| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | 0.087474 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0755759 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0531405 |
| RPS3 | ribosomal protein S3 | 0.0481861 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0462966 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.044079 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0428761 |
| RPL37A | ribosomal protein L37a | 0.0428443 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0401968 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0386983 |
| RPL26 | ribosomal protein L26 | 0.0385959 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0367088 |
| TPM3 | tropomyosin 3 | 0.0362296 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.036176 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0358486 |
| RPS2 | ribosomal protein S2 | 0.0354068 |
| MCL1 | myeloid cell leukemia 1 | 0.0353702 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0349388 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0327033 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0324478 |
| OGA | O-GlcNAcase | 0.0316491 |
| COPA | coatomer protein complex, subunit alpha | 0.0312426 |
| XPOT | exportin, tRNA | 0.0311107 |
| PLEC | plectin | 0.0308172 |
| MKI67 | marker of proliferation Ki-67 | 0.0303805 |
| CTTN | cortactin | 0.0301964 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0299684 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0297601 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0297282 |
| KRT18 | keratin 18, type I | 0.0295297 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0292529 |
| CEP192 | centrosomal protein 192kDa | 0.0280113 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0278346 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.027567 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0267484 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0261443 |
| CEP250 | centrosomal protein 250kDa | 0.0259182 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0258135 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0253565 |
| RRM2 | ribonucleotide reductase M2 | 0.0249279 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0244343 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0243507 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0240975 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0240343 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0239773 |
| RPL3 | ribosomal protein L3 | 0.0233456 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.0225537 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0225029 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0224669 |
| SRPK1 | SRSF protein kinase 1 | 0.0221474 |
| RYK | receptor-like tyrosine kinase | 0.0221076 |
| ADAR | adenosine deaminase, RNA-specific | 0.0217896 |
| SET | SET nuclear proto-oncogene | 0.0217079 |
| CLTC | clathrin, heavy chain (Hc) | 0.0216984 |
| SMAD3 | SMAD family member 3 | 0.0215646 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0214439 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0208678 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0208356 |
| RPL7A | ribosomal protein L7a | 0.020705 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0206714 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.020671 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0205778 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0205156 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0204089 |
| LARS1 | leucyl-tRNA synthetase 1 | 0.0203022 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0201977 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0201917 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0199929 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 0.0199274 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0197743 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0197088 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0196368 |
| MORF4L2 | mortality factor 4 like 2 | 0.0196284 |
| GOLGA3 | golgin A3 | 0.0195291 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0192984 |
| MAD1L1 | MAD1 mitotic arrest deficient-like 1 (yeast) | 0.0192056 |
| RPN1 | ribophorin I | 0.0191631 |
| TMEM165 | transmembrane protein 165 | 0.0191194 |
| TLN1 | talin 1 | 0.0191053 |
| RPS18 | ribosomal protein S18 | 0.0187305 |
| COPG1 | coatomer protein complex, subunit gamma 1 | 0.0184171 |
| RBM28 | RNA binding motif protein 28 | 0.018279 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0182697 |
| GOSR2 | golgi SNAP receptor complex member 2 | 0.0182274 |
| PMM2 | phosphomannomutase 2 | 0.0182269 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0181297 |
| MDC1 | mediator of DNA-damage checkpoint 1 | 0.017754 |
| HDGF | hepatoma-derived growth factor | 0.0177455 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.017708 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0176985 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0174718 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0173942 |
| WRN | Werner syndrome, RecQ helicase-like | 0.0171258 |
| NCKAP1 | NCK-associated protein 1 | 0.0169557 |
| SETD5 | SET domain containing 5 | 0.0169419 |
| HYOU1 | hypoxia up-regulated 1 | 0.0169043 |
| NSD2 | nuclear receptor binding SET domain protein 2 | 0.0167932 |
| RPS12 | ribosomal protein S12 | 0.0167907 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0167184 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0166776 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TFPI2 | tissue factor pathway inhibitor 2 | -0.168509 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.15813 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.14604 |
| TMSB10 | thymosin beta 10 | -0.145976 |
| TXNRD1 | thioredoxin reductase 1 | -0.117433 |
| GRAMD1B | GRAM domain containing 1B | -0.108403 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0929171 |
| YBX3 | Y box binding protein 3 | -0.085243 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0755174 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.07316 |
| OSMR | oncostatin M receptor | -0.0706018 |
| UBC | ubiquitin C | -0.0695742 |
| EGR1 | early growth response 1 | -0.0671826 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.062226 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0594564 |
| VIM | vimentin | -0.0586589 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0572868 |
| ENO1 | enolase 1, (alpha) | -0.0561178 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0559426 |
| TPI1 | triosephosphate isomerase 1 | -0.0555667 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0553044 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0541285 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0536328 |
| VMP1 | vacuole membrane protein 1 | -0.0515194 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0500777 |
| STC1 | stanniocalcin 1 | -0.0499246 |
| RPLP1 | ribosomal protein, large, P1 | -0.0489558 |
| PFN1 | profilin 1 | -0.0487029 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0487025 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0475023 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0461854 |
| POTEF | POTE ankyrin domain family, member F | -0.0442668 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0436213 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0429263 |
| CDK17 | cyclin-dependent kinase 17 | -0.0415198 |
| PDE10A | phosphodiesterase 10A | -0.0404483 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0387629 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0386667 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0381978 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0377277 |
| JMJD1C | jumonji domain containing 1C | -0.037625 |
| NF1 | neurofibromin 1 | -0.0372641 |
| RPLP0 | ribosomal protein, large, P0 | -0.0361459 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0349892 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0346977 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0343963 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0332385 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0326339 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0322124 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0310865 |
| RASAL2 | RAS protein activator like 2 | -0.031028 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0310123 |
| SEPTIN7 | septin 7 | -0.0308194 |
| DST | dystonin | -0.0305189 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0303825 |
| LATS2 | large tumor suppressor kinase 2 | -0.0298569 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0298361 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0297831 |
| S100A6 | S100 calcium binding protein A6 | -0.0296626 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0295475 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0294471 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0294429 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0292615 |
| NLGN1 | neuroligin 1 | -0.0291542 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0289819 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0282915 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.028205 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0280213 |
| CALD1 | caldesmon 1 | -0.0275204 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.027418 |
| RPL12 | ribosomal protein L12 | -0.0273879 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0273057 |
| RPL8 | ribosomal protein L8 | -0.0265774 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0264423 |
| CBX3 | chromobox homolog 3 | -0.0262707 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.025948 |
| RPL34 | ribosomal protein L34 | -0.0259167 |
| VCL | vinculin | -0.0255533 |
| RPS27 | ribosomal protein S27 | -0.0252176 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0252173 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0247648 |
| RPL23 | ribosomal protein L23 | -0.0243661 |
| MATR3 | matrin 3 | -0.024196 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0241216 |
| PTMS | parathymosin | -0.0237034 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0236678 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.0236546 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0233835 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0232832 |
| SSH2 | slingshot protein phosphatase 2 | -0.0232164 |
| BPTF | bromodomain PHD finger transcription factor | -0.0232065 |
| TAGLN2 | transgelin 2 | -0.0230983 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0230962 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0229944 |
| H1-0 | H1.0 linker histone | -0.0229167 |
| RTN4 | reticulon 4 | -0.0227609 |
| PHF14 | PHD finger protein 14 | -0.0223982 |
| B2M | beta-2-microglobulin | -0.0222512 |
| SVIL | supervillin | -0.0221968 |
| EGFR | epidermal growth factor receptor | -0.0220568 |
