| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.165714 |
| CAPRIN2 | caprin family member 2 | 0.102821 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.100775 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0971372 |
| PTMA | prothymosin, alpha | 0.095824 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0910487 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0825935 |
| DST | dystonin | 0.0703992 |
| RPS12 | ribosomal protein S12 | 0.0660654 |
| RPS2 | ribosomal protein S2 | 0.0659828 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0530837 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0522304 |
| MSN | moesin | 0.0518691 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0505067 |
| RPS6 | ribosomal protein S6 | 0.04907 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0481081 |
| GOLGA4 | golgin A4 | 0.0472681 |
| SETD5 | SET domain containing 5 | 0.0469917 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0462491 |
| TXNIP | thioredoxin interacting protein | 0.0460094 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0458627 |
| RPL37A | ribosomal protein L37a | 0.0455806 |
| SET | SET nuclear proto-oncogene | 0.0455335 |
| SLK | STE20-like kinase | 0.0449153 |
| CENPF | centromere protein F, 350/400kDa | 0.0444513 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.044268 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0431364 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0429936 |
| DOCK11 | dedicator of cytokinesis 11 | 0.0421786 |
| CDK19 | cyclin-dependent kinase 19 | 0.0412948 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0402118 |
| RBM25 | RNA binding motif protein 25 | 0.0401816 |
| TPM3 | tropomyosin 3 | 0.0399572 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.039832 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0394937 |
| YEATS2 | YEATS domain containing 2 | 0.0394322 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0384868 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0383857 |
| RAI1 | retinoic acid induced 1 | 0.0376587 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0373045 |
| RPS3 | ribosomal protein S3 | 0.0373025 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.036889 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0367837 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0366568 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0359692 |
| RPL7A | ribosomal protein L7a | 0.0358601 |
| PRELID2 | PRELI domain containing 2 | 0.0355871 |
| RPL21 | ribosomal protein L21 | 0.0351223 |
| XPO1 | exportin 1 | 0.0344732 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0341446 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0340879 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0338475 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0327057 |
| ZNF292 | zinc finger protein 292 | 0.0323763 |
| ANGPTL4 | angiopoietin-like 4 | 0.0310215 |
| NUP58 | nucleoporin 58 | 0.0306228 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0304028 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0302151 |
| EREG | epiregulin | 0.0300857 |
| RPS8 | ribosomal protein S8 | 0.0295244 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0292931 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0291081 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | 0.029092 |
| RPS29 | ribosomal protein S29 | 0.028878 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0287623 |
| PNN | pinin, desmosome associated protein | 0.0285336 |
| FNIP1 | folliculin interacting protein 1 | 0.028462 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0284055 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.028346 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0282553 |
| FOSL1 | FOS-like antigen 1 | 0.0280437 |
| RPS17 | ribosomal protein S17 | 0.0279886 |
| PCBP2 | poly(rC) binding protein 2 | 0.0279391 |
| RPL9 | ribosomal protein L9 | 0.0277312 |
| VEGFA | vascular endothelial growth factor A | 0.0276854 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0275443 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0275363 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0274421 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.027405 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0271182 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0269477 |
| RPL5 | ribosomal protein L5 | 0.0268727 |
| HDGF | hepatoma-derived growth factor | 0.0266813 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.026594 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0265331 |
| RNF145 | ring finger protein 145 | 0.0263252 |
| RPS23 | ribosomal protein S23 | 0.0260524 |
| MCL1 | myeloid cell leukemia 1 | 0.0260386 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0260089 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0259078 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0257777 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0255225 |
| TMEM41B | transmembrane protein 41B | 0.0252885 |
| SRGN | serglycin | 0.0252121 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0250666 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0248931 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0246369 |
| SNX14 | sorting nexin 14 | 0.0245582 |
| OPTN | optineurin | 0.0244085 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0234846 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.278159 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.275391 |
