| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.16618 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.165796 |
| FAM13A | family with sequence similarity 13, member A | 0.137337 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.083699 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0770852 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0769259 |
| SMAD3 | SMAD family member 3 | 0.0747237 |
| NGLY1 | N-glycanase 1 | 0.059279 |
| STC1 | stanniocalcin 1 | 0.0585267 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0581663 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0573642 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0555933 |
| TMSB4X | thymosin beta 4, X-linked | 0.0546089 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0542379 |
| ETV6 | ets variant 6 | 0.053183 |
| FN1 | fibronectin 1 | 0.05254 |
| VEGFA | vascular endothelial growth factor A | 0.0522525 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0507594 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0506146 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0502437 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0499464 |
| ADM | adrenomedullin | 0.0493854 |
| LRRC8C | leucine rich repeat containing 8 family, member C | 0.0492185 |
| ADD3 | adducin 3 (gamma) | 0.0477809 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0474375 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0463312 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0455466 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.043341 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0405753 |
| CDCP1 | CUB domain containing protein 1 | 0.0404188 |
| FAM20C | family with sequence similarity 20, member C | 0.0397804 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0392108 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0391174 |
| FMNL2 | formin-like 2 | 0.0381886 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0381504 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0380698 |
| MTSS1 | metastasis suppressor 1 | 0.0379661 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0377651 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0376456 |
| MX2 | MX dynamin-like GTPase 2 | 0.0374566 |
| LOXL2 | lysyl oxidase-like 2 | 0.0373072 |
| B2M | beta-2-microglobulin | 0.0372323 |
| SP100 | SP100 nuclear antigen | 0.0368531 |
| OPTN | optineurin | 0.0364946 |
| TPR | translocated promoter region, nuclear basket protein | 0.0361861 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0361443 |
| SLFN5 | schlafen family member 5 | 0.036106 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.036098 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0358585 |
| CTNNBL1 | catenin, beta like 1 | 0.0356267 |
| MX1 | MX dynamin-like GTPase 1 | 0.0355674 |
| RUNX2 | runt-related transcription factor 2 | 0.0355513 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0355342 |
| PFKP | phosphofructokinase, platelet | 0.0353444 |
| MECOM | MDS1 and EVI1 complex locus | 0.035099 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0349409 |
| KCTD16 | potassium channel tetramerization domain containing 16 | 0.0349188 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0348435 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0343911 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0343817 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0341029 |
| ADAR | adenosine deaminase, RNA-specific | 0.0339004 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0336543 |
| RIOK3 | RIO kinase 3 | 0.0332449 |
| MEF2A | myocyte enhancer factor 2A | 0.0332223 |
| CEP250 | centrosomal protein 250kDa | 0.0331172 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0330644 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0325151 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0323787 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0323685 |
| DNER | delta/notch-like EGF repeat containing | 0.0322914 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0322747 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0314365 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0313032 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0308692 |
| ATP13A3 | ATPase type 13A3 | 0.0306264 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.030535 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.030531 |
| CA12 | carbonic anhydrase XII | 0.0304926 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0304021 |
| PHF21A | PHD finger protein 21A | 0.0303414 |
| HLA-B | major histocompatibility complex, class I, B | 0.0302683 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.030078 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0300265 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0300104 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0298655 |
| PRELID2 | PRELI domain containing 2 | 0.0298102 |
| FBXO32 | F-box protein 32 | 0.0296867 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0295847 |
| RAI1 | retinoic acid induced 1 | 0.0294839 |
| IFI44L | interferon-induced protein 44-like | 0.0291187 |
| YEATS2 | YEATS domain containing 2 | 0.0289578 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0288568 |
| PID1 | phosphotyrosine interaction domain containing 1 | 0.0287039 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0284523 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0282199 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0279649 |
