| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.342719 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.081353 |
| CCNL1 | cyclin L1 | 0.0783704 |
| TMSB4X | thymosin beta 4, X-linked | 0.077611 |
| VEGFA | vascular endothelial growth factor A | 0.0675463 |
| CALR | calreticulin | 0.0655484 |
| NDRG1 | N-myc downstream regulated 1 | 0.0564468 |
| PTMA | prothymosin, alpha | 0.0563123 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0530856 |
| PLAU | plasminogen activator, urokinase | 0.0527881 |
| FAM13A | family with sequence similarity 13, member A | 0.0525644 |
| PLEC | plectin | 0.0480639 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0465818 |
| RNF145 | ring finger protein 145 | 0.0448429 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0446574 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0426566 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0423788 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0417307 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0416492 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0413237 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0400708 |
| ADAR | adenosine deaminase, RNA-specific | 0.0399133 |
| HLA-B | major histocompatibility complex, class I, B | 0.0393745 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0375632 |
| RBM25 | RNA binding motif protein 25 | 0.0359589 |
| G0S2 | G0/G1 switch 2 | 0.035309 |
| RBM39 | RNA binding motif protein 39 | 0.0351645 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0345318 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.034195 |
| AHDC1 | AT hook, DNA binding motif, containing 1 | 0.0329869 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0322303 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0322035 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0321003 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0320297 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0314874 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0312334 |
| TPR | translocated promoter region, nuclear basket protein | 0.0302875 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0300706 |
| YBX3 | Y box binding protein 3 | 0.0295624 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0295211 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0293259 |
| LAMB3 | laminin, beta 3 | 0.0291313 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0291204 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.029077 |
| PAPOLA | poly(A) polymerase alpha | 0.0278665 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0277314 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.027524 |
| COPA | coatomer protein complex, subunit alpha | 0.0263738 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0263074 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0262751 |
| MXD1 | MAX dimerization protein 1 | 0.0261876 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.025987 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0259491 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0256665 |
| GPX4 | glutathione peroxidase 4 | 0.0254935 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0254569 |
| RPL37A | ribosomal protein L37a | 0.0251831 |
| B2M | beta-2-microglobulin | 0.0246796 |
| SLMAP | sarcolemma associated protein | 0.024665 |
| UPP1 | uridine phosphorylase 1 | 0.0246253 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0244996 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0243599 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0242252 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0241768 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0238488 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0236252 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0236186 |
| NUP58 | nucleoporin 58 | 0.0234843 |
| HLA-A | major histocompatibility complex, class I, A | 0.0234065 |
| CCNY | cyclin Y | 0.0233621 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0233337 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0231762 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0230274 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0228258 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0227215 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.0227118 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0226759 |
| PNN | pinin, desmosome associated protein | 0.0225004 |
| MSN | moesin | 0.0223826 |
| SETD5 | SET domain containing 5 | 0.0221188 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0221129 |
| YTHDC1 | YTH domain containing 1 | 0.0220471 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0220457 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0217062 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.021604 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0213903 |
| SPAG5 | sperm associated antigen 5 | 0.0212675 |
| CLINT1 | clathrin interactor 1 | 0.0212568 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0211554 |
| RBM5 | RNA binding motif protein 5 | 0.0210743 |
| HDGF | hepatoma-derived growth factor | 0.020882 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0203692 |
| TPM3 | tropomyosin 3 | 0.0203433 |
| TFG | TRK-fused gene | 0.0201511 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0198174 |
| ADM | adrenomedullin | 0.0197392 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0196162 |
