| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FAM13A | family with sequence similarity 13, member A | 0.0947795 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0644772 |
| PLEC | plectin | 0.0579578 |
| LMO7 | LIM domain 7 | 0.0564368 |
| TMEM165 | transmembrane protein 165 | 0.0550411 |
| CES1 | carboxylesterase 1 | 0.0536064 |
| NGLY1 | N-glycanase 1 | 0.0525465 |
| LAMC2 | laminin, gamma 2 | 0.0513354 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0506832 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0491559 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0484524 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.047446 |
| OGA | O-GlcNAcase | 0.0469321 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0461658 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0452278 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0431067 |
| LAMB3 | laminin, beta 3 | 0.0424524 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0416011 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0413515 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0403364 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0400929 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0396738 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0396125 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.039367 |
| SMAD3 | SMAD family member 3 | 0.0385543 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0384898 |
| KCMF1 | potassium channel modulatory factor 1 | 0.037997 |
| RNF145 | ring finger protein 145 | 0.0378658 |
| ARRDC3 | arrestin domain containing 3 | 0.0367488 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.036422 |
| PGK1 | phosphoglycerate kinase 1 | 0.0361134 |
| RAB27B | RAB27B, member RAS oncogene family | 0.035329 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0349613 |
| DSPP | dentin sialophosphoprotein | 0.0345939 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0341413 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0340425 |
| MKI67 | marker of proliferation Ki-67 | 0.0335493 |
| PDE8A | phosphodiesterase 8A | 0.0333723 |
| HDLBP | high density lipoprotein binding protein | 0.0333064 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0332642 |
| NDE1 | nudE neurodevelopment protein 1 | 0.032819 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0326285 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0326168 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0324702 |
| ATP13A3 | ATPase type 13A3 | 0.0319844 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.03188 |
| SLMAP | sarcolemma associated protein | 0.0318662 |
| WDR45B | WD repeat domain 45B | 0.0315294 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0312841 |
| KLC1 | kinesin light chain 1 | 0.0312367 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0311119 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0309704 |
| H1-0 | H1.0 linker histone | 0.0307049 |
| TPD52 | tumor protein D52 | 0.0306083 |
| YEATS2 | YEATS domain containing 2 | 0.0302283 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0299935 |
| SPAG9 | sperm associated antigen 9 | 0.029847 |
| UVRAG | UV radiation resistance associated | 0.0297378 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.029577 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0294153 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0292474 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0292356 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0289117 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0286525 |
| TOP1 | topoisomerase (DNA) I | 0.0284005 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0283809 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0279007 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0278733 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0278511 |
| PAPOLA | poly(A) polymerase alpha | 0.0276532 |
| SUCO | SUN domain containing ossification factor | 0.0276107 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0275768 |
| NCKAP1 | NCK-associated protein 1 | 0.0273566 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0271483 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0270699 |
| JAK1 | Janus kinase 1 | 0.026835 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0266914 |
| HELZ | helicase with zinc finger | 0.0265803 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0261753 |
| PTMA | prothymosin, alpha | 0.0260784 |
| ADAR | adenosine deaminase, RNA-specific | 0.0260445 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0259723 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0258147 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0258039 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0256502 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0256353 |
| CTTN | cortactin | 0.0251296 |
| CUL3 | cullin 3 | 0.024861 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0247855 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0245249 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0244227 |
| KRT18 | keratin 18, type I | 0.0239737 |
| ECT2 | epithelial cell transforming 2 | 0.0237727 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0236433 |
| SDC4 | syndecan 4 | 0.0235704 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | 0.0234404 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0232825 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0228662 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0224997 |
| HYOU1 | hypoxia up-regulated 1 | 0.0224848 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.40468 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.207158 |
| MT2A | metallothionein 2A | -0.159096 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.113459 |
| EGFR | epidermal growth factor receptor | -0.112478 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.108184 |
| ASPH | aspartate beta-hydroxylase | -0.0945658 |
| INTS6 | integrator complex subunit 6 | -0.0849431 |
| RPLP1 | ribosomal protein, large, P1 | -0.0782037 |
| FTL | ferritin, light polypeptide | -0.0607356 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0580642 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0513401 |
| NABP1 | nucleic acid binding protein 1 | -0.0509555 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0492907 |
| EGR1 | early growth response 1 | -0.0486825 |
| EFNA5 | ephrin-A5 | -0.0467437 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0461443 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.045402 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0452476 |
| GRAMD1B | GRAM domain containing 1B | -0.0448705 |
| RPL35A | ribosomal protein L35a | -0.0440157 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0424964 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0414851 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0411578 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0394326 |
| TMSB10 | thymosin beta 10 | -0.0384891 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0382724 |
| SMYD3 | SET and MYND domain containing 3 | -0.0379577 |
| RAD51B | RAD51 paralog B | -0.037524 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0367678 |
| MYOF | myoferlin | -0.036716 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0363616 |
| RPLP0 | ribosomal protein, large, P0 | -0.0360323 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0357904 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0351433 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.034082 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0339644 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0337148 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0334507 |
| RPS8 | ribosomal protein S8 | -0.0332029 |
| RPS23 | ribosomal protein S23 | -0.033174 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.032988 |
| RPL34 | ribosomal protein L34 | -0.0328765 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0319289 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0317507 |
| SUMF1 | sulfatase modifying factor 1 | -0.0311139 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0309878 |
| NDRG1 | N-myc downstream regulated 1 | -0.0302034 |
| RPS25 | ribosomal protein S25 | -0.0299173 |
| MT1X | metallothionein 1X | -0.0296974 |
| HOMER1 | homer scaffolding protein 1 | -0.0296186 |
| RPS6 | ribosomal protein S6 | -0.0287757 |
| GPHN | gephyrin | -0.0285633 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0279653 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.027582 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0274475 |
| RPL31 | ribosomal protein L31 | -0.0269498 |
| MYO1E | myosin IE | -0.0269067 |
| RPS27A | ribosomal protein S27a | -0.0266759 |
| GPC6 | glypican 6 | -0.0256001 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0255883 |
| FOXP1 | forkhead box P1 | -0.0253976 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0253377 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0251546 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0249579 |
| VCL | vinculin | -0.0246632 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0246346 |
| VMP1 | vacuole membrane protein 1 | -0.0243635 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0243257 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0242703 |
| IER3 | immediate early response 3 | -0.0239572 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0239253 |
| RPS24 | ribosomal protein S24 | -0.0239147 |
| RPL23 | ribosomal protein L23 | -0.0237062 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.023618 |
| ENO1 | enolase 1, (alpha) | -0.0235761 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0230532 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0230328 |
| SCEL | sciellin | -0.0230293 |
| RPLP2 | ribosomal protein, large, P2 | -0.0225376 |
| RPS19 | ribosomal protein S19 | -0.0220472 |
| EHBP1 | EH domain binding protein 1 | -0.021949 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0218771 |
| RPS27 | ribosomal protein S27 | -0.0216128 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0215905 |
| AREG | amphiregulin | -0.0215729 |
| RPL8 | ribosomal protein L8 | -0.0214915 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | -0.0213629 |
| RPL30 | ribosomal protein L30 | -0.0213372 |
| UBC | ubiquitin C | -0.0213214 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.021295 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0212705 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0212697 |
| JMJD1C | jumonji domain containing 1C | -0.0205728 |
| RPL11 | ribosomal protein L11 | -0.0205226 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0201567 |
| RPS29 | ribosomal protein S29 | -0.0201476 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0201372 |
| STC1 | stanniocalcin 1 | -0.0201009 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0200786 |