| TPD52 | tumor protein D52 | 0.0279542 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | 0.0275555 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0274765 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD44 | CD44 molecule (Indian blood group) | -0.187629 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.151827 |
| PCBP2 | poly(rC) binding protein 2 | -0.126948 |
| FNDC3B | fibronectin type III domain containing 3B | -0.116988 |
| VIM | vimentin | -0.10295 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0954259 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0811481 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0771936 |
| GLCCI1 | glucocorticoid induced 1 | -0.0742952 |
| LOX | lysyl oxidase | -0.0736903 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0732232 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0654169 |
| EGR1 | early growth response 1 | -0.064158 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0638576 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.062248 |
| UBC | ubiquitin C | -0.0618971 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0616003 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0614453 |
| NTN4 | netrin 4 | -0.0610279 |
| GPC6 | glypican 6 | -0.0592772 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0570378 |
| FTL | ferritin, light polypeptide | -0.0542268 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0486313 |
| TNNC1 | troponin C type 1 (slow) | -0.0464842 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0447507 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0441733 |
| GRB10 | growth factor receptor-bound protein 10 | -0.042812 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0426879 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0416349 |
| VMP1 | vacuole membrane protein 1 | -0.0412658 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0406531 |
| POTEF | POTE ankyrin domain family, member F | -0.0397546 |
| AADAC | arylacetamide deacetylase | -0.0396525 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0396365 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0394138 |
| USP34 | ubiquitin specific peptidase 34 | -0.0390021 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0388835 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0384274 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0381786 |
| COPA | coatomer protein complex, subunit alpha | -0.0378176 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0363801 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0358838 |
| RPLP1 | ribosomal protein, large, P1 | -0.0356645 |
| KSR1 | kinase suppressor of ras 1 | -0.0355114 |
| TGM2 | transglutaminase 2 | -0.0353505 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0352998 |
| IL1R1 | interleukin 1 receptor, type I | -0.033581 |
| SBF2 | SET binding factor 2 | -0.0330198 |
| KYNU | kynureninase | -0.0328733 |
| DPYD | dihydropyrimidine dehydrogenase | -0.032514 |
| VCL | vinculin | -0.0324545 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.032307 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0314043 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0310261 |
| RPLP0 | ribosomal protein, large, P0 | -0.0306771 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0304643 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.029337 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0284722 |
| RPL23 | ribosomal protein L23 | -0.02844 |
| TUT7 | terminal uridylyl transferase 7 | -0.0282872 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0282815 |
| TOP1 | topoisomerase (DNA) I | -0.0282412 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0281449 |
| YBX1 | Y box binding protein 1 | -0.0278844 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0278637 |
| TMSB10 | thymosin beta 10 | -0.0277924 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0275019 |
| EXOC6B | exocyst complex component 6B | -0.027339 |
| NAV2 | neuron navigator 2 | -0.0265809 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0263176 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0260939 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.025742 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0252593 |
| OSMR | oncostatin M receptor | -0.0252126 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0250867 |
| FBXO11 | F-box protein 11 | -0.0248169 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0247543 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0247233 |
| NDRG1 | N-myc downstream regulated 1 | -0.0246581 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0245578 |
| STK38L | serine/threonine kinase 38 like | -0.0245208 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0243307 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0242879 |
| JUN | jun proto-oncogene | -0.0239654 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0238781 |
| NABP1 | nucleic acid binding protein 1 | -0.0235625 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0233596 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0232291 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0230416 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0226232 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0225096 |
| RPL12 | ribosomal protein L12 | -0.0220855 |
| RHOA | ras homolog family member A | -0.0216408 |
| NF1 | neurofibromin 1 | -0.0216327 |
| HMGA1 | high mobility group AT-hook 1 | -0.0214869 |
| SRP54 | signal recognition particle 54kDa | -0.0212896 |
| SLC38A2 | solute carrier family 38, member 2 | -0.021265 |
| WLS | wntless Wnt ligand secretion mediator | -0.0211947 |
| NRG1 | neuregulin 1 | -0.0211914 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0207396 |