| VIM | vimentin | -0.147758 |
| TMSB10 | thymosin beta 10 | -0.139665 |
| LOC112694756 | uncharaterized LOC112694756 | -0.117781 |
| CD44 | CD44 molecule (Indian blood group) | -0.117348 |
| TP63 | tumor protein p63 | -0.116132 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.1069 |
| TXNRD1 | thioredoxin reductase 1 | -0.103905 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0834956 |
| TMSB4X | thymosin beta 4, X-linked | -0.0826867 |
| RPL35A | ribosomal protein L35a | -0.0740655 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0712425 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0685389 |
| RUNX1 | runt-related transcription factor 1 | -0.0644854 |
| FTL | ferritin, light polypeptide | -0.0626276 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.06133 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0588161 |
| RPLP1 | ribosomal protein, large, P1 | -0.0573673 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0568145 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.053561 |
| TFRC | transferrin receptor | -0.0508583 |
| NPR2 | natriuretic peptide receptor 2 | -0.0504253 |
| JUN | jun proto-oncogene | -0.0488809 |
| ARF1 | ADP-ribosylation factor 1 | -0.0473001 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0456284 |
| SP100 | SP100 nuclear antigen | -0.0445796 |
| FUS | FUS RNA binding protein | -0.0445582 |
| RPLP0 | ribosomal protein, large, P0 | -0.044472 |
| APP | amyloid beta (A4) precursor protein | -0.0441624 |
| GNAS | GNAS complex locus | -0.0432524 |
| HLA-B | major histocompatibility complex, class I, B | -0.042649 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.042601 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0412948 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.041176 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0409717 |
| ANXA2 | annexin A2 | -0.039957 |
| EHBP1 | EH domain binding protein 1 | -0.0395336 |
| EGR1 | early growth response 1 | -0.0388352 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0385003 |
| HDLBP | high density lipoprotein binding protein | -0.0366723 |
| LDHA | lactate dehydrogenase A | -0.0350286 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0348887 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0346217 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0345121 |
| AHNAK | AHNAK nucleoprotein | -0.0344614 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0343433 |
| RGS4 | regulator of G-protein signaling 4 | -0.0343058 |
| EPHA4 | EPH receptor A4 | -0.0342924 |
| TMEM123 | transmembrane protein 123 | -0.0339679 |
| CAVIN1 | caveolae associated protein 1 | -0.0337507 |
| FBXO11 | F-box protein 11 | -0.0332223 |
| CADM2 | cell adhesion molecule 2 | -0.0332192 |
| INTS6 | integrator complex subunit 6 | -0.0326995 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0326208 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0323865 |
| RPS24 | ribosomal protein S24 | -0.0323493 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0322903 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0313619 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0313512 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0312623 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0311416 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0309956 |
| KLF6 | Kruppel-like factor 6 | -0.0309845 |
| H1-0 | H1.0 linker histone | -0.0306388 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0303913 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0299434 |
| NF1 | neurofibromin 1 | -0.0294824 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0293832 |
| RPS28 | ribosomal protein S28 | -0.0290024 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0286113 |
| CANX | calnexin | -0.028229 |
| HMGA1 | high mobility group AT-hook 1 | -0.0281565 |
| HMGB1 | high mobility group box 1 | -0.0280072 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0276134 |
| MT1X | metallothionein 1X | -0.0272736 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -0.0271518 |
| LRRC23 | leucine rich repeat containing 23 | -0.0269477 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0267792 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0267524 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0262397 |
| ANXA1 | annexin A1 | -0.0260585 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0257652 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0257447 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0256886 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0252733 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0251233 |
| YBX1 | Y box binding protein 1 | -0.0249907 |
| RTN3 | reticulon 3 | -0.0248536 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0247944 |
| EMP1 | epithelial membrane protein 1 | -0.0246713 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0244361 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.024297 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0242729 |
| UBE3C | ubiquitin protein ligase E3C | -0.0239262 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0238749 |
| ZNF217 | zinc finger protein 217 | -0.0237725 |
| RPL6 | ribosomal protein L6 | -0.0235414 |
| TNS3 | tensin 3 | -0.0234317 |
| JMJD1C | jumonji domain containing 1C | -0.0233599 |
