Topotecan (hydrochloride)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Topotecan (hydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Topotecan (hydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.15707
FAM13A family with sequence similarity 13, member A 0.119888
ERRFI1 ERBB receptor feedback inhibitor 1 0.10001
ELL2 elongation factor, RNA polymerase II, 2 0.0941625
FNDC3A fibronectin type III domain containing 3A 0.0893596
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0769022
SMAD3 SMAD family member 3 0.0740032
HDLBP high density lipoprotein binding protein 0.0696261
GRB10 growth factor receptor-bound protein 10 0.0654886
TSC22D2 TSC22 domain family, member 2 0.062723
FNBP1 formin binding protein 1 0.0610318
ARRDC3 arrestin domain containing 3 0.0598356
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0592729
ACBD3 acyl-CoA binding domain containing 3 0.0589434
ZFAND3 zinc finger, AN1-type domain 3 0.0564273
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0549566
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0529336
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0527666
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0526922
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0523866
PRRC2C proline-rich coiled-coil 2C 0.0523703
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0516343
TFG TRK-fused gene 0.0515195
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0513942
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0513696
KDM6A lysine (K)-specific demethylase 6A 0.0511152
HOOK2 hook microtubule-tethering protein 2 0.0500911
NALF1 NALCN channel auxiliary factor 1 0.0490482
IFIH1 interferon induced with helicase C domain 1 0.04873
CD46 CD46 molecule, complement regulatory protein 0.0482654
SSBP2 single-stranded DNA binding protein 2 0.0473116
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0471048
SEC24D SEC24 family member D 0.0467668
RYBP RING1 and YY1 binding protein 0.0464929
DDIT4 DNA-damage-inducible transcript 4 0.0464556
RBM39 RNA binding motif protein 39 0.0462651
HILPDA hypoxia inducible lipid droplet-associated 0.0461731
PRELID2 PRELI domain containing 2 0.0458564
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0455389
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0454788
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0454186
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0453854
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.0451439
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0451145
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0441395
COL6A3 collagen, type VI, alpha 3 0.0441191
PSD3 pleckstrin and Sec7 domain containing 3 0.043881
SLTM SAFB-like, transcription modulator 0.043696
NPTN neuroplastin 0.0432841
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0432279
HIPK2 homeodomain interacting protein kinase 2 0.0428727
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0427689
TXNIP thioredoxin interacting protein 0.0425682
BLTP1 bridge-like lipid transfer protein family member 1 0.0425323
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0420144
CXCL8 chemokine (C-X-C motif) ligand 8 0.0415081
HELZ helicase with zinc finger 0.0414529
COPA coatomer protein complex, subunit alpha 0.0412315
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0407579
MEF2A myocyte enhancer factor 2A 0.0407162
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0406955
DSTN destrin (actin depolymerizing factor) 0.0404803
PTBP2 polypyrimidine tract binding protein 2 0.040142
PDE8A phosphodiesterase 8A 0.0397082
CCNL1 cyclin L1 0.0394984
COLEC11 collectin sub-family member 11 0.0391619
RSAD2 radical S-adenosyl methionine domain containing 2 0.0386115
ANKHD1 ankyrin repeat and KH domain containing 1 0.0377078
CEP350 centrosomal protein 350kDa 0.037562
SOS1 son of sevenless homolog 1 (Drosophila) 0.0373493
WTAP Wilms tumor 1 associated protein 0.037242
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0370421
RPL5 ribosomal protein L5 0.0367196
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0365027
NFE2L2 nuclear factor, erythroid 2-like 2 0.0361772
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0361606
BPTF bromodomain PHD finger transcription factor 0.0359881
RSRC2 arginine/serine-rich coiled-coil 2 0.0359333
NEK7 NIMA-related kinase 7 0.0352041
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0351176
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0350013
SLMAP sarcolemma associated protein 0.0348875
FOXN3 forkhead box N3 0.0346116
BCLAF1 BCL2-associated transcription factor 1 0.0345901
KMT2E lysine (K)-specific methyltransferase 2E 0.0345482
CTNND1 catenin (cadherin-associated protein), delta 1 0.0344308
TMEM59 transmembrane protein 59 0.03436
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0342548
MBD5 methyl-CpG binding domain protein 5 0.034009
SETD5 SET domain containing 5 0.0337833
CUL3 cullin 3 0.0336657
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0336502
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0335709
