| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.107215 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0981391 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0967872 |
| PTMA | prothymosin, alpha | 0.0834737 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0643559 |
| FMNL2 | formin-like 2 | 0.0635955 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0632152 |
| TPM3 | tropomyosin 3 | 0.0631471 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0589642 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0564904 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0545859 |
| USP3 | ubiquitin specific peptidase 3 | 0.0543103 |
| MT2A | metallothionein 2A | 0.0531562 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0524989 |
| CALR | calreticulin | 0.0520145 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0518185 |
| FGB | fibrinogen beta chain | 0.0516497 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0490917 |
| APP | amyloid beta (A4) precursor protein | 0.0471506 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0467248 |
| RNF145 | ring finger protein 145 | 0.0454554 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.044955 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0445698 |
| CAVIN1 | caveolae associated protein 1 | 0.0426722 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0423606 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0418571 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0408432 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0393894 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0389792 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0383571 |
| YBX3 | Y box binding protein 3 | 0.03802 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0379319 |
| SMAD3 | SMAD family member 3 | 0.0376392 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0375693 |
| ANXA5 | annexin A5 | 0.0375385 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0374614 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0371825 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0370931 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0363702 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0361556 |
| CCNL1 | cyclin L1 | 0.0355268 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0349828 |
| TPD52 | tumor protein D52 | 0.0345281 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.034023 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0330095 |
| RPS7 | ribosomal protein S7 | 0.032079 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0319707 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0307406 |
| MATR3 | matrin 3 | 0.0304689 |
| FNBP1L | formin binding protein 1-like | 0.0304258 |
| IER3 | immediate early response 3 | 0.0304115 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0300278 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0298707 |
| CASC3 | cancer susceptibility candidate 3 | 0.0295919 |
| ZNF292 | zinc finger protein 292 | 0.029258 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0286549 |
| MSN | moesin | 0.0286105 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0284591 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0282899 |
| JAK1 | Janus kinase 1 | 0.0281423 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0281402 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0279618 |
| FDPS | farnesyl diphosphate synthase | 0.027808 |
| FLNB | filamin B, beta | 0.0276761 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0276582 |
| PYGL | phosphorylase, glycogen, liver | 0.0276433 |
| LMNA | lamin A/C | 0.027624 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0273624 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0273579 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0273182 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0269829 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.026922 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0263773 |
| RPL7A | ribosomal protein L7a | 0.0263624 |
| TFG | TRK-fused gene | 0.0262612 |
| B2M | beta-2-microglobulin | 0.0261262 |
| MTF2 | metal response element binding transcription factor 2 | 0.0258598 |
| CHN1 | chimerin 1 | 0.0258588 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.02563 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0255092 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0254149 |
| SDC4 | syndecan 4 | 0.0253695 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.0253483 |
| RPS12 | ribosomal protein S12 | 0.0253174 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0253018 |
| PRRC1 | proline-rich coiled-coil 1 | 0.0247381 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0247075 |
| CFDP1 | craniofacial development protein 1 | 0.024683 |
| ANXA2 | annexin A2 | 0.0245358 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0241209 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0240899 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0238895 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0236573 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0236558 |
| SERF2 | small EDRK-rich factor 2 | 0.0234934 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0234369 |
| FAM168A | family with sequence similarity 168, member A | 0.0233342 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0232107 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0231484 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0231475 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | -0.202968 |
| TXNRD1 | thioredoxin reductase 1 | -0.190382 |
| GRAMD1B | GRAM domain containing 1B | -0.173982 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.153843 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.140859 |
| TMSB10 | thymosin beta 10 | -0.121239 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.106664 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.09665 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0855662 |
| POTEF | POTE ankyrin domain family, member F | -0.0850396 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0844482 |
| FTL | ferritin, light polypeptide | -0.078019 |
| EGR1 | early growth response 1 | -0.0770217 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0704416 |
| KYNU | kynureninase | -0.0641433 |
| SVIL | supervillin | -0.0626882 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0602331 |
| HDAC9 | histone deacetylase 9 | -0.0599995 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0519391 |
| CMIP | c-Maf inducing protein | -0.0516805 |
| SLC38A2 | solute carrier family 38, member 2 | -0.051001 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0492403 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0492238 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0480699 |
| OSMR | oncostatin M receptor | -0.0471966 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0468752 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0464642 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0464305 |
| EFNA5 | ephrin-A5 | -0.0435584 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0433914 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0430208 |
| JMJD1C | jumonji domain containing 1C | -0.0425019 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0411389 |
| DST | dystonin | -0.0395766 |
| NRG1 | neuregulin 1 | -0.0392792 |
| IGF2 | insulin-like growth factor 2 | -0.0392293 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0390448 |
| PFN1 | profilin 1 | -0.0379783 |
| BICC1 | BicC family RNA binding protein 1 | -0.0373246 |
| RAB10 | RAB10, member RAS oncogene family | -0.0364856 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0357949 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0355155 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0352462 |
| NTN4 | netrin 4 | -0.0348415 |
| RPLP1 | ribosomal protein, large, P1 | -0.0348347 |
| PDE10A | phosphodiesterase 10A | -0.0341601 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0337234 |
| GLIS3 | GLIS family zinc finger 3 | -0.0334933 |
| CENPF | centromere protein F, 350/400kDa | -0.0332132 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0327126 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0325292 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0318713 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.031801 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0316522 |
| AK1 | adenylate kinase 1 | -0.0310814 |
| RPS19 | ribosomal protein S19 | -0.0303949 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0301977 |
| MAP1B | microtubule-associated protein 1B | -0.0299355 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.029801 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0293964 |
| LDHA | lactate dehydrogenase A | -0.0292209 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0285306 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0284434 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.028333 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0278346 |
| RPL35A | ribosomal protein L35a | -0.027292 |
| INO80 | INO80 complex subunit | -0.0268992 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0256726 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0255557 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0254616 |
| ATF4 | activating transcription factor 4 | -0.0253334 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0251766 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0241842 |
| ZNF804A | zinc finger protein 804A | -0.0241057 |
| TDP2 | tyrosyl-DNA phosphodiesterase 2 | -0.0239568 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0239566 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0239152 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0239039 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0238516 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | -0.0235213 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0234408 |
| MYO9A | myosin IXA | -0.0234397 |
| GPATCH2L | G patch domain containing 2-like | -0.0233525 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0231367 |
| RASAL2 | RAS protein activator like 2 | -0.023093 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.022512 |
| NABP1 | nucleic acid binding protein 1 | -0.0222952 |
| RSPO3 | R-spondin 3 | -0.0221852 |
| TCF12 | transcription factor 12 | -0.0221819 |
| BRD2 | bromodomain containing 2 | -0.0220479 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0219577 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0215831 |
| PTK2 | protein tyrosine kinase 2 | -0.0215694 |
| PPP4R3B | protein phosphatase 4 regulatory subunit 3B | -0.021557 |
| VIM | vimentin | -0.0214954 |
| CDK12 | cyclin-dependent kinase 12 | -0.0214403 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.0213818 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0212674 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0211774 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0211173 |