| MKRN1 | makorin ring finger protein 1 | 0.0196125 |
| RPN1 | ribophorin I | 0.0194885 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | 0.0191408 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.28114 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.208648 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.20807 |
| UBC | ubiquitin C | -0.15392 |
| POTEF | POTE ankyrin domain family, member F | -0.131695 |
| S100A6 | S100 calcium binding protein A6 | -0.117748 |
| TMSB10 | thymosin beta 10 | -0.090935 |
| ENO1 | enolase 1, (alpha) | -0.0890979 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0729418 |
| AHNAK | AHNAK nucleoprotein | -0.0683498 |
| RPLP1 | ribosomal protein, large, P1 | -0.0634001 |
| FTL | ferritin, light polypeptide | -0.0629199 |
| ASPH | aspartate beta-hydroxylase | -0.0616602 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0586369 |
| RPLP0 | ribosomal protein, large, P0 | -0.0562521 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0546811 |
| RPL34 | ribosomal protein L34 | -0.0534967 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0532788 |
| KRT7 | keratin 7, type II | -0.0523682 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0523443 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0518265 |
| LMO7 | LIM domain 7 | -0.0506198 |
| RPS27A | ribosomal protein S27a | -0.049858 |
| ANXA2 | annexin A2 | -0.0489494 |
| CANX | calnexin | -0.0482726 |
| VIM | vimentin | -0.0481804 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0475717 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0475457 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0470885 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0438364 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0433453 |
| ERBIN | erbb2 interacting protein | -0.0420938 |
| RACK1 | receptor for activated C kinase 1 | -0.0391877 |
| MAP4 | microtubule-associated protein 4 | -0.0391631 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0391526 |
| EFNA5 | ephrin-A5 | -0.0390806 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0389542 |
| S100A10 | S100 calcium binding protein A10 | -0.0382708 |
| HMGA1 | high mobility group AT-hook 1 | -0.0375333 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0367994 |
| VCL | vinculin | -0.0366429 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0364331 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0361763 |
| CD2AP | CD2-associated protein | -0.0359256 |
| CCND1 | cyclin D1 | -0.0355619 |
| MYO1E | myosin IE | -0.0350257 |
| RPL35A | ribosomal protein L35a | -0.034945 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.034208 |
| EGFR | epidermal growth factor receptor | -0.0338236 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.032081 |
| DTNA | dystrobrevin, alpha | -0.0317754 |
| RHOA | ras homolog family member A | -0.031661 |
| MAP1B | microtubule-associated protein 1B | -0.0313198 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0301602 |
| RPL8 | ribosomal protein L8 | -0.0294175 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0292455 |
| ATXN1 | ataxin 1 | -0.027977 |
| CD44 | CD44 molecule (Indian blood group) | -0.027895 |
| FHIT | fragile histidine triad | -0.0277983 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0276849 |
| RPL27A | ribosomal protein L27a | -0.0274703 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0268416 |
| LDHA | lactate dehydrogenase A | -0.0266907 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0265109 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0262141 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0261972 |
| KRT19 | keratin 19, type I | -0.0260907 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0259828 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0258898 |
| TPM4 | tropomyosin 4 | -0.025836 |
| RPS24 | ribosomal protein S24 | -0.0255349 |
| GOLGB1 | golgin B1 | -0.0254154 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0253908 |
| SVIL | supervillin | -0.0253646 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0252855 |
| FBXO32 | F-box protein 32 | -0.0252774 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0252061 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0250627 |
| RASAL2 | RAS protein activator like 2 | -0.0249912 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0247614 |
| SQSTM1 | sequestosome 1 | -0.0244744 |
| NF1 | neurofibromin 1 | -0.0241712 |
| TXNRD1 | thioredoxin reductase 1 | -0.0241644 |
| VGLL3 | vestigial-like family member 3 | -0.0240857 |
| RPL30 | ribosomal protein L30 | -0.0238779 |
| RPL23 | ribosomal protein L23 | -0.0237324 |
| TJP1 | tight junction protein 1 | -0.0231165 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0229798 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0229492 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0227833 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.022614 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0225563 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0225089 |
| VMP1 | vacuole membrane protein 1 | -0.0221995 |
| RPL14 | ribosomal protein L14 | -0.0220135 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.0217926 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0215211 |
| HDLBP | high density lipoprotein binding protein | -0.0211945 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0211648 |
| EPCAM | epithelial cell adhesion molecule | -0.0209297 |
