL12 | ribosomal protein L12 | -0.0264899 |
| RPS16 | ribosomal protein S16 | -0.0264433 |
| POF1B | premature ovarian failure, 1B | -0.0261966 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0259701 |
| ATF3 | activating transcription factor 3 | -0.0259156 |
| UBAP2 | ubiquitin associated protein 2 | -0.0257865 |
| RPS24 | ribosomal protein S24 | -0.0257544 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.02552 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | -0.0254378 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0254167 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0251254 |
| RPS14 | ribosomal protein S14 | -0.0247771 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0242629 |
| RPL28 | ribosomal protein L28 | -0.0239281 |
| RPS5 | ribosomal protein S5 | -0.0239263 |
| PGK1 | phosphoglycerate kinase 1 | -0.023785 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0236674 |
| RPS20 | ribosomal protein S20 | -0.0234907 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.023455 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0234247 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0233252 |
| RNF213 | ring finger protein 213 | -0.0233077 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0232707 |
| TFRC | transferrin receptor | -0.0232641 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0232054 |