LIMCH1 LIM and calponin homology domains 1 0.0335097
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0334479
JARID2 jumonji, AT rich interactive domain 2 0.0334322
XRN1 5'-3' exoribonuclease 1 0.0333903
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0332843
HMGA2 high mobility group AT-hook 2 0.0332621
NAMPT nicotinamide phosphoribosyltransferase 0.0331984

decreased expression

Symbol Name Standardized Value
ENO1 enolase 1, (alpha) -0.132586
TXNRD1 thioredoxin reductase 1 -0.123038
VIM vimentin -0.1053
AK1 adenylate kinase 1 -0.101032
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0919098
MYO1E myosin IE -0.0900636
PTMA prothymosin, alpha -0.0892717
KYNU kynureninase -0.0856085
MT2A metallothionein 2A -0.0814855
FNDC3B fibronectin type III domain containing 3B -0.0765482
FTL ferritin, light polypeptide -0.0757688
LAMB3 laminin, beta 3 -0.074283
PRKCA protein kinase C, alpha -0.0739394
ANXA2 annexin A2 -0.0709555
NAP1L1 nucleosome assembly protein 1-like 1 -0.0688062
JMJD1C jumonji domain containing 1C -0.0676525
TPT1 tumor protein, translationally-controlled 1 -0.0656542
TMSB10 thymosin beta 10 -0.0652397
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0622069
EXT1 exostosin glycosyltransferase 1 -0.0613365
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0608432
GLS2 glutaminase 2 (liver, mitochondrial) -0.0604045
PARD3 par-3 family cell polarity regulator -0.0600288
SH3D19 SH3 domain containing 19 -0.0595073
LSAMP limbic system-associated membrane protein -0.0573383
SRP54 signal recognition particle 54kDa -0.0551277
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0551145
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0549374
TM4SF1 transmembrane 4 L six family member 1 -0.0548927
CALU calumenin -0.0540482
RPS6 ribosomal protein S6 -0.054032
S100A10 S100 calcium binding protein A10 -0.0537436
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0527618
MORF4L2 mortality factor 4 like 2 -0.0527076
ADNP activity-dependent neuroprotector homeobox -0.0525388
KDM4C lysine (K)-specific demethylase 4C -0.0518385
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0518153
LAMC2 laminin, gamma 2 -0.0517529
SMYD3 SET and MYND domain containing 3 -0.0517378
RPL11 ribosomal protein L11 -0.0515692
SQSTM1 sequestosome 1 -0.0507529
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0498626
RPS21 ribosomal protein S21 -0.0491083
RPL19 ribosomal protein L19 -0.0471856
MAP4 microtubule-associated protein 4 -0.0470225
ARHGAP12 Rho GTPase activating protein 12 -0.0467082
ZBTB20 zinc finger and BTB domain containing 20 -0.0455748
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0455662
RPS3 ribosomal protein S3 -0.0451452
RIGI RNA sensor RIG-I -0.0448815
MTDH metadherin -0.0439769
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0433601
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0428189
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0426361
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0422311
FOXP1 forkhead box P1 -0.0421742
IARS1 isoleucyl-tRNA synthetase 1 -0.0414351
TTC17 tetratricopeptide repeat domain 17 -0.0412966
WDR7 WD repeat domain 7 -0.041227
LDHA lactate dehydrogenase A -0.0410909
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0410179
TPM4 tropomyosin 4 -0.0408719
TPI1 triosephosphate isomerase 1 -0.0405803
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0402525
RAB10 RAB10, member RAS oncogene family -0.0400042
MPZL1 myelin protein zero-like 1 -0.0398869
TJP1 tight junction protein 1 -0.0394614
DOCK4 dedicator of cytokinesis 4 -0.0391203
AKAP9 A kinase (PRKA) anchor protein 9 -0.0391029
EZR ezrin -0.0386271
EEF2 eukaryotic translation elongation factor 2 -0.0386117
NME7 NME/NM23 family member 7 -0.0385126
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0376728
CSNK1E casein kinase 1, epsilon -0.0375444
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -0.0369827
ARHGAP21 Rho GTPase activating protein 21 -0.0368635
POTEF POTE ankyrin domain family, member F -0.0367416
CANX calnexin -0.036608
INHBA inhibin, beta A -0.0364646
TBC1D22A TBC1 domain family, member 22A -0.0364285
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0363928
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.036068
EHBP1 EH domain binding protein 1 -0.0359456
GLG1 golgi glycoprotein 1 -0.0358643
PKM pyruvate kinase, muscle -0.0358594
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0358137
BRWD1 bromodomain and WD repeat domain containing 1 -0.0356924
RPS11 ribosomal protein S11 -0.0355757
JUN jun proto-oncogene -0.0355707
MAML3 mastermind-like 3 (Drosophila) -0.0353156
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0353068
PATJ PATJ crumbs cell polarity complex component -0.0352874
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0352792
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0351447
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0347918
BZW2 basic leucine zipper and W2 domains 2 -0.0347577
APP amyloid beta (A4) precursor protein -0.0346484
SETX senataxin -0.0345929
UBC ubiquitin C -0.0345718
MYO9A myosin IXA -0.0344054