| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Topotecan (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Topotecan (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.110636 |
| MCL1 | myeloid cell leukemia 1 | 0.0907287 |
| FN1 | fibronectin 1 | 0.0770954 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0633496 |
| PRELID2 | PRELI domain containing 2 | 0.0535156 |
| SPAG9 | sperm associated antigen 9 | 0.0504895 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0497658 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0489209 |
| FAM13A | family with sequence similarity 13, member A | 0.0482112 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0460578 |
| OGA | O-GlcNAcase | 0.045175 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0437791 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0426579 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.042241 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0395374 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0389925 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0375755 |
| FLNB | filamin B, beta | 0.0374825 |
| HELZ | helicase with zinc finger | 0.0374482 |
| TPM3 | tropomyosin 3 | 0.0371399 |
| CTBP2 | C-terminal binding protein 2 | 0.0370095 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0347804 |
| FMNL2 | formin-like 2 | 0.0346208 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0345671 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0336336 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0328917 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0328659 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0310907 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0309676 |
| NUP58 | nucleoporin 58 | 0.0307153 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.0307057 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0301499 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0301296 |
| EZR | ezrin | 0.0293245 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0293243 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.028463 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0284507 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0280591 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0278007 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0277431 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0274146 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0271521 |
| FLNA | filamin A, alpha | 0.0270905 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0268597 |
| RPL3 | ribosomal protein L3 | 0.0268335 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.0268093 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.026765 |
| NGLY1 | N-glycanase 1 | 0.0265598 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0261283 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0259716 |
| ANXA5 | annexin A5 | 0.0258373 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.02567 |
| NBAS | neuroblastoma amplified sequence | 0.0255766 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0255313 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0250695 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0250019 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0249608 |
| DENND1A | DENN/MADD domain containing 1A | 0.0245993 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0245786 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0242274 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0241883 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0241342 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0240183 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0236669 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0232649 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0228554 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0228379 |
| FNIP1 | folliculin interacting protein 1 | 0.0226963 |
| SUCO | SUN domain containing ossification factor | 0.0225688 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0225166 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0225 |
| ANXA1 | annexin A1 | 0.022342 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.02173 |
| CDC73 | cell division cycle 73 | 0.0215186 |
| AUTS2 | autism susceptibility candidate 2 | 0.0214745 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0214061 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.0213575 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0212365 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0211969 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0210646 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0209346 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0206849 |
| NCKAP1 | NCK-associated protein 1 | 0.0206099 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0204906 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0200459 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0197778 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0197466 |
| NCAM1 | neural cell adhesion molecule 1 | 0.0197305 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0195614 |
| TMSB4X | thymosin beta 4, X-linked | 0.0191875 |
| APP | amyloid beta (A4) precursor protein | 0.0191237 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0190753 |
| COPA | coatomer protein complex, subunit alpha | 0.018964 |
| ATP13A3 | ATPase type 13A3 | 0.0189079 |
| DNER | delta/notch-like EGF repeat containing | 0.0187508 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0187156 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0186593 |
| MYO10 | myosin X | 0.0185343 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0184863 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0181128 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.205389 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.179383 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.116017 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.115125 |
| TMSB10 | thymosin beta 10 | -0.109842 |
| GDA | guanine deaminase | -0.106515 |
| VIM | vimentin | -0.100828 |
| FTL | ferritin, light polypeptide | -0.0982444 |
| SMYD3 | SET and MYND domain containing 3 | -0.0969048 |
| TXNRD1 | thioredoxin reductase 1 | -0.0847947 |
| RPLP1 | ribosomal protein, large, P1 | -0.0831453 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0825483 |
| COL5A2 | collagen, type V, alpha 2 | -0.0785947 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0781237 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.071912 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0701674 |
| RPS6 | ribosomal protein S6 | -0.0665348 |
| RPL35A | ribosomal protein L35a | -0.0649175 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.064905 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0641464 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.062883 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0625472 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0559541 |
| MT2A | metallothionein 2A | -0.0557201 |
| PDE10A | phosphodiesterase 10A | -0.0535375 |
| RPL31 | ribosomal protein L31 | -0.0528297 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0526537 |
| S100A6 | S100 calcium binding protein A6 | -0.0524446 |
| RPS23 | ribosomal protein S23 | -0.0508673 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0488894 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0474053 |
| RPLP0 | ribosomal protein, large, P0 | -0.0467256 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0446823 |
| RPS24 | ribosomal protein S24 | -0.0436329 |
| RPS19 | ribosomal protein S19 | -0.0410908 |
| EFNA5 | ephrin-A5 | -0.0397001 |
| RPL34 | ribosomal protein L34 | -0.0390716 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0386198 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0385011 |
| ANTXR1 | anthrax toxin receptor 1 | -0.038439 |
| RPLP2 | ribosomal protein, large, P2 | -0.0383911 |
| PALLD | palladin, cytoskeletal associated protein | -0.0381623 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0376026 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0370543 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0368571 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0368339 |
| RPS8 | ribosomal protein S8 | -0.0362122 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0349534 |
| PDE7B | phosphodiesterase 7B | -0.0346615 |
| RPL12 | ribosomal protein L12 | -0.0340263 |
| RPS29 | ribosomal protein S29 | -0.0338681 |
| RTN1 | reticulon 1 | -0.0337451 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0337235 |
| RPS13 | ribosomal protein S13 | -0.0333806 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0329796 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0328974 |
| RPS14 | ribosomal protein S14 | -0.0324496 |
| RPS21 | ribosomal protein S21 | -0.0317326 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0317081 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.031677 |
| VDAC1 | voltage-dependent anion channel 1 | -0.03156 |
| PTGR1 | prostaglandin reductase 1 | -0.0309921 |
| RPL36A | ribosomal protein L36a | -0.0308342 |
| ENO1 | enolase 1, (alpha) | -0.0308088 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0307947 |
| RPL23 | ribosomal protein L23 | -0.0307727 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0306071 |
| RPS27 | ribosomal protein S27 | -0.030576 |
| DST | dystonin | -0.030458 |
| SRGN | serglycin | -0.0304382 |
| ASPH | aspartate beta-hydroxylase | -0.0302991 |
| RPL36 | ribosomal protein L36 | -0.0302723 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0299572 |
| BPTF | bromodomain PHD finger transcription factor | -0.0296984 |
| RPS27A | ribosomal protein S27a | -0.0296742 |
| S100A10 | S100 calcium binding protein A10 | -0.0296552 |
| JMJD1C | jumonji domain containing 1C | -0.0296472 |
| PFN1 | profilin 1 | -0.0295473 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.029527 |
| NRCAM | neuronal cell adhesion molecule | -0.0287636 |
| KIAA0825 | KIAA0825 | -0.0283364 |
| RPS25 | ribosomal protein S25 | -0.0279318 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0277244 |
| VCL | vinculin | -0.0276912 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0273699 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0273029 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0271756 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0271223 |
| EGR1 | early growth response 1 | -0.0271197 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0267328 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0266898 |
| RPL19 | ribosomal protein L19 | -0.0261114 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.025111 |
| RPL11 | ribosomal protein L11 | -0.0249979 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0249061 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0247928 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0246367 |
| RPS12 | ribosomal protein S12 | -0.0245476 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0241733 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0241639 |
